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J-GLOBAL ID：202002271064444274   整理番号：20A2559945

ヒトポジティブ選択と代謝障害を結びつけるマイクロRNA【JST・京大機械翻訳】

A MicroRNA Linking Human Positive Selection and Metabolic Disorders

著者 (51件)： Wang Lifeng (Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA) ,  Wang Lifeng (Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA) ,  Sinnott-Armstrong Nasa (Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Sinnott-Armstrong Nasa (Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Wagschal Alexandre (Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA) ,  Wagschal Alexandre (Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA) ,  Wark Abigail R. (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Camporez Joao-Paulo (Departments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA) ,  Perry Rachel J. (Departments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA) ,  Ji Fei (Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA) ,  Sohn Yoojin (Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA) ,  Sohn Yoojin (Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA) ,  Oh Justin (Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA) ,  Oh Justin (Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA) ,  Wu Su (Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA) ,  Wu Su (Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA) ,  Chery Jessica (Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA) ,  Chery Jessica (Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA) ,  Moud Bahareh Nemati (Else Kroener-Fresenius-Center of Nutritional Medicine, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany) ,  Saadat Alham (Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Dankel Simon N. (Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway) ,  Dankel Simon N. (Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, 5020 Bergen, Norway) ,  Mellgren Gunnar (Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway) ,  Mellgren Gunnar (Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, 5020 Bergen, Norway) ,  Tallapragada Divya Sri Priyanka (Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway) ,  Tallapragada Divya Sri Priyanka (Hormone Laboratory, Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, 5020 Bergen, Norway) ,  Strobel Sophie Madlen (Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Strobel Sophie Madlen (Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, 80992 Munich, Germany) ,  Lee Mi-Jeong (Obesity Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA) ,  Tewhey Ryan (Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA) ,  Sabeti Pardis C. (Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Sabeti Pardis C. (Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA) ,  Schaefer Anne (Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA) ,  Petri Andreas (Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, 2450 Copenhagen, Denmark) ,  Kauppinen Sakari (Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, 2450 Copenhagen, Denmark) ,  Chung Raymond T. (Liver Center, Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA) ,  Soukas Alexander (Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Soukas Alexander (Department of Medicine, Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA) ,  Soukas Alexander (Department of Medicine, Harvard Medical School, Boston, MA 02114, USA) ,  Avruch Joseph (Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA) ,  Avruch Joseph (Department of Medicine, Harvard Medical School, Boston, MA 02114, USA) ,  Avruch Joseph (Diabetes unit, Medical Services, Massachusetts General Hospital, Boston, MA 02114, USA) ,  Fried Susan K. (Obesity Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA) ,  Hauner Hans (Else Kroener-Fresenius-Center of Nutritional Medicine, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany) ,  Hauner Hans (Institute of Nutritional Medicine, School of Medicine, Technical University of Munich, 80992 Munich, Germany) ,  Sadreyev Ruslan I. (Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA) ,  Shulman Gerald I. (Departments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA) ,  Claussnitzer Melina (Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA) ,  Claussnitzer Melina (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA) ,  Naeaer Anders M. (Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA) ,  Naeaer Anders M. (Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 183  号： 3  ページ： 684-701.e14  発行年： 2020年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： ラクターゼ遺伝子を持つ2q21.3遺伝子座におけるヨーロッパにおけるポジティブ選択は,古代のファミンを生存させるための乳を消化する成虫の能力の選択に起因する。しかし,2q21.3遺伝子座は,ヒトにおける肥満および2型糖尿病とも関連しており,遺伝子座における付加的遺伝要素が,エネルギー貯蔵を促進することにより,ファミンへの進化的適応に寄与する可能性があるが,現在,代謝性疾患に対する感受性を与える可能性がある。ここでは,正に選択された遺伝子座の中心に位置するmiR-128-1マイクロRNAが哺乳類の重要な代謝調節因子であることを示した。マウス代謝性疾患モデルにおけるmiR-128-1のアンチセンス標的化および遺伝的アブレーションは,エネルギー消費の増加および高脂肪食誘発性肥満の改善をもたらし,耐糖能を著しく改善する。miR-128-1依存性エネルギー貯蔵に接続されたトリフティ表現型は,栄養過剰量と関連するファミンおよび現代の代謝異常適応への古代適応をリンクするかもしれない。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 遺伝 ,  遺伝子 ,  ヒト ,  表現型 ,  哺乳類 ,  肥満 ,  *代謝異常 ,  栄養素過剰 ,  成虫 ,  アブレーション ,  ターゲティング ,  2型糖尿病
準シソーラス用語： ラクターゼ ,  *マイクロRNA ,  耐糖能 , 【Automatic Indexing@JST】

分類 (4件)： 遺伝子発現  (EC02040Q) ,  代謝異常・栄養性疾患一般  (GD05010J) ,  遺伝的変異  (EC01030Y) ,  遺伝学研究法  (EC01020N)

タイトルに関連する用語 (2件)： 代謝障害 ,  マイクロRNA