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J-GLOBAL ID：202002272080265310   整理番号：20A2059678

IL4I1はAHRを活性化し腫瘍進行を促進する代謝的免疫チェックポイントである【JST・京大機械翻訳】

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

著者 (51件)： Sadik Ahmed (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Sadik Ahmed (Faculty of Bioscience, Heidelberg University, 69120 Heidelberg, Germany) ,  Somarribas Patterson Luis F. (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Somarribas Patterson Luis F. (Faculty of Bioscience, Heidelberg University, 69120 Heidelberg, Germany) ,  Somarribas Patterson Luis F. (Department of Biochemistry, School of Medicine, University of Costa Rica (UCR), 11501-2060 San Jose, Costa Rica) ,  OEztuerk Selcen (Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Mohapatra Soumya R. (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Mohapatra Soumya R. (Faculty of Bioscience, Heidelberg University, 69120 Heidelberg, Germany) ,  Panitz Verena (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Panitz Verena (Neurology Clinic and National Center for Tumor Diseases, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Secker Philipp F. (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Pfaender Pauline (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Pfaender Pauline (Faculty of Bioscience, Heidelberg University, 69120 Heidelberg, Germany) ,  Loth Stefanie (Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, 04318 Leipzig, Germany) ,  Loth Stefanie (Institute of Organic Chemistry, Technical University Bergakademie Freiberg, 09596 Freiberg, Germany) ,  Salem Heba (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Prentzell Mirja Tamara (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Berdel Bianca (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Iskar Murat (Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Faessler Erik (Jena University Language & Information Engineering (JULIE) Lab, Friedrich-Schiller-University Jena, 07743 Jena, Germany) ,  Reuter Friederike (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Kirst Isabelle (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Kalter Verena (Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Foerster Kathrin I. (Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Jaeger Evelyn (Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, 68163 Mannheim, Germany) ,  Guevara Carina Ramallo (Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, 68163 Mannheim, Germany) ,  Sobeh Mansour (Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, 69120 Heidelberg, Germany) ,  Sobeh Mansour (AgroBioSciences Research Division, Mohammed VI Polytechnic University, 43150 Ben-Guerir, Morocco) ,  Hielscher Thomas (Division of Biostatistics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Poschet Gernot (Centre for Organismal Studies (COS), University of Heidelberg, 69120 Heidelberg, Germany) ,  Reinhardt Annekathrin (Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, and Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Hassel Jessica C. (Department of Dermatology and National Center for Tumor Diseases, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Zapatka Marc (Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Hahn Udo (Jena University Language & Information Engineering (JULIE) Lab, Friedrich-Schiller-University Jena, 07743 Jena, Germany) ,  von Deimling Andreas (Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, and Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Hopf Carsten (Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, 68163 Mannheim, Germany) ,  Schlichting Rita (Department of Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, 04318 Leipzig, Germany) ,  Escher Beate I. (Department of Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, 04318 Leipzig, Germany) ,  Burhenne Juergen (Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Haefeli Walter E. (Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Ishaque Naveed (Center for Digital Health, Charite-Universitaetsmedizin Berlin, corporate member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin and Berlin Institute of Health (BIH), 10117 Berlin, Germany) ,  Bohme Alexander (Department of Ecological Chemistry, Helmholtz Centre for Environmental Research-UFZ, 04318 Leipzig, Germany) ,  Schaeuble Sascha (Jena University Language & Information Engineering (JULIE) Lab, Friedrich-Schiller-University Jena, 07743 Jena, Germany) ,  Schaeuble Sascha (Systems Biology and Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoll Institute, 07745 Jena, Germany) ,  Thedieck Kathrin (Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, 6020 Innsbruck, Austria) ,  Thedieck Kathrin (Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands) ,  Thedieck Kathrin (Department of Neuroscience, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany) ,  Trump Saskia (Molecular Epidemiology Unit, Charite-Universitaetsmedizin Berlin, corporate member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin and Berlin Institute of Health (BIH), 10117 Berlin, Germany) ,  Seiffert Martina (Molecular Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Opitz Christiane A. (DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Opitz Christiane A. (Neurology Clinic and National Center for Tumor Diseases, Heidelberg University Hospital, 69120 Heidelberg, Germany)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 182  号： 5  ページ： 1252-1270.e34  発行年： 2020年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： トリプトファン(Trp)異化産物によるアリール炭化水素受容体(AHR)活性化は腫瘍悪性腫瘍を増強し,抗腫瘍免疫を抑制する。AHR標的遺伝子の文脈特異性は,これまでAHR活性とその上流酵素のヒト癌にわたる系統的研究を妨げている。自然言語処理により誘導される汎組織AHRシグネチャーは,32の腫瘍実体全体で,インターロイキン-4誘導-1(IL4I1)がIDO1またはTDO2よりAHR活性とより頻繁に会合し,これまで主なTrp-異化酵素として認識されることを明らかにした。IL4I1はインドール代謝産物とキヌレン酸の生成を介してAHRを活性化する。それは,神経膠腫患者における生存率の低下と関係し,癌細胞運動性を促進し,適応免疫を抑制し,それによってマウスにおける慢性リンパ球性白血病(CLL)の進行を増強する。免疫チェックポイント遮断(ICB)はIDO1とIL4I1を誘導する。IDO1阻害剤はIL4I1を遮断しないので,IL4I1はICBとIDO1阻害を組み合わせた臨床研究の失敗を説明するかもしれない。まとめると,IL4I1遮断は癌治療の新しい道を開く。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 酵素 ,  異化 ,  *腫瘍 ,  代謝産物 ,  ヒト ,  生存率 ,  神経膠腫 ,  インターロイキン4 ,  腫瘍免疫 ,  適応免疫 ,  窒素複素環化合物 ,  芳香族縮合化合物 ,  ヒドロキシ酸 ,  アミノ酸 ,  第一アミン
準シソーラス用語： 悪性腫瘍 ,  *腫瘍進行 ,  癌治療 , 【Automatic Indexing@JST】

著者キーワード (10件)： AHR ,  アリール炭化水素受容体 ,  IL4I1 ,  インターロイキン4誘導1 ,  T細胞消耗 ,  トリプトファン代謝 ,  腫瘍微小環境 ,  適応免疫 ,  キヌレン酸 ,  CLL

分類 (1件)： 生物学的機能  (EB03040U)

物質索引 (2件)： キヌレン酸 ,  トリプトファン

タイトルに関連する用語 (7件)： AhR ,  活性化 ,  腫瘍進行 ,  促進 ,  代謝 ,  免疫 ,  チェックポイント