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J-GLOBAL ID：202002283716509680   整理番号：20A1724996

遺伝子-遺伝子相互作用および主要効果を有するエピジェネティックおよび転写バイオマーカーを組み込んだ早期非小細胞肺癌予後スコアの独立検証【JST・京大機械翻訳】

Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effects

著者 (51件)： Zhang Ruyang (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Zhang Ruyang (Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA) ,  Zhang Ruyang (China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China) ,  Zhang Ruyang (Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China) ,  Chen Chao (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Dong Xuesi (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Dong Xuesi (Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA) ,  Dong Xuesi (Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, China) ,  Shen Sipeng (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Shen Sipeng (Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA) ,  Shen Sipeng (China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China) ,  Lai Linjing (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  He Jieyu (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  You Dongfang (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  You Dongfang (Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA) ,  Lin Lijuan (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Lin Lijuan (Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA) ,  Zhu Ying (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Huang Hui (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Chen Jiajin (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Wei Liangmin (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Chen Xin (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Li Yi (Department of Biostatistics, University of Michigan, Ann Arbor, MI) ,  Guo Yichen (Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA) ,  Guo Yichen (Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA) ,  Duan Weiwei (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Duan Weiwei (Department of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China) ,  Liu Liya (Department of Preventive Medicine, Medical School of Ningbo University, Ningbo, China) ,  Su Li (Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA) ,  Shafer Andrea (Pulmonary and Critical Care Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA) ,  Fleischer Thomas (Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway) ,  Moksnes Bjaanaes Maria (Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway) ,  Karlsson Anna (Division of Oncology and Pathology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden) ,  Planck Maria (Division of Oncology and Pathology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden) ,  Wang Rui (Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China) ,  Staaf Johan (Division of Oncology and Pathology, Department of Clinical Sciences, Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden) ,  Helland Åslaug (Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway) ,  Helland Åslaug (Institute of Clinical Medicine, University of Oslo, Oslo, Norway) ,  Esteller Manel (Josep Carreras Leukemia Research Institute, Badalona, Barcelona, Spain) ,  Esteller Manel (Centro de Investigacion Biomedica en Red Cancer, Madrid, Spain) ,  Esteller Manel (Institucio Catalana de Recerca i Estudis Avancats, Barcelona, Spain) ,  Esteller Manel (Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain) ,  Wei Yongyue (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Wei Yongyue (Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA) ,  Wei Yongyue (China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China) ,  Chen Feng (Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China) ,  Chen Feng (China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China) ,  Chen Feng (State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China) ,  Chen Feng (Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China) ,  Christiani David C. (Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA) ,  Christiani David C. (Pulmonary and Critical Care Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA)
資料名： Chest  (Chest)
巻： 158  号： 2  ページ： 808-819  発行年： 2020年 
JST資料番号： D0800B  ISSN： 0012-3692  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： DNAメチル化と遺伝子発現は,非小細胞肺癌(NSCLC)を含む様々な癌の有望なバイオマーカーである。バイオマーカーの主な効果の他に,複合疾患の進行も遺伝子(G×G)相互作用により影響される。マルチミクスデータを使用して,主要な効果または相互作用に基づいてバイオマーカーの機能的能力をスクリーニングすることは,癌予後の精度を改善する。バイオマーカースクリーニングとモデル検証を用いて,予測モデルを構築し,検証した。NSCLCの予後関連バイオマーカーを,それらの主な効果または2種類のオミクスデータとの相互作用に基づいて同定した。臨床情報と同様に,エピジェネティックおよび転写バイオマーカーを組み込んだ予後スコアを独立して検証した。G×G相互作用を有する26対のバイオマーカーと主な影響を有する2つのバイオマーカーは,NSCLC生存と有意に関連していた。臨床情報のみを用いたモデルと比較して,受信者動作特性曲線(AUC)下の面積で測定したエピジェネティックおよび転写バイオマーカーベースの予後モデルの精度は,それぞれ3および5年生存に対して35.38%(95%CI,27.09%~42.17%,P=5.10×10-17)および34.85%(95%CI,26.33%~41.87%;P=2.52×10-18)増加し,独立癌ゲノムアトラス集団におけるNSCLC生存(AUC_3年,0.88[95%CI,0.83~0.93]およびAUC_5年,0.89[95%CI,0.83~0.93)]に対する優れた予測能力を示した。G×G相互作用は,それぞれ3年および5年生存率の予測精度の65.2%および91.3%の増加に寄与した。主な効果およびG×G相互作用と後成的および転写バイオマーカーの統合は,初期段階NSCLC生存の予後予測の精度を有意に改善する。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *相互作用 ,  *遺伝子 ,  *予後 ,  スクリーニング ,  遺伝子発現 ,  *非小細胞肺癌 ,  *バイオマーカー ,  予測モデル ,  *エピジェネティクス
準シソーラス用語： ROC曲線 ,  DNAメチル化 ,  モデル検証 ,  予測精度 ,  予後予測 ,  オミックス , 【Automatic Indexing@JST】

著者キーワード (5件)： 初期段階 ,  相互作用 ,  マルチオミクス ,  非小細胞肺癌 ,  予後スコア

分類 (3件)： 腫ようの診断  (GE03020J) ,  腫ようの化学・生化学・病理学  (GE02030N) ,  遺伝子発現  (EC02040Q)

タイトルに関連する用語 (9件)： 遺伝子-遺伝子相互作用 ,  エピジェネティック ,  転写 ,  バイオマーカー ,  早期 ,  非小細胞肺癌 ,  予後 ,  スコア ,  検証