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J-GLOBAL ID：202002272270764822   整理番号：20A1420440

m=6A修飾は造血発生時の内因性二本鎖RNAの形成と有害な自然免疫応答を阻止する【JST・京大機械翻訳】

m⁶A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development

著者 (48件)： Gao Yimeng (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Gao Yimeng (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Vasic Radovan (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Vasic Radovan (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Song Yuanbin (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Song Yuanbin (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Teng Rhea (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Teng Rhea (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Liu Chengyang (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Liu Chengyang (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Gbyli Rana (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Gbyli Rana (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Biancon Giulia (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Biancon Giulia (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Nelakanti Raman (Department of Genetics and Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Lobben Kirsten (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Lobben Kirsten (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Kudo Eriko (Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA) ,  Kudo Eriko (Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Liu Wei (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Liu Wei (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Ardasheva Anastasia (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Ardasheva Anastasia (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Fu Xiaoying (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Fu Xiaoying (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Wang Xiaman (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Wang Xiaman (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Joshi Poorval (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Joshi Poorval (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Lee Veronica (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Lee Veronica (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Dura Burak (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Dura Burak (Department of Biomedical Engineering and Yale Cancer Center, Yale University, New Haven, CT 06520, USA) ,  Viero Gabriella (Institute of Biophysics, CNR Unit at Trento, Povo Trento 38123, Italy) ,  Iwasaki Akiko (Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA) ,  Iwasaki Akiko (Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Iwasaki Akiko (Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA) ,  Fan Rong (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Fan Rong (Department of Biomedical Engineering and Yale Cancer Center, Yale University, New Haven, CT 06520, USA) ,  Xiao Andrew (Department of Genetics and Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Flavell Richard A. (Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Flavell Richard A. (Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA) ,  Li Hua-Bing (Shanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China) ,  Li Hua-Bing (Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China) ,  Tebaldi Toma (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Tebaldi Toma (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Halene Stephanie (Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA) ,  Halene Stephanie (Yale Stem Cell Center and Yale RNA Center, Yale University School of Medicine, New Haven, CT 06520, USA)
資料名： Immunity  (Immunity)
巻： 52  号： 6  ページ： 1007-1021.e8  発行年： 2020年 
JST資料番号： W1727A  ISSN： 1074-7613  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： N6-メチルアデノシン(m6A)は最も豊富なRNA修飾であるが,哺乳類造血発生におけるその役割についてはほとんど知られていない。ここでは,マウス胎児肝臓におけるm6A書き込みMETTL3の条件付き欠失が造血不全および周産期致死を生じることを示す。METTL3とm6Aの消失は,内因性二本鎖RNA(dsRNA)の形成により媒介される異常な先天性免疫応答を活性化した。異常に形成されるdsRNAは長く,高度にm6Aは天然状態で修飾され,低折畳みエネルギー及び主に蛋白質コードにより特性化された。外来dsRNAの検出で通常タスクされたパターン認識受容体経路の同時活性化を同定した。下流MavsまたはRnaselシグナリングの抑止を介した異常な免疫応答の破壊は,in vitroおよびin vivoでMETTL3欠損細胞での観察された造血欠損を部分的に救済した。著者らの結果は,m6A修飾が哺乳類造血発生時に内因性dsRNA形成と有害な先天性免疫応答から保護することを示唆する。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： タンパク質 ,  哺乳類 ,  *免疫反応 ,  折畳み ,  *造血 ,  キャラクタリゼーション ,  周産期 ,  in vitro実験 ,  *自然免疫 ,  *二本鎖RNA
準シソーラス用語： *内因性 ,  パターン認識受容体 ,  RNA修飾 ,  胎児肝臓 ,  共活性化 , 【Automatic Indexing@JST】

著者キーワード (10件)： 自然免疫応答 ,  dsRNA ,  RNA修飾 ,  N6-メチルアデノシン ,  METTL3 ,  造血の発達 ,  m6A ,  エピトランスクリプトーム ,  造血 ,  二本鎖RNA

分類 (4件)： 細胞膜の受容体  (EF04030C) ,  腫ようの化学・生化学・病理学  (GE02030N) ,  分子構造  (EB03020Y) ,  酵素一般  (EB09010D)

タイトルに関連する用語 (6件)： 修飾 ,  造血 ,  内因性 ,  二本鎖RNA ,  自然免疫応答 ,  阻止