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J-GLOBAL ID：202002256694879415   整理番号：20A1272029

訓練された免疫の定義と健康と疾患におけるその役割【JST・京大機械翻訳】

Defining trained immunity and its role in health and disease

著者 (36件)： Netea Mihai G. (Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands) ,  Netea Mihai G. (Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands) ,  Netea Mihai G. (Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany) ,  Dominguez-Andres Jorge (Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands) ,  Dominguez-Andres Jorge (Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands) ,  Barreiro Luis B. (Department of Genetics, CHU Sainte-Justine Research Centre, Montreal, QC, Canada) ,  Barreiro Luis B. (Department of Pediatrics, University of Montreal, Montreal, QC, Canada) ,  Barreiro Luis B. (Genetics Section, Department of Medicine, The University of Chicago, Chicago, IL, USA) ,  Chavakis Triantafyllos (Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Dresden, Germany) ,  Chavakis Triantafyllos (Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK) ,  Divangahi Maziar (Meakins-Christie Laboratories, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada) ,  Divangahi Maziar (Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada) ,  Divangahi Maziar (McGill International TB Centre, McGill University Health Centre, Montreal, QC, Canada) ,  Fuchs Elaine (Howard Hughes Medical Institute, Robin Chemers Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA) ,  Joosten Leo A. B. (Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands) ,  Joosten Leo A. B. (Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands) ,  van der Meer Jos W. M. (Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands) ,  van der Meer Jos W. M. (Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands) ,  Mhlanga Musa M. (Division of Chemical and Systems Biology, Department of Integrative Biomedical Sciences, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa) ,  Mhlanga Musa M. (Gene Expression and Biophysics Unit, Instituto de Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, Lisbon, Portugal) ,  Mulder Willem J. M. (Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA) ,  Mulder Willem J. M. (Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA) ,  Mulder Willem J. M. (Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, Netherlands) ,  Riksen Niels P. (Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands) ,  Riksen Niels P. (Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands) ,  Schlitzer Andreas (Myeloid Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany) ,  Schultze Joachim L. (Department of Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany) ,  Stabell Benn Christine (Bandim Health Project, OPEN, Department of Clinical Research, University of Southern Denmark, Odense, Denmark) ,  Sun Joseph C. (Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Sun Joseph C. (Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Sun Joseph C. (Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY, USA) ,  Xavier Ramnik J. (Broad Institute of MIT and Harvard, Cambridge, MA, USA) ,  Xavier Ramnik J. (Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ,  Latz Eicke (Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany) ,  Latz Eicke (Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA) ,  Latz Eicke (German Center for Neurodegenerative Diseases, Bonn, Germany)
資料名： Nature Reviews. Immunology  (Nature Reviews. Immunology)
巻： 20  号： 6  ページ： 375-388  発行年： 2020年 
JST資料番号： W1371A  ISSN： 1474-1733  資料種別： 逐次刊行物 (A)
記事区分： 文献レビュー  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 免疫記憶は獲得免疫系の定義特性であるが,自然免疫系の活性化はその後のトリガーに対する反応性の増強をもたらす。このプロセスは,「訓練された免疫」と呼ばれている。過去10年間の研究は,宿主防御に対する訓練された免疫の広い利点を指摘しているが,免疫仲介および慢性炎症性疾患における潜在的に有害な結果を示唆している。ここでは,生物学的過程として「訓練された免疫」を定義し,自然刺激および訓練された免疫の誘導を形成する後成的および代謝的再プログラミングイベントについて議論する。ここでは,この分野におけるリーダーのグループは,自然免疫システムにおいて起こる記憶型応答を参照する「訓練された免疫」の現在の理解を定義する。著者らは,訓練された免疫に関与する重要な後成的および代謝過程の現在の理解を議論し,免疫媒介疾患および癌におけるその関連性を考察する。Copyright Springer Nature Limited 2020 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *自然免疫 ,  免疫記憶 ,  適応免疫
準シソーラス用語： 獲得免疫 ,  炎症性疾患 , 【Automatic Indexing@JST】

分類 (1件)： 免疫反応一般  (ED03010T)

タイトルに関連する用語 (5件)： 訓練 ,  免疫 ,  定義 ,  疾患 ,  役割