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J-GLOBAL ID：202002256719672554   整理番号：20A1062268

局所的に進行した肝内胆管癌に対するALPPS 積極的手術は腫瘍学的利益につながるか? 国際多施設研究【JST・京大機械翻訳】

ALPPS for Locally Advanced Intrahepatic Cholangiocarcinoma: Did Aggressive Surgery Lead to the Oncological Benefit? An International Multi-center Study

著者 (59件)： Li Jun (Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Moustafa Mohamed (Hepatobiliary Surgery and Liver Transplant Unit, University of Padua, Padua, Italy) ,  Linecker Michael (Swiss HPB and Transplantation Center, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland) ,  Lurje Georg (Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany) ,  Capobianco Ivan (Department of General, Visceral and Transplantation Surgery, University Hospital Tuebingen, Tuebingen, Germany) ,  Baumgart Janine (Department of General, Visceral and Transplantation Surgery, University Hospital Mainz, Mainz, Germany) ,  Ratti Francesca (Hepatobiliary Surgery Division, San Raffaele Hospital, Milan, Italy) ,  Rauchfuss Falk (Department of General, Visceral and Vascular Surgery, University Hospital Jena, Jena, Germany) ,  Balci Deniz (Department of Surgery, Ankara University, Ankara, Turkey) ,  Fernandes Eduardo (Department of Surgery, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil) ,  Fernandes Eduardo (Department of Surgery and Transplantation, Sao Lucas Hospital - Copacabana, Rio de Janeiro, Brazil) ,  Montalti Roberto (Department of Public Health, Federico II University Hospital, Naples, Italy) ,  Robles-Campos Ricardo (Department of Surgery, Virgen de la Arrixaca Hospital, IMIB-Arrixaca, Murcia, Spain) ,  Bjornsson Bergthor (Department of Surgery and Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden) ,  Topp Stefan A. (Department of General, Visceral and Pediatric Surgery, University Hospital Duesseldorf, Duesseldorf, Germany) ,  Fronek Jiri (Department of Transplant Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic) ,  Fronek Jiri (Department of Anatomy, Second Faculty of Medicine, Charles University, Prague, Czech Republic) ,  Liu Chao (Department of Hepato-Pancreato-Biliary Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China) ,  Wahba Roger (Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany) ,  Bruns Christiane (Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany) ,  Brunner Stefan M. (Department of Surgery, University Medical Center Regensburg, Regensburg, Germany) ,  Schlitt Hans J. (Department of Surgery, University Medical Center Regensburg, Regensburg, Germany) ,  Heumann Asmus (Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Stueben Bjorn-Ole (Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Izbicki Jakob R. (Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Bednarsch Jan (Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany) ,  Gringeri Enrico (Hepatobiliary Surgery and Liver Transplant Unit, University of Padua, Padua, Italy) ,  Fasolo Elisa (Hepatobiliary Surgery and Liver Transplant Unit, University of Padua, Padua, Italy) ,  Rolinger Jens (Department of General, Visceral and Transplantation Surgery, University Hospital Tuebingen, Tuebingen, Germany) ,  Kristek Jakub (Department of Transplant Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic) ,  Kristek Jakub (Department of Anatomy, Second Faculty of Medicine, Charles University, Prague, Czech Republic) ,  Hernandez-Alejandro Roberto (Division of Transplantation and Hepatobiliary Surgery, University of Rochester, Rochester, NY, USA) ,  Schnitzbauer Andreas (Department of General, Visceral and Transplantation Surgery, University Hospital Frankfurt, Frankfurt, Germany) ,  Nuessler Natascha (Department of General, Visceral and endocrine Surgery, Muenchen Klinik Neuperlach, Munich, Germany) ,  Schon Michael R. (Klinikum Karlsruhe, Karlsruhe, Germany) ,  Voskanyan Sergey (Center for Surgery and Transplantology, A.I. Burnazyan Russian