文献

J-GLOBAL ID：202102221283314686   整理番号：21A0804696

欧州におけるCOVID-19パンデミックの初期段階の癌患者におけるSARS-CoV-2感染からの特徴および早期死亡率の提示【JST・京大機械翻訳】

Presenting Features and Early Mortality from SARS-CoV-2 Infection in Cancer Patients during the Initial Stage of the COVID-19 Pandemic in Europe

著者 (42件)： Pinato David J. (Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London W12 0HS, UK) ,  Lee Alvin J. X. (Department of Oncology, University College London Hospitals, London NW1 2PG, UK) ,  Biello Federica (Department of Translational Medicine, Division of Oncology, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Segui Elia (Department of Medical Oncology, Hospital Clinic, 08036 Barcelona, Spain) ,  Aguilar-Company Juan (Department of Medical Oncology, Vall d’Hebron University Hospital and Institute of Oncology (VHIO), 08035 Barcelona, Spain) ,  Aguilar-Company Juan (Department of Infectious Diseases, Vall d’Hebron University Hospital, 08035 Barcelona, Spain) ,  Carbo Anna (Department of Medical Oncology, Catalan Institute of Oncology, University Hospital Josep Trueta, 17007 Girona, Spain) ,  Bruna Riccardo (Department of Translational Medicine, Division of Haematology, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Bower Mark (Department of Oncology and National Centre for HIV Malignancy, Chelsea & Westminster Hospital, London SW109NH, UK) ,  Rizzo Gianpiero (Department of Medical Oncology Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy) ,  Benafif Sarah (Department of Oncology, University College London Hospitals, London NW1 2PG, UK) ,  Carmona Carme (Department of Medical Oncology, Catalan Institute of Oncology, University Hospital Josep Trueta, 17007 Girona, Spain) ,  Chopra Neha (Department of Oncology, University College London Hospitals, London NW1 2PG, UK) ,  Cruz Claudia Andrea (Department of Medical Oncology, Hospital Clinic, 08036 Barcelona, Spain) ,  D’Avanzo Francesca (Department of Translational Medicine, Division of Oncology, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Evans Joanne S. (Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London W12 0HS, UK) ,  Galazi Myria (Department of Oncology, University College London Hospitals, London NW1 2PG, UK) ,  Garcia-Fructuoso Isabel (Department of Medical Oncology, Catalan Institute of Oncology, University Hospital Josep Trueta, 17007 Girona, Spain) ,  Pria Alessia Dalla (Department of Oncology and National Centre for HIV Malignancy, Chelsea & Westminster Hospital, London SW109NH, UK) ,  Newsom-Davis Thomas (Department of Oncology and National Centre for HIV Malignancy, Chelsea & Westminster Hospital, London SW109NH, UK) ,  Ottaviani Diego (Department of Oncology, University College London Hospitals, London NW1 2PG, UK) ,  Patriarca Andrea (Department of Translational Medicine, Division of Haematology, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Reyes Roxana (Department of Medical Oncology, Hospital Clinic, 08036 Barcelona, Spain) ,  Sharkey Rachel (Department of Translational Medicine, Division of Haematology, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Sng Christopher C. T. (Department of Oncology, University College London Hospitals, London NW1 2PG, UK) ,  Wong Yien Ning Sophia (Department of Oncology, University College London Hospitals, London NW1 2PG, UK) ,  Ferrante Daniela (Department of Translational Medicine, Unit of Cancer Epidemiology, CPO-Piemonte, University of Piemonte Orientale, 28100 Novara, Italy) ,  Scotti Lorenza (Department of Translational Medicine, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Avanzi Gian Carlo (Department of Translational Medicine, Divisions of Internal and Emergency Medicine, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Bellan Mattia (Department of Translational Medicine, Divisions of Internal and Emergency Medicine, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Castello Luigi Mario (Department of Translational Medicine, Divisions of Internal and Emergency Medicine, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Marco-Hernandez Javier (Department of Internal Medicine, Hospital Clinic, 08035 Barcelona, Spain) ,  Molla Meritxell (Department of Radiation Oncology, Hospital Clinic, 08035 Barcelona, Spain) ,  Pirisi Mario (Department of Translational Medicine, Divisions of Internal and Emergency Medicine, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Ruiz-Camps Isabel (Department of Infectious Diseases, Vall d’Hebron University Hospital, 08035 Barcelona, Spain) ,  Sainaghi Pier Paolo (Department of Translational Medicine, Divisions of Internal and Emergency Medicine, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Gaidano Gianluca (Department of Translational Medicine, Division of Haematology, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy) ,  Brunet Joan (Department of Medical Oncology, Catalan Institute of Oncology, University Hospital Josep Trueta, 17007 Girona, Spain) ,  Tabernero Josep (Department of Medical Oncology, Vall d’Hebron University Hospital and Institute of Oncology (VHIO), 08035 Barcelona, Spain) ,  Prat Aleix (Department of Medical Oncology, Hospital Clinic, 08036 Barcelona, Spain) ,  Prat Aleix (Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, 08035 Barcelona, Spain) ,  Gennari Alessandra (Department of Translational Medicine, Division of Oncology, University of Piemonte Orientale and Maggiore della Carita’ Hospital, 28100 Novara, Italy)
資料名： Cancers (Web)  (Cancers (Web))
巻： 12  号： 7  ページ： 1841  発行年： 2020年 
JST資料番号： U7153A  ISSN： 2072-6694  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 遡及的,多施設観察OnCovid研究からヨーロッパにおけるCOVID-19の初期発生時の癌患者における転帰を述べた。英国,イタリア,およびスペインの8施設から204の癌患者を同定し,>18歳(平均=69)で,2020年2月26日から1月1日の間にCOVID-19と診断された。合計127例(62%)は男性,184例(91%)は固形悪性腫瘍の診断で,103例(51%)は非転移性疾患であった。合計161(79%)は>1共存症を有していた。合計141人(69%)の患者が>1のCOVID-19合併症を有した。合計36(19%)は,高依存性または集中治療に拡大した。合計59名(29%)が死亡し,53名(26%)が退院し,92名(45%)が院内生存者であった。死亡率は>65歳(36%対16%)の患者で高く,>2共存症(40%対18%)で,COVID-19(38%対4%,p=0.004)で>1合併症を発症した。多変量解析は,年齢>65および>2共存症を確認し,腫瘍ステージ,活性悪性腫瘍または抗癌療法に無関係に患者死亡率を予測した。欧州におけるSARS-CoV-2感染の早期発生時に,癌患者における有害疾患経過で予測される加齢と進行年齢が予測される。進行中のOnCovid研究は,COVID-19パンデミックの初期と後期段階の間の癌患者におけるリスクと結果を比較する。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 多変量解析 ,  *死亡率 ,  腫瘍 ,  イタリア共和国 ,  英国 ,  スペイン ,  男性 ,  ヨーロッパ ,  合併症
準シソーラス用語： 集中治療 ,  共存罹患 ,  生存者 ,  悪性腫瘍 ,  *癌患者 ,  癌治療 , 【Automatic Indexing@JST】

