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J-GLOBAL ID：202102217286306917   整理番号：21A0022298

異種プライムブースト:Tembusuウイルスに対する重要な候補免疫戦略【JST・京大機械翻訳】

Heterologous prime-boost: an important candidate immunization strategy against Tembusu virus

著者 (57件)： Pan Yuting (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Pan Yuting (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Jia Renyong (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Jia Renyong (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Jia Renyong (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Li Juping (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Li Juping (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Wang Mingshu (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Wang Mingshu (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Wang Mingshu (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Chen Shun (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Chen Shun (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Chen Shun (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Liu Mafeng (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Liu Mafeng (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Liu Mafeng (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Zhu Dekang (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Zhu Dekang (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Zhu Dekang (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Zhao Xinxin (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Zhao Xinxin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Zhao Xinxin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Wu Ying (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Wu Ying (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Wu Ying (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Yang Qiao (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Yang Qiao (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Yang Qiao (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Yin Zhongqiong (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Jing Bo (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Huang Juan (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Huang Juan (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Huang Juan (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Zhang Shaqiu (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Zhang Shaqiu (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Zhang Shaqiu (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Zhang Lin (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Zhang Lin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Zhang Lin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Liu Yunya (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Liu Yunya (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Liu Yunya (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Yu Yanlin (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Yu Yanlin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Yu Yanlin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Tian Bin (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Tian Bin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Tian Bin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Pan Leichang (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Pan Leichang (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Pan Leichang (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Rehman Mujeeb Ur (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Rehman Mujeeb Ur (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Rehman Mujeeb Ur (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China) ,  Cheng Anchun (Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Cheng Anchun (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, People’s Republic of China) ,  Cheng Anchun (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, People’s Republic of China)
資料名： Virology Journal (Web)  (Virology Journal (Web))
巻： 17  号： 1  ページ： 1-10  発行年： 2020年 
JST資料番号： U7347A  ISSN： 1743-422X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 新たに出現した病原性フラビウイルスであるTembusuウイルス(TMUV)はアヒル間で急速に広がり,中国のアヒル産業において大きな経済的損失を引き起こす。ワクチン接種はTMUVを防ぐ最も効果的な方法である。したがって,TMUVに対する効果的なワクチン戦略を探すことが急務である。ワクチンと組換えアデノウイルスワクチンによるブースティングによる異種プライムブースト処方プライミングは,実験動物モデルにおけるウイルスに対する防御のための成功戦略であることが証明されている。本研究では,弱毒化サルモネラワクチンおよびTMUVのE遺伝子を発現する組換えアデノウイルスワクチンを用いた異種および相同プライム-ブースト戦略を評価し,組換えアデノウイルスワクチンによるプライミングおよびブースティング,および組換えアデノウイルスワクチンによるプライミングを含む,TMUV感染に対するアヒルを保護した。口腔および細胞性免疫応答を検出し,評価した。次に,これらの異なる戦略の後,臨床症状,死亡率,ウイルス負荷および組織病理学的病変に対する検査のために,ブースティング後12日でTMUVでアヒルを攻撃した。相同プライムブースト戦略と比較して,異種プライムブースト処方は,TMUVに対して高レベルの中和抗体とIgG抗体を産生した。さらに,それは後期段階で相同プライムブースト戦略よりも高いレベルのIFN-γを誘発することができた。興味深いことに,異種プライムブースト戦略は初期段階で高レベルのIL-4を誘導したが,IL-4レベルは徐々に低下し,後期段階で相同プライムブースト戦略により誘導されたものより低かった。さらに,異種プライムブースト戦略は,TMUVによるチャレンジ後のこの実験において,低いウイルス力価,臨床症状および組織病理学的病変のないアヒルを効果的に保護し,一方,わずかな臨床症状および組織病理学的病変を,相同プライムブースト戦略で観察した。著者らの結果は,異種プライムブースト戦略が,相同プライムブースト戦略よりアヒルにおけるTMUV感染に対する体液性及び細胞性免疫応答の高レベルを誘導し,TMUV感染に対する良好な保護を示し,異種プライムブースト戦略がTMUVに対する新規ワクチン戦略の設計のための重要な候補であることを示唆した。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 遺伝子 ,  口腔 ,  実験動物 ,  死亡率 ,  免疫グロブリンG ,  *ワクチン ,  アヒル ,  病原性 ,  細胞性免疫 ,  予防接種 ,  インターフェロンγ ,  フラビウイルス ,  インターロイキン4 ,  中和抗体
準シソーラス用語： 弱毒化 , 【Automatic Indexing@JST】

著者キーワード (4件)： Tembusuウイルス ,  E蛋白質 ,  ワクチン ,  プライムブースト戦略

分類 (2件)： 感染免疫  (ED03030P) ,  免疫療法薬・血液製剤の基礎研究  (GW22010D)

引用文献 (47件)：

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• Vaccine.; Role of the N-linked glycans of the prM and E envelope proteins in tick-borne encephalitis virus particle secretion; A Goto, K Yoshii, M Obara; 23; 23; 2005; 3043-3052; 10.1016/j.vaccine.2004.11.068; citation_id=CR2
• Med J Armed Forces India; Discovery of fifth serotype of dengue virus (DENV-5): a new public health dilemma in dengue control; MS Mustafa, V Rasotgi, S Jain; 71; 1; 2015; 67-70; 10.1016/j.mjafi.2014.09.011; citation_id=CR3
• Jimenez de Oya N, Escribano-Romero E, Camacho MC, et al. A recombinant subviral particle-based vaccine protects magpie (Pica pica) against West Nile virus infection. Front Microbiol. 2019; 10:1133-43.
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タイトルに関連する用語 (3件)： ウイルス ,  免疫 ,  戦略