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J-GLOBAL ID：202002270832162311   整理番号：20A2802199

APOEε4はアルツハイマー病の家族性および他のサブタイプに対して異なる効果を示す【JST・京大機械翻訳】

The APOE ε4 exerts differential effects on familial and other subtypes of Alzheimer’s disease

著者 (30件)： Jia Longfei (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Xu Hui (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Chen Shuoqi (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Wang Xiu (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Yang Jianwei (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Gong Min (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Wei Cuibai (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Tang Yi (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Qu Qiumin (Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xian, China) ,  Chu Lan (Department of Neurology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China) ,  Shen Lu (Department of Neurology, Xiangya Hospital Central South University, Changsha, China) ,  Zhou Chunkui (Department of Neurology, The First Teaching Hospital of Jilin University, Changchun, China) ,  Wang Qi (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Zhao Tan (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Zhou Aihong (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Li Ying (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Li Fangyu (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Li Yan (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Jin Hongmei (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Qin Qi (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Jiao Haishan (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Li Yan (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Zhang Heng (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Lyu Diyang (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Shi Yuqing (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Song Yang (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Jia Jianping (Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China) ,  Jia Jianping (Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China) ,  Jia Jianping (Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China) ,  Jia Jianping (Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China)
資料名： Alzheimer’s & Dementia: Journal of the Alzheimer’s Association  (Alzheimer's & Dementia: Journal of the Alzheimer's Association)
巻： 16  号： 12  ページ： 1613-1623  発行年： 2020年 
JST資料番号： W3115A  ISSN： 1552-5260  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 序論:遺伝子突然変異,散発性AD(SAD),および正常対照(NC)の有無による家族性Alzheimer病(FAD)に対するアポリポ蛋白質E(APOE)の遺伝的リスク効果は,中国人集団において不明のままである。方法:PSEN1,PSEN2,APP,TREM2,およびSORL1病原性変異(FAD[未知])のない311人のFAD患者を含む15119人の被験者;PSENs/APP変異を有する126人のFAD患者(FAD[PSENs/APP]);7234人のSAD患者;そして,7448のNCを登録した。APOEε4のリスク効果を,群を通して分析した。【結果】FAD(未知),FAD(PSENs/APP),SAD,およびNC群におけるAPOEε4遺伝子型の有病率は,それぞれ56.27%,26.19%,36.23%,および19.54%であった。さらに,APOE ε4陽性遺伝子型は,FAD(既知)リスク(オッズ比:4.51,95%信頼区間:3.57~5.45,P<0.001)に対する予測力を有した。DISCUSSION:APOE ε4陽性遺伝子型は家族性凝集を引き起こす可能性があり,この疾患のリスクを低減するためのAPOEの病理学的機能を標的とする複数の介入の検討は注意を正当化する。Copyright 2020 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 凝集 ,  遺伝子 ,  遺伝子型 ,  突然変異 ,  病原性 ,  *Alzheimer病 ,  *アポE ,  認知症
準シソーラス用語： 被験者 ,  中国人 ,  家族性アルツハイマー病 ,  遺伝的リスク ,  SORL1 , 【Automatic Indexing@JST】

著者キーワード (6件)： アルツハイマー病 ,  APOE ,  認知症 ,  遺伝子突然変異 ,  遺伝的リスク効果 ,  罹患率

分類 (2件)： 神経の基礎医学  (GN01020W) ,  先天性疾患・奇形一般  (GD03010V)

タイトルに関連する用語 (4件)： APOE ,  アルツハイマー病 ,  家族 ,  サブタイプ