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J-GLOBAL ID：202002261171582816   整理番号：20A1172324

うつ病のゲノムワイドメタ分析は102非依存性変異体を同定し,前頭前野脳領域の重要性を明らかにする【JST・京大機械翻訳】

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

著者 (51件)： Howard David M. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Adams Mark J. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Clarke Toni-Kim (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Hafferty Jonathan D. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Gibson Jude (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Shirali Masoud (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Coleman Jonathan R. I. (Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK) ,  Coleman Jonathan R. I. (NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK) ,  Hagenaars Saskia P. (Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK) ,  Hagenaars Saskia P. (NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK) ,  Ward Joey (Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK) ,  Wigmore Eleanor M. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Alloza Clara (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Shen Xueyi (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Barbu Miruna C. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Xu Eileen Y. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Whalley Heather C. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  Marioni Riccardo E. (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK) ,  Marioni Riccardo E. (Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK) ,  Porteous David J. (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK) ,  Porteous David J. (Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK) ,  Davies Gail (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK) ,  Davies Gail (Department of Psychology, University of Edinburgh, Edinburgh, UK) ,  Deary Ian J. (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK) ,  Deary Ian J. (Department of Psychology, University of Edinburgh, Edinburgh, UK) ,  Hemani Gibran (Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health, Sciences, Bristol Medical School, University of Bristol, Bristol, UK) ,  Berger Klaus (Institute of Epidemiology & Social Medicine, University of Muenster, Muenster, Germany) ,  Teismann Henning (Institute of Epidemiology & Social Medicine, University of Muenster, Muenster, Germany) ,  Rawal Rajesh (Institute of Epidemiology & Social Medicine, University of Muenster, Muenster, Germany) ,  Arolt Volker (Department of Psychiatry, University of Muenster, Muenster, Germany) ,  Baune Bernhard T. (Department of Psychiatry, University of Melbourne, Victoria, Australia) ,  Dannlowski Udo (Department of Psychiatry, University of Muenster, Muenster, Germany) ,  Domschke Katharina (Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany) ,  Tian Chao (23andMe, Inc, Mountain View, CA, USA) ,  Hinds David A. (23andMe, Inc, Mountain View, CA, USA) ,  Trzaskowski Maciej (Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia) ,  Byrne Enda M. (Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia) ,  Ripke Stephan (Department of Psychiatry, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Berlin, Germany) ,  Ripke Stephan (Medical and Population Genetics, Broad Institute, Cambridge, MA, USA) ,  Ripke Stephan (Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA) ,  Smith Daniel J. (Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK) ,  Sullivan Patrick F. (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden) ,  Sullivan Patrick F. (Department of Genetics, University of North Carolina, Chapel Hill, NC, USA) ,  Sullivan Patrick F. (Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA) ,  Wray Naomi R. (Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia) ,  Breen Gerome (Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK) ,  Breen Gerome (NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK) ,  Lewis Cathryn M. (Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK) ,  Lewis Cathryn M. (NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK) ,  McIntosh Andrew M. (Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK) ,  McIntosh Andrew M. (Department of Psychology, University of Edinburgh, Edinburgh, UK)
資料名： Nature Neuroscience  (Nature Neuroscience)
巻： 22  号： 3  ページ： 343-352  発行年： 2019年 
JST資料番号： W1370A  ISSN： 1097-6256  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： Major低下は,典型的に低い気分と貧血に関連する衰弱性精神疾患である。うつ病は,疾患の多原性のために現在のサンプルサイズで解明するのが困難な遺伝的成分を持っている。サンプルサイズを最大化するために,著者らは,欝病の3つの最大のゲノムワイド関連研究から,807,553人の個人(246,363人と561人の対照)に関するデータをメタ分析した。著者らは,シナプス構造と神経伝達に関連する遺伝子と遺伝子経路の両方を含む,102の独立した変異体,269の遺伝子,および15の遺伝子座を同定した。濃縮分析は,前頭前野脳領域の重要性のさらなる証拠を提供した。1,306,354個体(414,055症例と8892,299対照)の独立複製試料において,102関連変異体の87は多重試験補正後に有意であった。これらの知見は,欝病の複雑な遺伝的アーキテクチャの理解を深め,病因を理解し,新しい治療アプローチを開発するためのいくつかの将来の道を提供する。欝病の遺伝的メタ分析を行い,269の関連遺伝子を見出した。これらの遺伝子はいくつかの潜在的な薬物再配置機会を強調し,欝病との関係は神経症と喫煙に対して見出された。Copyright The Author(s), under exclusive licence to Springer Nature America, Inc. 2019 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 神経症 ,  遺伝 ,  遺伝子 ,  シナプス ,  神経伝達 ,  精神病 ,  多重化 ,  *うつ病 ,  計算機アーキテクチャ ,  病因 ,  メタ分析 ,  *前頭前野 ,  *脳領域 ,  *大脳半球

分類 (1件)： 中枢神経系  (EJ12030F)

タイトルに関連する用語 (9件)： うつ病 ,  ゲノム ,  メタ分析 ,  非依存性 ,  変異体 ,  同定 ,  前頭前野 ,  脳領域 ,  重要性