研究者
J-GLOBAL ID:202101000363244002   更新日: 2024年07月26日

熊本 浩樹

クマモト ヒロキ | Kumamoto Hiroki
所属機関・部署:
職名: 准教授
競争的資金等の研究課題 (2件):
  • 2006 - 2007 新規SAHase 阻害剤;塩基部,糖部修飾型ヌクレオシドの合成と生物活性の探索
  • 2003 - 2004 糖部2',3'炭素置換d4ヌクレオシドの新規合成法の開発と抗HIV活性の探索
論文 (73件):
  • Yoshiaki Yasutake, Shin-ichiro Hattori, Hiroki Kumamoto, Noriko Tamura, Kenji Maeda, Hiroaki Mitsuya. Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations. Scientific Reports. 2024. 14. 1. 15742
  • Kazuhiro Haraguchi, Hiroki Kumamoto, Shuhei Imoto, Nobuyo Kuwata-Higashi, Hiroaki Mitsuya. Regio- and Stereoselective Synthesis of 2′-Deoxy-4′-thioguanine Nucleosides: Evaluation of Anti-Hepatitis B Virus Activity and ­Cytotoxicity Leading to Improved Selectivity Index by 4′-C-Cyanation. Synlett. 2023. 35. 06. 728-733
  • Yuki Takamatsu, Sanae Hayashi, Hiroki Kumamoto, Shuhei Imoto, Yasuhito Tanaka, Hiroaki Mitsuya, Nobuyo Higashi-Kuwata. A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes. Virus research. 2023. 329. 199094-199094
  • Hiroki Kumamoto, Nobuyo Higashi-Kuwata, Sanae Hayashi, Debananda Das, Haydar Bulut, Ryoh Tokuda, Shuhei Imoto, Kengo Onitsuka, Yuka Honda, Yuki Odanaka, et al. Synthesis of novel entecavir analogues having 4′-cyano-6′′-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent. RSC Advances. 2023. 13. 23. 15999-16011
  • Kazuhiro Haraguchi, Noyori Hannda, Mizuki Wakasugi, Madoka Maruyama, Hirokazu Ishii, Daisuke Nagano, Hiroki Kumamoto. DAST-Mediated Fluorination of 1-[4-Thio-β-d-arabinofuranosyl]uracil: Investigation of Thiolane vs Thietane Formation and Stereoselective Synthesis of 4′-ThioFAC. Synthesis. 2022. 54. 24. 5509-5519
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