著者キーワード (7件)： COVID-19 ,  コロナウイルス ,  SARS-CoV-2 ,  癌 ,  生存 ,  転帰 ,  死亡率

分類 (4件)： 疫学  (GB03000E) ,  抗腫よう薬の臨床への応用  (GW16020L) ,  感染症・寄生虫症一般  (GD01010H) ,  腫ようの薬物療法  (GE03032C)

引用文献 (28件)：

• Chen, N.; Zhou, M.; Dong, X.; Qu, J.; Gong, F.; Han, Y.; Qiu, Y.; Wang, J.; Liu, Y.; Wei, Y.; et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet 2020, 395, 507-513.
• Lake, M.A. What we know so far: COVID-19 current clinical knowledge and research. Clin. Med. (Lond.) 2020, 20, 124-127.
• Huang, C.; Wang, Y.; Li, X.; Ren, L.; Zhao, J.; Hu, Y.; Zhang, L.; Fan, G.; Xu, J.; Gu, X.; et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020, 395, 497-506.
• Garassino, M.C.; Whisenant, J.G.; Huang, L.C.; Trama, A.; Torri, V.; Agustoni, F.; Baena, J.; Banna, G.; Berardi, R.; Bettini, A.C.; et al. COVID-19 in patients with thoracic malignancies (TERAVOLT): First results of an international, registry-based, cohort study. Lancet Oncol. 2020.
• Dai, M.; Liu, D.; Liu, M.; Zhou, F.; Li, G.; Chen, Z.; Zhang, Z.; You, H.; Wu, M.; Zheng, Q.; et al. Patients with Cancer Appear More Vulnerable to SARS-COV-2: A Multicenter Study during the COVID-19 Outbreak. Cancer Discov. 2020.

タイトルに関連する用語 (6件)： 欧州 ,  パンデミック ,  初期段階 ,  癌患者 ,  感染 ,  早期死亡率