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J-GLOBAL ID：202002271194615816   整理番号：20A0764524

DNA損傷-停止RNAPIIのユビキチン化は転写共役修復を促進する【JST・京大機械翻訳】

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

著者 (48件)： Nakazawa Yuka (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Nakazawa Yuka (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Hara Yuichiro (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Hara Yuichiro (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Oka Yasuyoshi (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Oka Yasuyoshi (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Komine Okiru (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Komine Okiru (Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  van den Heuvel Diana (Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, the Netherlands) ,  Guo Chaowan (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Guo Chaowan (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Daigaku Yasukazu (Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan) ,  Daigaku Yasukazu (Graduate School of Life Sciences, Tohoku University, Sendai, Japan) ,  Isono Mayu (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Isono Mayu (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  He Yuxi (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  He Yuxi (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Shimada Mayuko (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Shimada Mayuko (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Kato Kana (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Kato Kana (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Jia Nan (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Jia Nan (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Hashimoto Satoru (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Hashimoto Satoru (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Kotani Yuko (Institute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Kotani Yuko (Genome Editing Research and Development (R&D) Center, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Miyoshi Yuka (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Miyoshi Yuka (Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Tanaka Miyako (Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Tanaka Miyako (Department of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Sobue Akira (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Sobue Akira (Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Mitsutake Norisato (Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan) ,  Suganami Takayoshi (Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Suganami Takayoshi (Department of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Masuda Akio (Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Ohno Kinji (Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Nakada Shinichiro (Department of Bioregulation and Cellular Response, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Nakada Shinichiro (Institute for Advanced Co-Creation Studies, Osaka University, Osaka, Japan) ,  Mashimo Tomoji (Institute of Experimental Animal Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Mashimo Tomoji (Genome Editing Research and Development (R&D) Center, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Mashimo Tomoji (Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan) ,  Yamanaka Koji (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Yamanaka Koji (Department of Neuroscience and Pathobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Luijsterburg Martijn S. (Department of Human Genetics, Leiden University Medical Center (LUMC), Leiden, the Netherlands) ,  Ogi Tomoo (Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan) ,  Ogi Tomoo (Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 180  号： 6  ページ： 1228-1244.e24  発行年： 2020年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 転写共役ヌクレオチド除去修復(TC-NER)はDNA損傷における伸長RNAポリメラーゼII(RNAPIIo)の停止により開始される。DNA損傷に応答したRNAPIIoのユビキチン化は進化的に保存されたイベントであるが,哺乳類におけるその機能は不明である。ここでは,転写回復およびDNA損傷耐性を調節する,RPB1-K1268でRNAPIIにおける単一DNA損傷誘導ユビキチン化部位を同定した。機構的には,RPB1-K1268ユビキチン化は,UVSSA-K414ユビキチン化を含む移動機構を介して,コア-TFIIH複合体と失速したRNAPIIoとの会合を刺激する。著者らは,RPB1-K1268ユビキチン化がDNA損傷における転写ボトルネックの修復と解像度に重要であることを明らかにした,鎖特異的ChIP-seq法を開発した。最後に,RPB1-K1268Rknockインマウスは短い寿命,早期老化および神経変性を示した。著者らの結果は,RNAPIIユビキチン化がTC-NERを活性化することにより2層保護機構を提供し,平行してDNA損傷-停止RNAPIIoのプロセシングをもたらすことを明らかにし,それは長い転写停止を防ぎ,神経変性に対して保護する。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 分解能 ,  *ユビキチン化 ,  感受性 ,  RNAポリメラーゼII ,  *共役 ,  *DNA損傷 ,  哺乳類 ,  防御機構 ,  複合体
準シソーラス用語： 神経変性 ,  ヌクレオチド除去修復 ,  *転写共役修復 , 【Automatic Indexing@JST】

著者キーワード (15件)： RNAポリメラーゼII ,  RNAPII ,  RNAPIIのユビキチン化 ,  転写共役修復 ,  TCR ,  ヌクレオチド除去修復 ,  NER ,  Cockayne症候群 ,  CS ,  UV感受性症候群 ,  UVSS ,  CHIP-seq ,  UVSSA ,  CRL/CSA/CSB ,  TFIIH

分類 (1件)： 生物学的機能  (EB03040U)

タイトルに関連する用語 (4件)： DNA損傷 ,  ユビキチン化 ,  転写共役修復 ,  促進