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J-GLOBAL ID：202002283822536771   整理番号：20A2089786

眼科治療への応用のための刺激応答性および架橋ナノヒドロゲルのキャラクタリゼーション【JST・京大機械翻訳】

Characterization of stimuli-responsive and cross-linked nanohydrogels for applications in ophthalmiatrics therapy

著者 (49件)： Chen Shihong (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Chen Shihong (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Chen Shihong (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Jia Huanhuan (Guangdong Laboratory, Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou, People’s Republic of China) ,  Cui Xuehui (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Cui Xuehui (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Cui Xuehui (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Zhang Yan (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Zhang Yan (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Zhang Yan (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Wen Yu (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Wen Yu (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Wen Yu (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Ding Yiwei (Shenyang Pharmaceutical University, Shenyang, People’s Republic of China) ,  Xie Qingchun (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Xie Qingchun (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Xie Qingchun (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Lin Ying (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Lin Ying (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Lin Ying (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Xiao Feng (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Xiao Feng (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Xiao Feng (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Lin Xinliang (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Lin Xinliang (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Lin Xinliang (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Wu Hao (Tianhe Wushan Huanong Community Health Service Center, South China Agricultural University, Guangzhou, People’s Republic of China) ,  Mo Zhenjie (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Mo Zhenjie (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Mo Zhenjie (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Zheng Kangyu (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Zheng Kangyu (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Zheng Kangyu (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Qiu Jindi (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Qiu Jindi (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Qiu Jindi (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Wen Yuqin (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Wen Yuqin (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Wen Yuqin (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Ni Qingchun (Guangzhou General Pharmaceutical Research Institute Co, Ltd, Guangzhou, People’s Republic of China) ,  Ban Junfeng (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Ban Junfeng (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Ban Junfeng (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Chen Yanzhong (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Chen Yanzhong (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Chen Yanzhong (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Lu Zhufen (Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Lu Zhufen (Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China) ,  Lu Zhufen (R&D Innovation Team for Controlled-Release Microparticle Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China)
資料名： Applied Nanoscience  (Applied Nanoscience)
巻： 10  号： 9  ページ： 3465-3475  発行年： 2020年 
JST資料番号： W6363A  ISSN： 2190-5517  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 高い薬物負荷容量にもかかわらず,従来のナノ点眼剤の眼表面保持と角膜透過性はまだ不十分であり,それによって治療有効性を制限する。したがって,本研究の目的は,カプセル化薬物の眼表面保持と角膜透過性を高めるために,刺激応答要素を組み込むことによって,デキサメタゾン負荷温度感受性,pH感受性およびイオン感受性ナノゲルを処方することであった。ナノゲルは優れたレオロジー特性を示し,生理学的条件下で良好な強度と粘度を示した。in vitroおよびin vivo研究の両者は,ナノゲルが薬物の眼表面保持および角膜透過性を増強することを示した。温度感受性ゲルは最適挙動を示した。刺激応答性ナノゲルは,標的および持続的方法で後部眼セグメントに薬剤を放出することができる安定なデリバリーシステムである。Copyright King Abdulaziz City for Science and Technology 2020 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： イオン ,  粘度 ,  *ゲル ,  感受性 ,  点眼剤 ,  *眼科学 ,  in vitro実験 ,  温度感受性 ,  ステロイド ,  ステロイドホルモン ,  ジエン ,  有機フッ素化合物 ,  グルココルチコイド ,  エノン ,  脂環式アルコール ,  脂環式ケトン ,  ジケトン ,  第二アルコール ,  ヒドロキシケトン ,  ポリオール
準シソーラス用語： ナノゲル ,  徐放性 ,  薬物負荷 ,  *刺激応答 ,  レオロジー特性 ,  眼表面 , 【Automatic Indexing@JST】

著者キーワード (4件)： 刺激応答性ナノゲルデリバリーシステム ,  浸透率の向上 ,  保持強化 ,  徐放性効果

分類 (5件)： コロイド化学一般  (CB11010C) ,  製剤一般  (GY02010Z) ,  固体デバイス製造技術一般  (NC03030V) ,  共重合  (CG04030D) ,  高分子固体の構造と形態学  (CG02022M)

物質索引 (1件)： デキサメタゾン

タイトルに関連する用語 (7件)： 眼科 ,  治療 ,  応用 ,  刺激応答性 ,  架橋 ,  ヒドロゲル ,  キャラクタリゼーション