文献

J-GLOBAL ID：202002277552188283   整理番号：20A1517354

慢性塞栓性肺高血圧症のイヌモデルに経口投与した単回投与シルデナフィルの薬物動態

Pharmacokinetics of single dose sildenafil orally administered in canine models of chronic embolic pulmonary hypertension

著者 (9件)： AKABANE Ryota (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  SATO Touko (Laboratory of Biomolecular Chemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  SAKATANI Atsushi (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  OGAWA Mizuki (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  NAGAKAWA Masayoshi (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  MIYAKAWA Hirosumi (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  MIYAGAWA Yuichi (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  TAZAKI Hiroyuki (Laboratory of Biomolecular Chemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan) ,  TAKEMURA Naoyuki (Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan)
資料名： Journal of Veterinary Medical Science (Web)  (Journal of Veterinary Medical Science (Web))
巻： 82  号： 4  ページ： 446-451(J-STAGE)  発行年： 2020年 
JST資料番号： U1094A  ISSN： 1347-7439  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： 肺高血圧症のイヌにおける経口シルデナフィルの薬物動力学に関す...

シソーラス用語： *血栓塞栓症 ,...
準シソーラス用語： PDE5阻害剤 ,...

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著者キーワード (5件)： イヌ ,  ミクロスフェア ,  薬物動態 ,  肺高血圧症 ,  シルデナフィル

分類 (3件)： その他の動物病  (FE02060T) ,  動物用医薬品  (FE01050B) ,  循環系の基礎医学  (GJ01020K)

物質索引 (1件)： シルデナフィル

引用文献 (29件)：

• 1. Akabane, R., Sato, T., Sakatani, A., Miyagawa, Y., Tazaki, H. and Takemura, N. 2018. Pharmacokinetics of single-dose sildenafil administered orally in clinically healthy dogs: Effect of feeding and dose proportionality. J. Vet. Pharmacol. Ther. 41: 457-462.
• 2. Al-Mohizea, A. M., Ahad, A., El-Maghraby, G. M., Al-Jenoobi, F. I., AlKharfy, K. M. and Al-Suwayeh, S. A. 2015. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. Eur. J. Drug Metab. Pharmacokinet. 40: 219-224.
• 3. Bach, J. F., Rozanski, E. A., MacGregor, J., Betkowski, J. M. and Rush, J. E. 2006. Retrospective evaluation of sildenafil citrate as a therapy for pulmonary hypertension in dogs. J. Vet. Intern. Med. 20: 1132-1135.
• 4. Borgarelli, M., Abbott, J., Braz-Ruivo, L., Chiavegato, D., Crosara, S., Lamb, K., Ljungvall, I., Poggi, M., Santilli, R. A. and Haggstrom, J. 2015. Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease. J. Vet. Intern. Med. 29: 569-574.
• 5. Brown, A. J., Davison, E. and Sleeper, M. M. 2010. Clinical efficacy of sildenafil in treatment of pulmonary arterial hypertension in dogs. J. Vet. Intern. Med. 24: 850-854.

タイトルに関連する用語 (9件)： 慢性 ,  塞栓 ,  肺高血圧症 ,  イヌ ,  モデル ,  経口投与 ,  単回投与 ,  シルデナフィル ,  薬物動態