文献

J-GLOBAL ID：202002270679406732   整理番号：20A2371863

YAPとNR4A1の間の調節ループは細胞増殖とアポトーシスをバランスさせる【JST・京大機械翻訳】

A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

著者 (20件)： He Lingli (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Yuan Liang (School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China) ,  Yu Wentao (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Sun Yang (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Jiang Dan (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Wang Xiaodong (School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China) ,  Feng Xue (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Wang Zuoyun (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Xu Jinjin (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Yang Ruizeng (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Zhang Wenxiang (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Feng Hua (Omics Core of Bio-Med Big Data Center, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China) ,  Chen Hang-zi (State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian Province, China) ,  Zeng Yi Arial (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Hui Lijian (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Wu Qiao (State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian Province, China) ,  Zhang Yonglong (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Zhang Lei (State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) ,  Zhang Lei (School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China) ,  Zhang Lei (Bio-Research Innovation Center, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Suzhou 215121, China)
資料名： Cell Reports  (Cell Reports)
巻： 33  号： 3  ページ： Null  発行年： 2020年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： Hippoシグナル伝達経路は,細胞増殖とアポトーシスの組織化を介して器官サイズと組織ホメオスタシスを維持する。この経路がどのように細胞アポトーシスを誘発するかは,ほとんど未調査のままである。ここでは,YAPがNR4A1の転写,燐酸化およびミトコンドリア局在性を調節する,Hippo経路のプロアポトーシスおよび抗腫瘍効果を仲介する,Hippo経路の標的としてNR4A1を同定した。次に,NR4A1はYAPのフィードバック阻害剤として機能し,その分解を促進し,それによって肝再生と腫瘍形成時のYAPの機能を阻害する。本研究は,肝再生と腫瘍形成の間のHippoシグナル伝達活性を調整するNR4A1とYAPの間の調節ループを明らかにし,肝細胞癌に対する治療標的と同様にHippoシグナル伝達のマーカーとしてNR4A1を強調する。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 抗腫瘍作用 ,  ミトコンドリア ,  リン酸化 ,  *細胞増殖 ,  ホメオスタシス ,  肝再生 ,  肝細胞癌 ,  細胞情報伝達 ,  *アポトーシス ,  腫瘤形成
準シソーラス用語： 局在化 ,  伝達経路 ,  Hippo蛋白質 ,  治療標的 ,  Hippo経路 , 【Automatic Indexing@JST】

著者キーワード (5件)： Hippoシグナル伝達経路 ,  NR4A1 ,  アポトーシス ,  肝再生 ,  肝細胞癌(HCC)

分類 (2件)： 細胞生理一般  (EF02010S) ,  腫ようの化学・生化学・病理学  (GE02030N)

タイトルに関連する用語 (6件)： YAP ,  調節 ,  ループ ,  細胞増殖 ,  アポトーシス ,  バランス