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J-GLOBAL ID：202102221087878396   整理番号：21A0377746

出産時の子孫サイズに対する有機リン系難燃剤への母体曝露のトリメスター特異的効果:中国における前向きコホート研究【JST・京大機械翻訳】

Trimester-specific effects of maternal exposure to organophosphate flame retardants on offspring size at birth: A prospective cohort study in China

著者 (16件)： Luo Dan (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Luo Dan (Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, China) ,  Liu Wenyu (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Liu Wenyu (Division of Birth Cohort Study, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China) ,  Liu Wenyu (Department of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China) ,  Wu Weixiang (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Tao Yun (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Hu Liqin (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Wang Limei (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Yu Meng (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Zhou Aifen (Wuhan Maternal and Child Healthcare Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Covaci Adrian (Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium) ,  Xia Wei (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Xu Shunqing (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Li Yuanyuan (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) ,  Mei Surong (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China)
資料名： Journal of Hazardous Materials  (Journal of Hazardous Materials)
巻： 406  ページ： Null  発行年： 2021年 
JST資料番号： B0362A  ISSN： 0304-3894  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 有機リン酸塩難燃剤(OPFRs)は,消費者製品における難燃剤および可塑剤として実質的に適用されている。OPFRsの胚発生毒性が報告されているが,ヒトデータは限られており,OPFR曝露への感受性の重要な窓は,緊急に同定する必要がある。ここでは,出生前OPFR曝露と出生サイズの間の妊娠期特異的関連を初めて調査した。15のOPFR代謝産物とトリス(2-クロロエチル)ホスファートの濃度を,中国,武漢の第1,第2,および第3の三半期で採取した妊婦213人の尿サンプルで繰り返し測定し,そして,身体計測データを医療記録から検索した。多重インフォーマントモデルにおいて,第3三半期におけるビス(1,3-ジクロロ-2-プロピル)ホスファート(BDCIPP)とビス(2-ブトキシエチル)ホスファート(BBOEP)の尿中濃度,第2三半期における4-ヒドロキシフェニル-ジフェニルリン酸(4-HO-DPHP)および第1三半期におけるジフェニルリン酸(DPHP)は出生時体重と負に相関し,その間で3つの三半期にわたる曝露効果関係における有意差がBDCIPPで観察された。第3期のBBOEP濃度は,有意な曝露効果で出生長さと負に相関した。著者らの結果は,特定のOPFRsへの出生前曝露が胎児の成長を損なう可能性があり,胎児は第3の三半期においてBDCIPPとBOOEPの発生毒性に脆弱であることを示唆する。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： リン酸塩 ,  胎児 ,  代謝産物 ,  胚発生 ,  ヒト ,  可塑剤 ,  *難燃剤 ,  多重化 ,  身体測定 ,  妊娠期 ,  妊婦 ,  *前向きコホート研究 ,  出生体重 ,  尿中濃度 ,  *出産

著者キーワード (4件)： 有機リン酸エステルエステル ,  妊婦 ,  出産結果 ,  臨界窓

分類 (1件)： その他の汚染原因物質  (SB05040W)

タイトルに関連する用語 (6件)： 出産 ,  サイズ ,  リン系難燃剤 ,  母体曝露 ,  中国 ,  前向きコホート研究