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J-GLOBAL ID：202002269812720874   整理番号：20A2250048

静磁場と電場への曝露は2型糖尿病を治療する【JST・京大機械翻訳】

Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes

著者 (39件)： Carter Calvin S. (Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Huang Sunny C. (Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Huang Sunny C. (Medical Scientist Training Program, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA) ,  Searby Charles C. (Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Cassaidy Benjamin (Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Miller Michael J. (Department of Physics and Astronomy, University of Iowa, Iowa City, IA, USA) ,  Grzesik Wojciech J. (Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA) ,  Piorczynski Ted B. (Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT, USA) ,  Pak Thomas K. (Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Pak Thomas K. (Medical Scientist Training Program, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA) ,  Walsh Susan A. (Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Acevedo Michael (Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Zhang Qihong (Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Mapuskar Kranti A. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Milne Ginger L. (Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA) ,  Hinton Antentor O. (Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA) ,  Guo Deng-Fu (Department of Neuroscience and Pharmacology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Weiss Robert (Department of Internal Medicine, Division of Cardiology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Bradberry Kyle (Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA) ,  Taylor Eric B. (Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA) ,  Taylor Eric B. (Department of Molecular Physiology and Biophysics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Rauckhorst Adam J. (Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA) ,  Rauckhorst Adam J. (Department of Molecular Physiology and Biophysics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Dick David W. (Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Akurathi Vamsidhar (Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Falls-Hubert Kelly C. (Medical Scientist Training Program, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA) ,  Falls-Hubert Kelly C. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Wagner Brett A. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Carter Walter A. (Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Wang Kai (College of Public Health, Department of Biostatistics, University of Iowa, Iowa City, IA, USA) ,  Norris Andrew W. (Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Norris Andrew W. (Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA) ,  Rahmouni Kamal (Department of Neuroscience and Pharmacology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Buettner Garry R. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Hansen Jason M. (Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT, USA) ,  Spitz Douglas R. (Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Abel E. Dale (Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA) ,  Abel E. Dale (Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Iowa Hospitals & Clinics, Iowa City, IA, USA) ,  Sheffield Val C. (Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA)
資料名： Cell Metabolism  (Cell Metabolism)
巻： 32  号： 4  ページ： 561-574.e7  発行年： 2020年 
JST資料番号： W3108A  ISSN： 1550-4131  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 異常な酸化還元シグナル伝達は,2型糖尿病(T2D)を含む多くの慢性代謝性疾患の病態生理の基礎となる。全身酸化還元ホメオスタシスを再平衡させるための方法論には,限られた成功があった。非侵襲的で持続的アプローチは,T2Dの治療に対する酸化還元シグナリングの長期制御を可能にする。静的磁性および電場(sBE)は,全身GSH-to-GSSGレドックス対を非侵襲的に調節し,還元するより健康的な全身酸化還元環境を促進することを報告する。驚くべきことに,T2Dのマウスモデルに適用した場合,sBEはインシュリン耐性とグルコース不耐性を3日間で急速に改善し,副作用は観察されなかった。肝臓ミトコンドリアにおけるSOD2による酸素代謝の常磁性副生成物の捕捉は,これらのインスリン感作効果を完全に消失させ,ミトコンドリアスーパーオキシドがこれらの治療変化の誘導を仲介することを示した。著者らの知見は,T2Dの非侵襲的治療および潜在的に他のレドックス関連疾患に対する内因性電磁石受容機構を利用する顕著な酸化還元調節現象を紹介する。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 常磁性 ,  *電場 ,  電磁石 ,  超酸化物 ,  インスリン ,  感作 ,  副作用 ,  ミトコンドリア ,  酸化還元反応 ,  磁性 ,  *静磁場 ,  細胞情報伝達 ,  *2型糖尿病 ,  インスリン抵抗性
準シソーラス用語： 内因性 , 【Automatic Indexing@JST】

著者キーワード (10件)： レドックス ,  2型糖尿病 ,  インスリン抵抗性 ,  電磁場 ,  ROS ,  スーパーオキシド ,  グルタチオン ,  ラジカル対機構 ,  ミトコンドリア ,  肝臓

分類 (1件)： 代謝異常・栄養性疾患一般  (GD05010J)

タイトルに関連する用語 (5件)： 静磁場 ,  電場 ,  曝露 ,  2型糖尿病 ,  治療