State Scientific Center FMBC of FMBA, Moscow, Russia) ,  Petrou Athanasios S. (Department of General Surgery, Nicosia Teaching Hospital, Strovolos, Cyprus) ,  Hahn Oszkar (1st Department of Surgery, Semmelweis University, Budapest, Hungary) ,  Soejima Yuji (Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan) ,  Vicente Emilio (“Clara Campal” Oncological Center, Sanchinarro University Hospital, San Pablo University. CEU, Madrid, Spain) ,  Castro-Benitez Carlos (Centre Hepato-Biliaire, AP-HP Hopital Paul Brousse, Inserm U 935, Univ Paris-Saclay, Villejuif, France) ,  Adam Rene (Centre Hepato-Biliaire, AP-HP Hopital Paul Brousse, Inserm U 935, Univ Paris-Saclay, Villejuif, France) ,  Tomassini Federico (Department of Human Structure and Repair, Faculty of Medicine, Ghent University, Ghent, Belgium) ,  Troisi Roberto Ivan (Department of Human Structure and Repair, Faculty of Medicine, Ghent University, Ghent, Belgium) ,  Troisi Roberto Ivan (Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy) ,  Kantas Alexandros (Department of Surgery, Division of HPB Surgery, Asklepios Hospital Barmbek, Semmelweis University Budapest, Campus Hamburg, Hamburg, Germany) ,  Oldhafer Karl Juergen (Department of Surgery, Division of HPB Surgery, Asklepios Hospital Barmbek, Semmelweis University Budapest, Campus Hamburg, Hamburg, Germany) ,  Ardiles Victoria (HPB Surgery and Liver Transplant Unit, Italian Hospital Buenos Aires, Buenos Aires, Argentina) ,  de Santibanes Eduardo (HPB Surgery and Liver Transplant Unit, Italian Hospital Buenos Aires, Buenos Aires, Argentina) ,  Malago Massimo (Department of Surgery, University College London, London, UK) ,  Clavien Pierre-Alain (Swiss HPB and Transplantation Center, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland) ,  Vivarelli Marco (Hepatobiliary and Abdominal Transplantation Surgery, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy) ,  Settmacher Utz (Department of General, Visceral and Vascular Surgery, University Hospital Jena, Jena, Germany) ,  Aldrighetti Luca (Hepatobiliary Surgery Division, San Raffaele Hospital, Milan, Italy) ,  Neumann Ulf (Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany) ,  Petrowsky Henrik (Swiss HPB and Transplantation Center, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland) ,  Cillo Umberto (Hepatobiliary Surgery and Liver Transplant Unit, University of Padua, Padua, Italy) ,  Lang Hauke (Department of General, Visceral and Transplantation Surgery, University Hospital Mainz, Mainz, Germany) ,  Nadalin Silvio (Department of General, Visceral and Transplantation Surgery, University Hospital Tuebingen, Tuebingen, Germany)
資料名： Annals of Surgical Oncology  (Annals of Surgical Oncology)
巻： 27  号： 5  ページ： 1372-1384  発行年： 2020年 
JST資料番号： W1826A  ISSN： 1068-9265  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 【背景】ALPPSは,進行期に原発性および二次性肝悪性腫瘍の切除可能性を増加させることがわかる。本研究の目的は,肝内胆管癌(ICC)に対するALPPSの外科的および腫瘍学的転帰を検証することであった。【方法】研究コホートは,2009年8月から2018年1月の間の31の国際センターからの患者によるALPPS登録に基づいた。化学療法のみを受けている傾向スコア適合患者を,生存分析のための対照としてSEERデータベースから選択した。【結果】ALPPSを受けている100人の患者が募集され,99人が第2段階を完了し,11日の中間期の期間を中央値とした。速度論的成長速度の中央値は23ml/日であった。R0切除は87(85%)で達成された。最初に,罹患率と死亡率の高い比率は,過去2年間において,29%の重篤な合併症比率と7%の90日の罹患率に着実に減少した。肝切除後の肝不全は90日死亡率の主な原因であった。多変量解析は,重症合併症に対する唯一の危険因子であるステージ2手術(FLR2)における不十分な将来の肝臓遺残を明らかにした(OR2.91,p=0.02)。傾向スコア整合分析は,緩和化学療法と比較してALPPS群において優れた全体生存を示した(中央値全生存:26.4か月対14か月,1,2,および3年生存率:それぞれ,82.4%,70.5%および39.6%対51.2%,21.4%および11.3%)。しかし,生存利益は,不十分なFLR2または多焦点ICCを有する患者に対するサブグループ分析において確認されなかった。結論:ALPPSは,局所的に進行したICCにおいてR0切除を達成する際に高い有効性を示した。この積極的な手術から最も腫瘍学的利益を得るために,ALPPSは単一病変と十分なFLR2を有する患者に限定される。Copyright The Author(s) 2020 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 多変量解析 ,  データベース ,  死亡率 ,  速度論 ,  薬物療法 ,  緩和現象 ,  肝切除 ,  母集団 ,  有効性 ,  成長速度 ,  *合併症 ,  危険因子
準シソーラス用語： 肝不全 ,  悪性腫瘍 ,  *肝内胆管癌 , 【Automatic Indexing@JST】

分類 (1件)： 消化器の腫よう  (GH04000D)

タイトルに関連する用語 (6件)： 肝内胆管癌 ,  手術 ,  腫瘍学 ,  利益 ,  施設 ,  研究