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J-GLOBAL ID：202102220333130940   整理番号：21A0082121

大うつ病性障害のバイオタイプ:静止状態デフォルトモードネットワークパターンからの神経画像エビデンス【JST・京大機械翻訳】

Biotypes of major depressive disorder: Neuroimaging evidence from resting-state default mode network patterns

著者 (84件)： Liang Sugai (Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Liang Sugai (West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Deng Wei (Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Deng Wei (West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Li Xiaojing (Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Li Xiaojing (West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Greenshaw Andrew J. (Department of Psychiatry, University of Alberta, Edmonton T6G 2B7, AB, Canada) ,  Wang Qiang (Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Wang Qiang (West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Li Mingli (Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Li Mingli (West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Ma Xiaohong (Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Ma Xiaohong (West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Bai Tong-Jian (Anhui Medical University, Hefei 230032, Anhui, China) ,  Bo Qi-Jing (Beijing Anding Hospital, Capital Medical University, Beijing 100069, China) ,  Cao Jun (Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China) ,  Chen Guan-Mao (The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong, China) ,  Chen Wei (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China) ,  Cheng Chang (The Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China) ,  Cheng Yu-Qi (First Affiliated Hospital of Kunming Medical University, Kunming 650211, Yunnan, China) ,  Cui Xi-Long (The Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China) ,  Duan Jia (Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, China) ,  Fang Yi-Ru (Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China) ,  Gong Qi-Yong (Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China) ,  Gong Qi-Yong (Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu 610040, Sichuan, China) ,  Guo Wen-Bin (The Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China) ,  Hou Zheng-Hua (Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210096, Jiangsu, China) ,  Hu Lan (Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China) ,  Kuang Li (Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China) ,  Li Feng (Beijing Anding Hospital, Capital Medical University, Beijing 100069, China) ,  Li Kai-Ming (Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China) ,  Liu Yan-Song (Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215031, Jiangsu, China) ,  Liu Zhe-Ning (The Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China) ,  Long Yi-Cheng (Faculty of Psychology, Southwest University, Chongqing 400715, China) ,  Luo Qing-Hua (Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China) ,  Meng Hua-Qing (Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215031, Jiangsu, China) ,  Peng Dai-Hui (Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China) ,  Qiu Hai-Tang (Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China) ,  Qiu Jiang (Faculty of Psychology, Southwest University, Chongqing 400715, China) ,  Shen Yue-Di (Department of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School, Hangzhou 311121, Zhejiang, China) ,  Shi Yu-Shu (Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China) ,  Si Tian-Mei (National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China) ,  Wang Chuan-Yue (Beijing Anding Hospital, Capital Medical University, Beijing 100069, China) ,  Wang Fei (Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, China) ,  Wang Kai (Beijing Anding Hospital, Capital Medical University, Beijing 100069, China) ,  Wang Li (National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China) ,  Wang Xiang (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China) ,  Wang Ying (The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong, China) ,  Wu Xiao-Ping (Xi’an Central Hospital, Xi’an 710032, Shaanxi, China) ,  Wu Xin-Ran (Faculty of Psychology, Southwest University, Chongqing 400715, China) ,  Xie Chun-Ming (Department of Neurology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210096, Jiangsu, China) ,  