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J-GLOBAL ID：202002256129962901   整理番号：20A2660272

IL-27駆動転写ネットワークはTヘルパー細胞サブセットを通してIL-10発現の調節因子を同定する【JST・京大機械翻訳】

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

著者 (39件)： Zhang Huiyuan (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Madi Asaf (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Madi Asaf (Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel) ,  Yosef Nir (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Yosef Nir (Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California, Berkeley, CA, USA) ,  Chihara Norio (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Chihara Norio (Division of Neurology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Awasthi Amit (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Awasthi Amit (Center for Human Microbial Ecology, Translational Health Science and Technology Institute(an autonomous institute of the Department of Biotechnology, Government of India), NCR Biotech Science Cluster, Faridabad, India) ,  Pot Caroline (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Pot Caroline (Laboratories of Neuroimmunology, Division of Neurology and Neuroscience Research Center, Department of Clinical Neurosciences, Lausanne University Hospital, Lausanne, Switzerland) ,  Lambden Conner (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Lambden Conner (Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Srivastava Amitabh (Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA) ,  Burkett Patrick R. (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Burkett Patrick R. (Biogen, 300 Binney St., Cambridge, MA, USA) ,  Nyman Jackson (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Nyman Jackson (Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Christian Elena (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Christian Elena (Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Etminan Yasaman (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Lee Annika (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Stroh Helene (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Xia Junrong (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Karwacz Katarzyna (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Karwacz Katarzyna (Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, USA) ,  Thakore Pratiksha I. (Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Acharya Nandini (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Schnell Alexandra (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Wang Chao (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Apetoh Lionel (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Apetoh Lionel (INSERM, U1231, Dijon, France) ,  Rozenblatt-Rosen Orit (Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Anderson Ana C. (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Regev Aviv (Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Regev Aviv (Howard Hughes Medical Institute, Department of Biology, Koch Institute and Ludwig Center, Massachusetts Institute of Technology, Cambridge, MA, USA) ,  Regev Aviv (Genentech, 1 DNA Way, South San Francisco, CA, USA) ,  Kuchroo Vijay K. (Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA) ,  Kuchroo Vijay K. (Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA)
資料名： Cell Reports  (Cell Reports)
巻： 33  号： 8  ページ： Null  発行年： 2020年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： インターロイキン-27(IL-27)はIL-10の誘導を含む複数の機構を介して炎症を抑制する免疫調節性サイトカインであるが,その多様な機能を仲介する転写ネットワークは不明である。一時的RNAプロファイリングと計算アルゴリズムを組み合わせて,T細胞においてIL-27により誘導された79の転写因子を予測した。Il10に対する実験的に洗練された調節ネットワークを生成する,11の既知および5つの陽性(Cebpb,Fosl2,Tbx21,Hlx,およびAtf3)および2つの陰性(Irf9およびIrf8)Il10調節因子を検証した。1型調節性T細胞においてIL-27により誘導されるシグネチャ遺伝子の発現を協調的に駆動し,全てのTヘルパー細胞でIL-10発現を仲介する,2種類の中心レギュレーター,Prdm1とMafを報告し,結腸Foxp3+調節T細胞の調節表現型を決定した。Prdm1/Maf二重ノックアウトマウスは自然大腸炎を発症し,ll10欠損マウスを表現型する。本研究は,IL-27駆動転写ネットワークへの洞察を提供し,Tヘルパー細胞サブセットを横断する免疫調節プログラムを調整する2つの共有Il10調節因子を同定した。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： RNA【核酸】 ,  遺伝子 ,  結腸 ,  表現型 ,  T細胞 ,  大腸炎 ,  インターロイキン ,  *ヘルパーT細胞 ,  転写因子 ,  *インターロイキン10 ,  ノックアウトマウス
準シソーラス用語： *インターロイキン27 ,  *調節因子 ,  FoxP3 ,  Maf群転写因子 , 【Automatic Indexing@JST】

著者キーワード (9件)： IL-27 ,  転写ネットワーク ,  Tr1 ,  IL-10 ,  Tヘルパー細胞 ,  大腸炎 ,  Treg ,  Prdm1 ,  Maf

分類 (4件)： 免疫反応一般  (ED03010T) ,  細胞生理一般  (EF02010S) ,  免疫性疾患・アレルギー性疾患一般  (GD04010C) ,  サイトカイン  (EB08090G)

タイトルに関連する用語 (8件)： IL-27 ,  転写ネットワーク ,  Tヘルパー細胞 ,  サブセット ,  IL-10 ,  発現 ,  調節因子 ,  同定