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J-GLOBAL ID：202002283210828668   整理番号：20A1356562

オートファジーはin vivoでのアヒルTembusuウイルス感染に対する潜在的な治療標的である【JST・京大機械翻訳】

Autophagy Is a Potential Therapeutic Target Against Duck Tembusu Virus Infection in vivo

著者 (67件)： Hu Zhiqiang (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Hu Zhiqiang (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Hu Zhiqiang (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Pan Yuhong (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Pan Yuhong (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Pan Yuhong (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Cheng Anchun (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Cheng Anchun (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Cheng Anchun (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Zhang Xingcui (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Zhang Xingcui (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Zhang Xingcui (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Wang Mingshu (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Wang Mingshu (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Wang Mingshu (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Chen Shun (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Chen Shun (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Chen Shun (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Zhu Dekang (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Zhu Dekang (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Zhu Dekang (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Liu Mafeng (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Liu Mafeng (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Liu Mafeng (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Yang Qiao (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Yang Qiao (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Yang Qiao (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Wu Ying (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Wu Ying (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Wu Ying (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Zhao Xinxin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Zhao Xinxin (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Zhao Xinxin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Huang Juan (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Huang Juan (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Huang Juan (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Zhang Shaqiu (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Zhang Shaqiu (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Zhang Shaqiu (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Mao Sai (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Mao Sai (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Mao Sai (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Ou Xumin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Ou Xumin (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Ou Xumin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Yu Yanling (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Yu Yanling (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Yu Yanling (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Zhang Ling (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Zhang Ling (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Zhang Ling (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Liu Yunya (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Liu Yunya (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Liu Yunya (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Tian Bin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Tian Bin (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Tian Bin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Pan Leichang (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Pan Leichang (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Pan Leichang (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Rehman Mujeeb Ur (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Rehman Mujeeb Ur (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Rehman Mujeeb Ur (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Yin Zhongqiong (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China) ,  Jia Renyong (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China) ,  Jia Renyong (Avian Disease Research Center, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang, China) ,  Jia Renyong (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, China)
資料名： Frontiers in Cellular and Infection Microbiology (Web)  (Frontiers in Cellular and Infection Microbiology (Web))
巻： 10  ページ： 155  発行年： 2020年 
JST資料番号： U7063A  ISSN： 2235-2988  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： Duck tembusuウイルス(DTMUV)は,家禽で新しく出現し,中国および近隣諸国における育種産業に大きな損失を引き起こす。効果的な抗ウイルス戦略はまだ研究されている。オートファジーは細胞分解経路であり,著者らの研究室の以前のデータはオートファジーがin vitroでDTMUV複製を促進することを示す。さらにin vivoでのオートファジーの役割を研究するために,DTMUV標的組織におけるオートファジー応答を調べるために動物モデルとしてアヒルを利用した。また,オートファジーエンハンサーとしてRapamycin(Rapa),オートファジー阻害剤として3-メチルアデニン(3-MA)およびクロロキン(CQ)を含むオートファジー調節因子を用い,宿主オートファジーレベルを調整し,組織損傷およびウイルス複製に及ぼすオートファジーの影響を調べた。その結果,著者らは最初に,DTMUV感染トリggedオートファジーとオートファジー調節剤処理がアヒル脾臓と脳でオートファジーレベルをうまく調節することを見出した。次に,オートファジー阻害剤はDTMUV複製を阻害し,DTMUV誘導の病理学的症状を緩和し,オートファジー誘導剤処理は反対の効果をもたらすことを見出した。また,オートファジー調節は,パターン認識受容体,I型インターフェロンおよびサイトカインを含む先天性免疫遺伝子の発現と相関し,異なる組織において異なる効果を引き起こすことを見出した。要約すると,オートファジーがDTMUV複製を促進し,病理学的症状の発達を悪化させ,おそらくin vivoでの宿主の先天性免疫応答を相殺することを実証した。Copyright 2020 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 遺伝子 ,  *ウイルス感染 ,  脾臓 ,  *アヒル ,  育種 ,  家禽 ,  ウイルス複製 ,  サイトカイン ,  in vitro実験 ,  自然免疫 ,  *オートファジー
準シソーラス用語： 動物モデル ,  調節因子 ,  パターン認識受容体 ,  *治療標的 , 【Automatic Indexing@JST】

著者キーワード (7件)： DTMUV ,  オートファジー ,  脾臓 ,  脳 ,  組織損傷 ,  複製 ,  免疫応答

分類 (2件)： 細胞生理一般  (EF02010S) ,  ウイルス感染の生理と病原性  (EG04042Y)

引用文献 (68件)：

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タイトルに関連する用語 (4件)： オートファジー ,  アヒル ,  ウイルス感染 ,  治療標的