熊本浩樹

クマモトヒロキ | Kumamoto Hiroki

所属機関・部署：
職名：准教授
競争的資金等の研究課題 (2件)：

2006 - 2007 新規SAHase 阻害剤;塩基部,糖部修飾型ヌクレオシドの合成と生物活性の探索
2003 - 2004 糖部2',3'炭素置換d4ヌクレオシドの新規合成法の開発と抗HIV活性の探索

論文 (74件)：

Kazuhiro Haraguchi, Yasuaki Kimura, Hiroshi Abe, Hiroki Kumamoto, Hiromichi Tanaka. Stereoselective synthesis of novel 4′-methylsulfanyl-pyrimidine ribonucleosides by means of nucleophilic substitution of the 4′-benzoyloxy leaving group. Tetrahedron. 2025. 179. 134581-134581
Yoshiaki Yasutake, Shin-ichiro Hattori, Hiroki Kumamoto, Noriko Tamura, Kenji Maeda, Hiroaki Mitsuya. Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations. Scientific Reports. 2024. 14. 1. 15742
Kazuhiro Haraguchi, Hiroki Kumamoto, Shuhei Imoto, Nobuyo Kuwata-Higashi, Hiroaki Mitsuya. Regio- and Stereoselective Synthesis of 2′-Deoxy-4′-thioguanine Nucleosides: Evaluation of Anti-Hepatitis B Virus Activity and Cytotoxicity Leading to Improved Selectivity Index by 4′-C-Cyanation. Synlett. 2023. 35. 06. 728-733
Yuki Takamatsu, Sanae Hayashi, Hiroki Kumamoto, Shuhei Imoto, Yasuhito Tanaka, Hiroaki Mitsuya, Nobuyo Higashi-Kuwata. A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes. Virus research. 2023. 329. 199094-199094
Hiroki Kumamoto, Nobuyo Higashi-Kuwata, Sanae Hayashi, Debananda Das, Haydar Bulut, Ryoh Tokuda, Shuhei Imoto, Kengo Onitsuka, Yuka Honda, Yuki Odanaka, et al. Synthesis of novel entecavir analogues having 4′-cyano-6′′-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent. RSC Advances. 2023. 13. 23. 15999-16011

MISC (1件)：

熊本浩樹, 鍬田(東)伸好, 林佐奈衣, DAS Debananda, BULUT Haydar, 徳田亮, 井本修平, 鬼塚健吾, 本多由佳, 小田中友紀, et al. シアノ基およびフッ素原子を有する新規エンテカビル誘導体の合成と抗HBV作用の評価. 日本薬学会年会要旨集(Web). 2023. 143rd

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