文献

J-GLOBAL ID：202002257414604319   整理番号：20A2572324

CNS傍神経節腫の分子特性評価は,異なる腫瘍疾患としての馬尾傍神経節腫を同定する【JST・京大機械翻訳】

Molecular characterization of CNS paragangliomas identifies cauda equina paragangliomas as a distinct tumor entity

著者 (51件)： Schweizer Leonille (Department of Neuropathology, Berlin Institute of Health, Charite-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet Zu Berlin, Berlin, Germany) ,  Schweizer Leonille (German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Thierfelder Felix (Department of Neuropathology, Berlin Institute of Health, Charite-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet Zu Berlin, Berlin, Germany) ,  Thierfelder Felix (German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Thomas Christian (Institute of Neuropathology, University Hospital Muenster, Muenster, Germany) ,  Soschinski Patrick (Institute of Neuropathology, University Hospital Muenster, Muenster, Germany) ,  Suwala Abigail (Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany) ,  Suwala Abigail (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany) ,  Stichel Damian (Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany) ,  Stichel Damian (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany) ,  Wefers Annika K. (Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany) ,  Wefers Annika K. (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany) ,  Wefers Annika K. (Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany) ,  Wessels Lars (Department of Neurosurgery, Charite-Universitaetsmedizin Berlin, Berlin, Germany) ,  Misch Martin (Department of Neurosurgery, Charite-Universitaetsmedizin Berlin, Berlin, Germany) ,  Kim Hee-yeong (Department of Neuropathology, Berlin Institute of Health, Charite-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet Zu Berlin, Berlin, Germany) ,  Kim Hee-yeong (German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Jodicke Ruben (Department of Neuropathology, Berlin Institute of Health, Charite-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet Zu Berlin, Berlin, Germany) ,  Teichmann Daniel (Department of Neuropathology, Berlin Institute of Health, Charite-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet Zu Berlin, Berlin, Germany) ,  Kaul David (Department of Radiation Oncology and Radiotherapy, Charite Universitaetsmedizin Berlin, Berlin, Germany) ,  Kahn Johannes (Department of Radiology, Charite Universitaetsmedizin Berlin, Berlin, Germany) ,  Bockmayr Michael (Department of Pathology, Berlin Institute of Health, Charite-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet Zu Berlin, Berlin, Germany) ,  Bockmayr Michael (Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany) ,  Bockmayr Michael (Research Institute Children’s Cancer Center Hamburg, Hamburg, Germany) ,  Hasselblatt Martin (Institute of Neuropathology, University Hospital Muenster, Muenster, Germany) ,  Younsi Alexander (Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany) ,  Unterberg Andreas (Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany) ,  Knie Bettina (Department of Neurosurgery, Vivantes Klinikum Im Friedrichshain, Berlin, Germany) ,  Walter Jan (Department of Neurosurgery, Universitaetsklinikum Jena, Jena, Germany) ,  Al Safatli Diaa (Department of Neurosurgery, Universitaetsklinikum Jena, Jena, Germany) ,  May Sven-Axel (Department of Neurosurgery, Klinikum Chemnitz, Chemnitz, Germany) ,  Jodicke Andreas (Department of Neurosurgery, Vivantes Klinikum Neukolln, Berlin, Germany) ,  Ntoulias Georgios (Department of Neurosurgery, Vivantes Klinikum Neukolln, Berlin, Germany) ,  Moskopp Dag (Department of Neurosurgery, Vivantes Klinikum Im Friedrichshain, Berlin, Germany) ,  Vajkoczy Peter (Department of Neurosurgery, Charite-Universitaetsmedizin Berlin, Berlin, Germany) ,  Heppner Frank L. (Department of Neuropathology, Berlin Institute of Health, Charite-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet Zu Berlin, Berlin, Germany) ,  Heppner Frank L. (German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Heppner Frank L. (Cluster of Excellence, NeuroCure, Berlin, Germany) ,  Heppner Frank L. (German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany) ,  Capper David (Department of Neuropathology, Berlin Institute of Health, Charite-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet Zu Berlin, Berlin, Germany) ,  Capper David (German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Hartmann Wolfgang (Division of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital Muenster, Muenster, Germany) ,  Hartmann Christian (Department of Neuropathology, Institute of Pathology, Hannover Medical School, Hannover, Germany) ,  von Deimling Andreas (Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany) ,  von Deimling Andreas (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany) ,  Reuss David E. (Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany) ,  Reuss David E. (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany) ,  Scholer Anne (Department of Neuropathology, Berlin Institute of Health, Charite-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet Zu Berlin, Berlin, Germany) ,  Scholer Anne (German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany) ,  Koch Arend (Department of Neuropathology, Berlin Institute of Health, Charite-Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet Zu Berlin, Berlin, Germany) ,  Koch Arend (German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany)
資料名： Acta Neuropathologica  (Acta Neuropathologica)
巻： 140  号： 6  ページ： 893-906  発行年： 2020年 
JST資料番号： A0895B  ISSN： 0001-6322  CODEN： ANPTA  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 傍神経節腫/褐色細胞腫は,体全体を通して副腎または神経節から生じる稀な神経内分泌腫瘍である。それらは,運転者変化の著しい多様性を示し,症例の40%まで生殖系列変異と関連する。abdomino-胸郭傍神経節腫の包括的な分子プロファイリングは,4つの分子定義および臨床的に関連するサブタイプを明らかにした。cauda equina領域のパラガングリオーマは,定義された分子サブタイプの1つに属すると考えられているが,系統的な分子解析はまだ行われていない。本研究では,57cauda equina paragangliomaのゲノムワイドDNAメチル化プロファイルを分析し,これらの腫瘍が非脊髄傍神経節腫および他の腫瘍と後成的に異なることを示した。他の部位の傍神経節腫とは対照的に,染色体不均衡はcauda equina paragangliomasで広く欠如している。さらに,RNAとDNAエキソーム配列決定は,非脊髄傍神経節腫で発見された高頻度の遺伝的変化が,cauda equina paragangliomasで欠如していることを明らかにした。組織学的に,cauda equina paragangliomasは,汎サイトケラチンおよびサイトケラチン18に対し,しばしば神経節細胞分化および強い免疫反応性を示し,これは他の部位の傍神経節腫では一般的ではない。家族性傍神経節腫症候群はなかった。腫瘍は稀に再発し(9%),脊髄コンパートメント内で多発性病変を呈したが(7%),CNS外では転移しなかった。要約すれば,cauda equina paragangliomasは独特の臨床および形態分子プロファイルにより定義される異なる散発性腫瘍実体を示す。Copyright The Author(s) 2020 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： DNA【核酸】 ,  RNA【核酸】 ,  遺伝 ,  染色体 ,  *腫瘍 ,  *神経節 ,  脊髄 ,  副腎 ,  分化 ,  免疫反応 ,  褐色細胞腫 ,  *パラガングリオーマ ,  サイトケラチン
準シソーラス用語： DNAメチル化 ,  エクソーム , 【Automatic Indexing@JST】

著者キーワード (6件)： 傍神経節腫 ,  馬尾 ,  頭頚部 ,  SDHB ,  GATA3 ,  DNAメチル化

分類 (2件)： 神経系の腫よう  (GN04000V) ,  臨床腫よう学一般  (GE03010Y)

タイトルに関連する用語 (6件)： 傍神経節腫 ,  分子特性 ,  評価 ,  腫瘍疾患 ,  馬尾 ,  同定