Xie Guang-Rong (The Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China) ,  Xie Hai-Yan (Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China) ,  Xie Peng (Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China) ,  Xie Peng (Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China) ,  Xie Peng (Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China) ,  Xu Xiu-Feng (First Affiliated Hospital of Kunming Medical University, Kunming 650211, Yunnan, China) ,  Yang Hong (Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China) ,  Yang Jian (The First Affiliated Hospital of Xi’an Jiaotong University, 710049 Shaanxi, China) ,  Yu Hua (Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Yu Hua (West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Yao Jia-Shu (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China) ,  Yao Shu-Qiao (The Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China) ,  Yin Ying-Ying (Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210096, Jiangsu, China) ,  Yuan Yong-Gui (Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210096, Jiangsu, China) ,  Zang Yu-Feng (Center for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China) ,  Zang Yu-Feng (Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 311121, Zhejiang, China) ,  Zhang Ai-Xia (The First Affiliated Hospital of Xi’an Jiaotong University, 710049 Shaanxi, China) ,  Zhang Hong (Xi’an Central Hospital, Xi’an 710032, Shaanxi, China) ,  Zhang Ke-Rang (First Hospital of Shanxi Medical University, Taiyuan 030607, Shanxi, China) ,  Zhang Zhi-Jun (Department of Neurology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210096, Jiangsu, China) ,  Zhao Jing-Ping (The Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China) ,  Zhou Ru-Bai (Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China) ,  Zhou Yi-Ting (Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Zhou Yi-Ting (West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Zou Chao-Jie (First Affiliated Hospital of Kunming Medical University, Kunming 650211, Yunnan, China) ,  Zuo Xi-Nian (CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China) ,  Zuo Xi-Nian (Department of Psychology, University of Chinese Academy of Sciences, Beijing 100101, China) ,  Zuo Xi-Nian (Magnetic Resonance Imaging Research Center and Research Center for Lifespan Development of Mind and Brain (CLIMB), Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) ,  Yan Chao-Gan (CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China) ,  Yan Chao-Gan (Department of Psychology, University of Chinese Academy of Sciences, Beijing 100101, China) ,  Yan Chao-Gan (Magnetic Resonance Imaging Research Center and Research Center for Lifespan Development of Mind and Brain (CLIMB), Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) ,  Li Tao (Mental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China) ,  Li Tao (West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China)
資料名： NeuroImage: Clinical  (NeuroImage: Clinical)
巻： 28  ページ： Null  発行年： 2020年 
JST資料番号： W3179A  ISSN： 2213-1582  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： Major抑鬱障害(MDD)は,デフォルトモードネットワーク(DMN)内の異常な機能的連結性と関連する不均一な障害である。本研究は,障害の異質性に対する潜在的DMNパターンに基づくMDDサブタイプのデータ駆動同定と検証に焦点を当てた。標本は,中国のREST-メタ-MDDプロジェクトに基づいて,MDDの690人の患者と複数のサイトから登録された707人の健常対照者(HC)を含む1397人の参加者から成った。ベースライン静止状態機能的磁気共鳴イメージング(rs-fMRI)データを各参加者に対して記録した。患者およびHCの間のDMNから識別的特徴を選択した。患者サブグループをマルチサイトデータセットにおけるK平均と主成分分析によって定義し,独立単一サイトデータセットで検証した。得られたクラスタ化の統計的有意性を確認した。人口統計学的および臨床的変数を,同定された患者サブグループの間で比較した。DMNの異なる機能的連結性プロファイルを有する2つのMDDサブグループをマルチサイトデータセットで同定し,異なる検証試料で比較的安定であった。優勢な機能障害の連結性プロファイルを,上前頭皮質,腹側内側前頭前野,後帯状皮質および楔前部の間で検出したが,一方,1つのサブグループは連結性の増加(高DMN MDD)を示し,もう1つのサブグループは連結性の減少(低DMN MDD)を示した。発見データセットにおける高DMNサブグループは,抑うつ症状の年齢関連重症度を有した。患者サブグループは,同等の人口統計学的および臨床的症状変数を有した。所見は,異なる機能不全DMN連結性パターンと関係したMDDの2つの神経サブタイプの存在を示唆し,これは,鬱病の異質性に対する有用な証拠を提供し,個別化治療戦略の探索を知らせるのに有用である。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： クラスタ化 ,  *うつ病 ,  機能障害 ,  不均一性 ,  基準線 ,  連結性 ,  主成分分析 ,  個別化医療
準シソーラス用語： 人口統計学 ,  *バイオタイプ ,  REST ,  *デフォルトモードネットワーク , 【Automatic Indexing@JST】

著者キーワード (5件)： バイオタイプ ,  デフォルトモードネットワーク ,  Majorうつ病性障害 ,  静止状態fMRI ,  機械学習

分類 (4件)： 精神障害  (GR03000A) ,  精神科の基礎医学  (GR01020I) ,  中枢神経系  (EJ12030F) ,  神経の基礎医学  (GN01020W)

タイトルに関連する用語 (6件)： 大うつ病性障害 ,  タイプ ,  静止状態 ,  デフォルトモードネットワーク ,  神経画像 ,  エビデンス