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J-GLOBAL ID：202002253434117535   整理番号：20A1205758

複製ストレスは損傷染色体のATR/Chk1依存性非ランダム分離を誘導する【JST・京大機械翻訳】

Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes

著者 (17件)： Xing Meichun (Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China) ,  Zhang Fengjiao (Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China) ,  Liao Hongwei (Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China) ,  Chen Sisi (Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China) ,  Che Luanqing (Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China) ,  Wang Xiaohui (Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China) ,  Bao Zhengqiang (Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China) ,  Ji Fang (Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China) ,  Chen Gaoying (Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China) ,  Zhang Huihui (Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China) ,  Li Wen (Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China) ,  Chen Zhihua (Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China) ,  Liu Ying (Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark) ,  Hickson Ian D. (Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark) ,  Shen Huahao (Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China) ,  Shen Huahao (State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong 510120, China) ,  Ying Songmin (Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital, Zhejiang University School of Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, Hangzhou 310009, China)
資料名： Molecular Cell  (Molecular Cell)
巻： 78  号： 4  ページ： 714-724.e5  発行年： 2020年 
JST資料番号： W1167A  ISSN： 1097-2765  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 非ランダムDNA分離(NDS)は,最も古いDNA鎖を持つ姉妹染色分体が,2つの娘細胞のうちの1つだけによって排他的に継承される有糸分裂イベントである。この現象は様々な生物にわたって観察されているが,このイベントのメカニズムと生理的関連性はほとんど定義されていない。ここでは,DNA複製ストレスがヒト細胞でNDSを誘導できることを示した。古い鋳型DNAのこの偏った遺伝は非対称DNA損傷応答(DDR)と関連し,テロメアDNAから少なくとも部分的に誘導される。機構的には,ATR/CHK1シグナル伝達経路がNDS仲介において必須の役割を果たすことを明らかにした。このバイアスされた分離過程は,新たに複製されたDNAを継承する損傷娘細胞において細胞周期停止と細胞死をもたらすことを示した。したがって,これらのデータは癌細胞集団内のゲノム完全性の維持におけるNDSの重要な役割を同定し,癌細胞の活性化による複製ストレスを受けている。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： DNA【核酸】 ,  *染色体 ,  腫瘍細胞 ,  ヒト ,  有糸分裂 ,  非対称性 ,  ゲノム ,  DNA複製 ,  細胞死 ,  *チェックポイントキナーゼ1 ,  細胞周期停止 ,  *複製ストレス ,  テロメアDNA ,  娘細胞 ,  DNA損傷応答

著者キーワード (5件)： 非ランダムDNA分離 ,  複製ストレス ,  偏った継承 ,  非対称DNA損傷応答 ,  ATR/Chk1

分類 (3件)： 細胞分裂・増殖  (EF02020D) ,  遺伝子の複製  (EC02030F) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (7件)： 複製ストレス ,  損傷 ,  染色体 ,  ATR ,  Chk1 ,  依存性 ,  誘導