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J-GLOBAL ID：202102219232986685   整理番号：21A0201854

スカベンジャー受容体B8はカイコ,Bombyx moriにおける自然免疫を仲介することにより生存能力を改善する【JST・京大機械翻訳】

Scavenger receptor B8 improves survivability by mediating innate immunity in silkworm, Bombyx mori

著者 (40件)： Zhang Kui (State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, China) ,  Zhang Kui (Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China) ,  Zhang Kui (Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China) ,  Zhang Kui (Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400715, Chongqing, China) ,  Hu Xin (State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, China) ,  Hu Xin (Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China) ,  Hu Xin (Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China) ,  Hu Xin (Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400715, Chongqing, China) ,  Zhao Yuzu (State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, China) ,  Zhao Yuzu (Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China) ,  Zhao Yuzu (Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China) ,  Zhao Yuzu (Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400715, Chongqing, China) ,  Pan Guangzhao (State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, China) ,  Pan Guangzhao (Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China) ,  Pan Guangzhao (Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China) ,  Pan Guangzhao (Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400715, Chongqing, China) ,  Li Chongyang (State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, China) ,  Li Chongyang (Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China) ,  Li Chongyang (Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China) ,  Li Chongyang (Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400715, Chongqing, China) ,  Ji Haoyan (State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, China) ,  Ji Haoyan (Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China) ,  Ji Haoyan (Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China) ,  Ji Haoyan (Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400715, Chongqing, China) ,  Li Changhong (State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, China) ,  Li Changhong (Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China) ,  Li Changhong (Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China) ,  Li Changhong (Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400715, Chongqing, China) ,  Yang Liqun (State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, China) ,  Yang Liqun (Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China) ,  Yang Liqun (Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China) ,  Yang Liqun (Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400715, Chongqing, China) ,  Abbas Muhammad Nadeem (State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, China) ,  Abbas Muhammad Nadeem (Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China) ,  Abbas Muhammad Nadeem (Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China) ,  Abbas Muhammad Nadeem (Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400715, Chongqing, China) ,  Cui Hongjuan (State Key Laboratory of Silkworm Genome Biology, Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture, Southwest University, China) ,  Cui Hongjuan (Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China) ,  Cui Hongjuan (Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China) ,  Cui Hongjuan (Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400715, Chongqing, China)
資料名： Developmental and Comparative Immunology  (Developmental and Comparative Immunology)
巻： 116  ページ： Null  発行年： 2021年 
JST資料番号： T0151A  ISSN： 0145-305X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： Scavenger受容体クラスB(SR-B)は,先天性免疫において重要な役割を果たす細胞外膜貫通糖蛋白質である。SR-Bは脊椎動物で広く研究されているが,それらの機能は昆虫で解明されている。ここでは,カイコ,Bombyx mori(BmSCRB8と命名)からスカベンジャー受容体クラスBメンバーを同定し,特性化した。BmSCRB8は,脂肪体,腸および血球を含む各種の免疫組織/器官で広く発現している。その発現は,異なる型の細菌または病原体関連分子パターン(PAMP)によるチャレンジ後に劇的に増強された。組換えBmSCRB8蛋白質はPAMPに直接結合することにより異なる型の細菌を検出することができ,in vivoでの細菌クリアランスを著しく改善する。BmSCRB8のノックダウン後,病原性細菌クリアランスは強く損なわれ,いくつかのAMP遺伝子は大腸菌チャレンジ後にダウンレギュレートされた。さらに,BmSCRB8の枯渇後の病原性細菌処理はカイコ幼虫の生存率を著しく低下させた。まとめると,これらの結果は,BmSCRB8がパターン認識蛋白質として作用し,細菌クリアランスを増強し,in vivoでAMPの産生に寄与することにより,カイコの先天性免疫において必須の役割を果たすことを示す。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： パターン認識 ,  細菌 ,  大腸菌 ,  遺伝子 ,  クリアランス ,  血球 ,  脊椎動物 ,  糖タンパク質 ,  幼虫 ,  *カイコガ ,  生存率 ,  *スカベンジャー受容体 ,  *自然免疫
準シソーラス用語： *Bombyx ,  外膜 , 【Automatic Indexing@JST】

著者キーワード (6件)： カイコ ,  Bombyx mori ,  BmSCRB8 ,  自然免疫 ,  細菌クリアランス ,  抗菌ペプチド

分類 (2件)： 細胞膜の受容体  (EF04030C) ,  遺伝子発現  (EC02040Q)

タイトルに関連する用語 (6件)： スカベンジャー受容体 ,  カイコ ,  自然免疫 ,  仲介 ,  生存 ,  能力