文献

J-GLOBAL ID：202002264969534007   整理番号：20A2762585

非アルコール性脂肪性肝疾患はリポファジー増加と関連した肝液晶の蓄積を経験する【JST・京大機械翻訳】

Nonalcoholic fatty liver disease experiences accumulation of hepatic liquid crystal associated with increasing lipophagy

著者 (34件)： Wang Liyang (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Wang Liyang (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Xu MengMeng (Department of Pediatrics, Columbia University, New York, USA) ,  Jones Odell D. (University of Pennsylvania School of Medicine ULAR, Philadelphia, USA) ,  Li Zhongguang (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Li Zhongguang (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Li Zhongguang (Ohio State University School of Medicine, Columbus, USA) ,  Liang Yu (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Liang Yu (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Yu Qiuxia (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Yu Qiuxia (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Li Jiali (University Hospital Shaanxi Normal University, Xi’an, China) ,  Wu Yajun (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Wu Yajun (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Lei Xinjuan (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Lei Xinjuan (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  He Boling (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  He Boling (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Yue Huimin (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Yue Huimin (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Xiao Liqin (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Xiao Liqin (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Zhou Rong (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Zhou Rong (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Zhang Wei (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Zhang Wei (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Zhou Xin (Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an, China) ,  Zhang Yuhui (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Zhang Yuhui (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China) ,  Bryant Joseph L. (University of Maryland School of Medicine, Baltimore, USA) ,  Ma Jianjie (Ohio State University School of Medicine, Columbus, USA) ,  Liu Yingli (University Hospital Shaanxi Normal University, Xi’an, China) ,  Xu Xuehong (Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Xi’an, China) ,  Xu Xuehong (Laboratory of Cell Biology, Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an, China)
資料名： Cell & Bioscience (Web)  (Cell & Bioscience (Web))
巻： 10  号： 1  ページ： 1-18  発行年： 2020年 
JST資料番号： U7373A  ISSN： 2045-3701  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 過去30年間,非アルコール性脂肪肝疾患(NAFLD)の発生率は30%上昇している。しかし,肝不全を予測する明確な機構や正確な方法はない。ここでは,肝脂質滴(HLD)における液晶質の相転移を,予想予後の新しい方法として明らかにする。NAFLDは高脂肪(HiF)飼料にC57BL/6Jマウスに給餌して誘導した。次に,これらのNAFLD肝臓を偏光顕微鏡,X線回折および小角散乱,脂質成分クロマトグラフィー分析および蛋白質発現分析で評価した。マウスモデルと患者試料からの光学活性HLDは,両方とも液晶特性を有することを確認した。肝臓MAP1LC3A発現を評価し,液晶HLD(LC-HLD)形成におけるオートファジーの役割を決定した。正常食事コホートと異なり,HiF食マウスは,Maltese交差複屈折,相転移,および液晶への流動性シグネチャを示すHLDを含むNAFLD肝臓を発症した。これらのLC-HLDは0°Cで異方性結晶に転移し,結晶性を維持した。温度が42°Cに上昇すると液晶と結晶HLDの両方が等方性液滴形に変換する。これらの等方性HLDは,遅い温度低下と共に,速い温度低下と異方性結晶を有する異方性LCに首尾よく転移した。これらの所見は,患者肝臓で重複した。内部光学活性のない患者LC-HLDを発見し,HLDがLC特性を獲得する機構として脂質飽和にヒントを得た。LC-HLD増加に伴うMAP1LC3Aのダウンレギュレーションは,NAFLD LC-HLD形成におけるオートファジーも関与した。HLD中の両親媒性脂質濃度の増加は,LC-HLDとして存在する親水性と疎水性の交互層への組織化に有利であった。したがって,NAFLD患者のHLDにおける相転移による液体結晶化の程度を評価することは,疾患重症度を明らかにし,肝損傷を迫ることを予測する可能性がある。Copyright 2020 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： X線回折 ,  *液晶 ,  液滴 ,  結晶化 ,  相転移 ,  複屈折 ,  クロマトグラフィー ,  疎水性 ,  脂質 ,  脂肪肝 ,  小角散乱 ,  予後 ,  ダウンレギュレーション ,  オートファジー
準シソーラス用語： *非アルコール性脂肪性肝疾患 , 【Automatic Indexing@JST】

著者キーワード (5件)： 高脂肪性脂肪肝 ,  非アルコール性脂肪性肝疾患(NAFLD) ,  液晶 ,  相転移 ,  生検診断

分類 (2件)： 代謝異常・栄養性疾患一般  (GD05010J) ,  消化器の基礎医学  (GH01020E)

引用文献 (50件)：

• World J Gastroenterol; Liver transplantation for nonalcoholic fatty liver disease: new challenges and new opportunities; M Shaker, A Tabbaa, M Albeldawi, N Alkhouri; 20; 18; 2014; 5320-5330; 10.3748/wjg.v20.i18.5320; citation_id=CR1
• JAMA; Nonalcoholic fatty liver disease: a systematic review; ME Rinella; 313; 22; 2015; 2263-2273; 10.1001/jama.2015.5370; citation_id=CR2
• PLoS One; Gender-differences in the associations between circulating creatine kinase, blood pressure, body mass and non-alcoholic fatty liver disease in asymptomatic asians; CH Yen, KT Wang, PY Lee, CC Liu, YC Hsieh, JY Kuo; 12; 6; 2017; e0179898; 10.1371/journal.pone.0179898; citation_id=CR3
• Fam Pract; Development and validation study of a non-alcoholic fatty liver disease risk scoring model among adults in China; Q Zhang, CKH Wong, K Kung, JCY Chan, BTW Sy, M Lam; 34; 6; 2017; 667-672; 10.1093/fampra/cmx049; citation_id=CR4
• Am J Gastroenterol; Steatohepatitis in obese children: a cause of chronic liver dysfunction; JR Moran, FK Ghishan, SA Halter, HL Greene; 78; 6; 1983; 374-377; citation_id=CR5

タイトルに関連する用語 (5件)： 非アルコール性脂肪性肝疾患 ,  リポファジー ,  液晶 ,  蓄積 ,  経験