文献

J-GLOBAL ID：202002280667807909   整理番号：20A0615439

チアノーゼおよび非チアノーゼ性先天性心疾患の小児における経胸壁心エコー検査のための鼻内デクスメデトミジン鎮静の50%有効用量【JST・京大機械翻訳】

Fifty Percent Effective Dose of Intranasal Dexmedetomidine Sedation for Transthoracic Echocardiography in Children With Cyanotic and Acyanotic Congenital Heart Disease

著者 (15件)： Yang Fei (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Li Shangyingying (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Shi Yuan (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Liu Lu (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Ye Mao (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Zhang Jin (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Liu Hui (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Liu Feng (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Yu Qing (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Yu Qing (Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Chongqing, China) ,  Sun Mang (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Sun Mang (Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Chongqing, China) ,  Tian Qin (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Tu Shengfen (Department of Anesthesiology, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders (Chongqing); China International Science and Technology Cooperation ...) ,  Tu Shengfen (Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Chongqing, China)
資料名： Journal of Cardiothoracic and Vascular Anesthesia  (Journal of Cardiothoracic and Vascular Anesthesia)
巻： 34  号： 4  ページ： 966-971  発行年： 2020年 
JST資料番号： W0009A  ISSN： 1053-0770  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 目的:チアノーゼおよび非チアノーゼ性先天性心疾患の小児における経胸壁心エコーに対する鼻腔内デキスメデトミジン鎮静の50%および95%有効用量を測定すること。前向き,非無作為化研究。三次治療教育病院。18か月未満の患者は,鎮静による経胸壁心エコー検査のために予定されている,または疑われた先天性心疾患を有する。患者をチアノーゼ群(血液酸素飽和<85%)または非チアノーゼ性群(血液酸素飽和≧85%)に分割した。本研究では,Dixonのアップアンドダウン法逐次配置設計を用いた。両群において,鼻腔内デキスメデトミジンの初期投与量は2μg/kgであり,増加または減少の勾配は0.25μg/kgであった。経胸壁心エコー法に対する鼻腔内デキスメデトミジン鎮静の50%有効用量(95%信頼区間)は,シアンおよび非チアノーゼ性群においてそれぞれ3.2(2.78~3.55)μg/kgおよび1.9(1.69~2.06)μg/kgであった。患者のいずれも,有意な有害事象を経験しなかった。経胸壁心エコーに対する鼻腔内デキスメデトミジン鎮静の50%(95%信頼区間)有効用量は,チアノーゼおよび非チアノーゼ性先天性心疾患の小児において,それぞれ3.2(2.78~3.55)μg/kgおよび1.9(1.69~2.06)μg/kgであった。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *チアノーゼ ,  配置設計 ,  シアン ,  *子供 ,  先天性心疾患 ,  窒素複素環化合物 ,  芳香族化合物
準シソーラス用語： 有害事象 ,  *経胸壁心エコー法 , 【Automatic Indexing@JST】

著者キーワード (3件)： デキスメデトミジン ,  鎮静 ,  経胸壁心エコー検査

分類 (2件)： 循環系の診断  (GJ02000V) ,  循環系疾患の外科療法  (GJ05030X)

物質索引 (1件)： デキスメデトミジン

タイトルに関連する用語 (9件)： チアノーゼ ,  非チアノーゼ性先天性心疾患 ,  小児 ,  経胸壁心エコー ,  検査 ,  鼻 ,  デクスメデトミジン ,  鎮静 ,  有効用量