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J-GLOBAL ID：202002289557346723   整理番号：20A2794981

細菌感染に対する免疫応答におけるナイルティラピア(Oreochromis niloticus)からのガレクチン-2のin vivoでの役割【JST・京大機械翻訳】

The in vivo roles of galectin-2 from Nile tilapia (Oreochromis niloticus) in immune response against bacterial infection

著者 (22件)： Niu Jinzhong (College of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animal, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Southern Marine Science and Engineerin...) ,  Liu Xinchao (College of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animal, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Southern Marine Science and Engineerin...) ,  Zhang Zhiqiang (College of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animal, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Southern Marine Science and Engineerin...) ,  Huang Yu (College of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animal, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Southern Marine Science and Engineerin...) ,  Huang Yu (Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China) ,  Huang Yu (Guangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, 518120, China) ,  Tang Jufen (College of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animal, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Southern Marine Science and Engineerin...) ,  Tang Jufen (Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China) ,  Tang Jufen (Guangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, 518120, China) ,  Wang Bei (College of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animal, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Southern Marine Science and Engineerin...) ,  Wang Bei (Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China) ,  Wang Bei (Guangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, 518120, China) ,  Lu Yishan (College of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animal, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Southern Marine Science and Engineerin...) ,  Lu Yishan (Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China) ,  Lu Yishan (Guangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, 518120, China) ,  Cai Jia (College of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animal, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Southern Marine Science and Engineerin...) ,  Cai Jia (Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China) ,  Cai Jia (Guangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, 518120, China) ,  Cai Jia (Guangxi Key Lab for Marine Natural Products and Combinational Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Centre, Guangxi Academy of Sciences, Nanning, China) ,  Jian Jichang (College of Fishery, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animal, Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Southern Marine Science and Engineerin...) ,  Jian Jichang (Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China) ,  Jian Jichang (Guangdong Provincial Engineering Research Center for Aquatic Animal Health Assessment, Shenzhen, 518120, China)
資料名： Fish & Shellfish Immunology  (Fish & Shellfish Immunology)
巻： 106  ページ： 473-479  発行年： 2020年 
JST資料番号： W1617A  ISSN： 1050-4648  資料種別： 逐次刊行物 (A)
記事区分： 短報  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 著者らの以前の研究は,ナイルティラピア(Oreochromisガラクトサミン)ガレクチン-2(rOnGal-2)の組換蛋白質がin vitroでStreptococcus agalactiae(S.agalactiae)感染に対する免疫応答を増強できることを報告した。本研究では,in vivoでの細菌感染に対する免疫応答におけるOnGal-2の影響を調べた。rOnGal-2投与は,血清抗菌活性(ALKP,ACPおよびLZM)および抗酸化能(CAT,PODおよびSOD)を改善することができた。S.agalactiae感染の後,rOnGal-2注射は,ティラピアの頭腎,脾臓および肝臓における細菌負荷を減少させ,組織損傷を減少させることができた。また,rOnGal-2は,細菌感染時にIL-6,IL-8およびIL-10を含む炎症関連遺伝子発現を調節した。さらに,rOnGal-2投与は,S.agalactiaeに感染したティラピアの相対的割合生存を増加させることができた。まとめると,著者らの結果は,OnGal-2が細菌負荷を減らし,組織損傷を損傷し,抗細菌免疫応答を調節することにより細菌感染から魚を保護でき,また,O.niloticus培養における潜在的ワクチンアジュバントとして応用可能であることを示す。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 炎症 ,  血清 ,  抗細菌作用 ,  脾臓 ,  *免疫反応 ,  *細菌感染 ,  連鎖球菌属 ,  *ティラピア ,  遺伝子発現 ,  in vitro実験 ,  インターロイキン10
準シソーラス用語： *Oreochromis ,  *ガレクチン ,  *ナイルティラピア ,  組織損傷 , 【Automatic Indexing@JST】

著者キーワード (5件)： ガレクチン-2 ,  Oreochromis niloticus ,  Streptococcus agalactiae ,  免疫応答 ,  ワクチンアジュバント

分類 (3件)： 生体防御と免疫系一般  (ED01010F) ,  感染免疫  (ED03030P) ,  増養殖の技術  (FH04020Y)

タイトルに関連する用語 (5件)： 細菌感染 ,  免疫応答 ,  ナイルティラピア ,  ガレクチン ,  役割