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J-GLOBAL ID：202002279456090719   整理番号：20A2729349

頭蓋脳損傷を伴う1段階修復大頭蓋欠損に対する弾性自己骨パッチ【JST・京大機械翻訳】

An elastic auto-bone patch for one-step repair large skull defects accompanied by Craniocerebral injury

著者 (32件)： Liao Youguo (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Liao Youguo (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Liao Youguo (Guangxi Collaborative Innovation Center for Biomedicine, Guangxi Medical University, Nanning, Guangxi, 530021, China) ,  He Qiulin (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  He Qiulin (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Zhou Feifei (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Zhou Feifei (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Hong Yi (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Hong Yi (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Wu Xinyu (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Wu Xinyu (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Wu Haoyu (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Wu Haoyu (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Zhang Xianzhu (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Zhang Xianzhu (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Bunpetch Varitsara (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Bunpetch Varitsara (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Zhang Jingwei (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Zhang Jingwei (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Ye Guo (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Ye Guo (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Shen Weiliang (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Shen Weiliang (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Shen Weiliang (Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China) ,  Shen Weiliang (China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China) ,  Zhang Shufang (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Zhang Shufang (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Zhang Shufang (China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China) ,  Ouyang Hongwei (Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China) ,  Ouyang Hongwei (Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China) ,  Ouyang Hongwei (Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China) ,  Ouyang Hongwei (China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China)
資料名： Applied Materials Today  (Applied Materials Today)
巻： 20  ページ： Null  発行年： 2020年 
JST資料番号： W3082A  ISSN： 2352-9407  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 頭蓋脳損傷を伴う大面積頭蓋欠損は,損傷と頭蓋内高血圧の広域のため治療が困難な生命回復疾患である。自家骨は頭蓋欠損を含む骨再生のための理想的な源である。しかし,頭蓋切除と頭蓋形成術を含む2段階治療は,頭蓋内圧を安定化させるための臨床診療における主要な戦略であるが,まだ,自己骨断片の保存と曝露脳組織の保護の両方で大きな障害のままである。本研究では,弾性自己骨パッチを開発し,現在,手術の2段階で修復される大きな頭蓋欠損を修復するための新しい1段階法を提供した。弾性自己骨パッチは,ヒドロゲルを用いて自己骨断片を接着することにより形成され,その後,大きな頭蓋骨欠損を修復するために骨欠損に再注入される。自家骨パッチは,損傷の脳組織を保護し,周囲の骨組織と良く統合し,骨再生を促進する頭蓋内圧の変化に適応できる。8週間の移植後,大サイズの頭蓋欠損は,自己骨パッチで治療する群で,新しく形成された骨組織で満たされた。本研究は,大面積頭蓋骨欠損を修復するための弾性自己骨パッチの応用に関する新しい手順を紹介した。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *弾性 ,  高血圧症 ,  ヒドロゲル ,  頭蓋内圧
準シソーラス用語： 骨再生 ,  骨組織 ,  自家骨 ,  脳組織 ,  骨欠損 ,  *頭蓋骨欠損 , 【Automatic Indexing@JST】

著者キーワード (4件)： 自動骨パッチ ,  頭蓋骨欠損 ,  頭蓋脳外傷 ,  骨再生

分類 (2件)： 医用画像処理  (JE04020T) ,  医用素材  (GA05040H)

タイトルに関連する用語 (7件)： 頭蓋脳損傷 ,  段階 ,  修復 ,  頭蓋欠損 ,  弾性 ,  自己 ,  パッチ