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J-GLOBAL ID：202002277318607316   整理番号：20A0584498

JAK2の遮断は肺動脈平滑筋細胞増殖抑制により低酸素誘発肺動脈高血圧症に対してマウスを保護する【JST・京大機械翻訳】

Blockade of JAK2 protects mice against hypoxia-induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation

著者 (27件)： Zhang Lei (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Zhang Lei (Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Wang Yi (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Wang Yi (Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Wu Guorao (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Wu Guorao (Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Rao Lizong (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Rao Lizong (Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China) ,  Wei Yanqiu (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Wei Yanqiu (Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Yue Huihui (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Yue Huihui (Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Yuan Ting (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Yuan Ting (Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China) ,  Yang Ping (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Xiong Fei (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Zhang Shu (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Zhou Qing (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Chen Zhishui (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Li Jinxiu (Shenzhen Third People’s Hospital, Shenzhen, China) ,  Mo Bi-Wen (Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Guilin Medical University, Guilin, China) ,  Zhang Huilan (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Zhang Huilan (Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Xiong Weining (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...) ,  Xiong Weining (Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Xiong Weining (Department of Respiratory Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China) ,  Wang Cong-Yi (Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Ministry of Education, The Center for Biomedical Research, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Sc...)
資料名： Cell Proliferation  (Cell Proliferation)
巻： 53  号： 2  ページ： e12742  発行年： 2020年 
JST資料番号： T0301A  ISSN： 0960-7722  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 目的:低酸素は肺動脈高血圧(PAH)における肺動脈再モデル化の重要な危険因子であり,Janusキナーゼ2(JAK2)はこの過程に関与すると信じられている。本報告では,PAHの過程における血管平滑筋細胞におけるJAK2の役割を調べることを目的とした。【方法】平滑筋細胞(SMC)特異的Jak2欠損マウスおよびそれらの同腹子対照を,それぞれ,PAHの発生をモニターするために,28日間,正常圧正常酸素または低酸素(10%O_2)チャレンジを受けた。JAK2が肺血管再モデル化に影響する可能性のある機構をさらに解明するため,選択的JAK2阻害剤を用いてヒト肺動脈平滑筋細胞(HPASMC)を1時間前処理し,続いて24時間低酸素曝露を行った。【結果】低酸素によって誘発されたPAHを有するマウスは,肺動脈平滑筋細胞におけるJAK2/STAT3活性の変化によって特徴付けられた。従って,SMCにおけるJak2欠損の誘導は,右心室収縮期圧(RVSP)の低酸素誘導増加,右室肥大および肺血管再モデル化からマウスを保護した。特に,Jak2の損失は肺における慢性低酸素誘導PASMC増殖を有意に減弱した。同様に,阻害剤TG-101348によるJAK2の遮断は低酸素誘導ヒトPASMC増殖を抑制した。低酸素誘導活性化において,JAK2はシグナル伝達物質と転写3(STAT3)の活性化因子をリン酸化し,その後,CCNA2プロモーターに結合してサイクリンA2発現を転写し,それによりPASMC増殖を促進した。結論:著者らの研究は,JAK2が肺血管再モデル化に寄与する責任であり,したがって,それは臨床設定におけるPAHの予防と治療のための実行可能な標的になり得ることを支持する。Copyright 2020 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 収縮期血圧 ,  前処理 ,  リン酸化 ,  危険因子 ,  ヒト ,  *増殖阻害 ,  プロモーター領域 ,  血管平滑筋細胞 ,  細胞情報伝達 ,  *酸素欠乏 ,  *平滑筋細胞 ,  *肺動脈
準シソーラス用語： 肺血管 ,  *肺動脈平滑筋細胞 ,  *Janusキナーゼ2 , 【Automatic Indexing@JST】

著者キーワード (5件)： サイクリンA2 ,  Janusキナーゼ2 ,  肺動脈高血圧症 ,  肺動脈平滑筋細胞 ,  転写3のシグナル伝達物質と活性化因子

分類 (1件)： 細胞生理一般  (EF02010S)

タイトルに関連する用語 (8件)： JAK2 ,  遮断 ,  肺動脈平滑筋細胞 ,  増殖抑制 ,  低酸素 ,  誘発 ,  肺動脈高血圧症 ,  マウス