文献

J-GLOBAL ID：202102226444064164   整理番号：21A0097662

ウイルス感染における宿主eIF2αの役割【JST・京大機械翻訳】

The role of host eIF2α in viral infection

著者 (67件)： Liu Yuanzhi (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Liu Yuanzhi (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Liu Yuanzhi (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Wang Mingshu (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Wang Mingshu (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Wang Mingshu (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Cheng Anchun (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Cheng Anchun (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Cheng Anchun (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Yang Qiao (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Yang Qiao (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Yang Qiao (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Wu Ying (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Wu Ying (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Wu Ying (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Jia Renyong (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Jia Renyong (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Jia Renyong (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Liu Mafeng (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Liu Mafeng (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Liu Mafeng (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhu Dekang (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhu Dekang (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Chen Shun (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Chen Shun (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Chen Shun (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhang Shaqiu (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhang Shaqiu (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhang Shaqiu (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhao Xin-Xin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhao Xin-Xin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhao Xin-Xin (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Huang Juan (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Huang Juan (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Huang Juan (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Mao Sai (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Mao Sai (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Mao Sai (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Ou Xumin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Ou Xumin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Ou Xumin (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Gao Qun (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Gao Qun (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Gao Qun (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Wang Yin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Xu Zhiwen (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Chen Zhengli (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhu Ling (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Luo Qihui (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Liu Yunya (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Liu Yunya (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Liu Yunya (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Yu Yanling (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Yu Yanling (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Yu Yanling (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhang Ling (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhang Ling (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Zhang Ling (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Tian Bin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Tian Bin (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Pan Leichang (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Pan Leichang (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Rehman Mujeeb Ur (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Rehman Mujeeb Ur (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Chen Xiaoyue (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Chen Xiaoyue (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu City, P.R. China) ,  Chen Xiaoyue (Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu City, P.R. China)
資料名： Virology Journal (Web)  (Virology Journal (Web))
巻： 17  号： 1  ページ： 1-15  発行年： 2020年 
JST資料番号： U7347A  ISSN： 1743-422X  資料種別： 逐次刊行物 (A)
記事区分： 文献レビュー  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： eIF2αは,そのリン酸化または脱リン酸化により蛋白質合成開始を制御する調節結節である。一般的制御非デプレッサブル-2(GCN2),蛋白質キナーゼR様小胞体キナーゼ(PERK),二本鎖RNA(dsRNA)依存性蛋白質キナーゼ(PKR)およびヘム調節阻害剤(HRI)はeIF2αリン酸化を調節する4つのキナーゼである。ウイルス感染過程において,ウイルス増殖により産生されたdsRNAまたはウイルス蛋白質は異なるeIF2αキナーゼを活性化し,eIF2αリン酸化をもたらし,それは3成分tRNAMet-GTP-eIF2複合体形成を阻害し,宿主またはウイルス蛋白質合成を阻害する。ストールされたメッセンジャーリボ核蛋白質(mRNP)複合体はウイルス感染ストレス下でウイルスRNAと転写および翻訳関連蛋白質をカプセル化し,ウイルス増殖を制限するストレス顆粒(SG)を形成する。しかしながら,多くのウイルスは,eIF2α燐酸化により生じる宿主蛋白質合成停止とSG生成のイベントでそれ自身の蛋白質を合成するため,対応する脱出機構を進化させ,ウイルスは,PERK-eIF2α経路を介し,細胞複製サイクルをブロックし,それ自身の複製に対し好ましい環境を提供する。その後,ウイルスはeIF2α-ATF4-CHOP経路を通して宿主細胞オートファジーまたはアポトーシスを誘発することができる。本レビューは,ウイルス感染におけるeIF2αの役割をまとめ,ウイルスと宿主の間の相互作用を研究するための参照を提供する。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 相互作用 ,  *ウイルス感染 ,  小胞体 ,  タンパク質 ,  タンパク質合成 ,  リン酸化 ,  タンパク質キナーゼ ,  ウイルスタンパク質 ,  複合体 ,  アポトーシス ,  オートファジー
準シソーラス用語： *eIF-2 ,  *eIF2α ,  PERK ,  キナーゼ , 【Automatic Indexing@JST】

著者キーワード (6件)： ウイルス ,  eIF2α ,  一般的翻訳阻害 ,  ストレス顆粒 ,  細胞複製サイクル ,  オートファジー/アポトーシス

分類 (1件)： 遺伝子発現  (EC02040Q)

引用文献 (166件)：

• Genes Dev; A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo; K Asano, J Clayton, A Shalev, AG Hinnebusch; 14; 19; 2000; 2534-2546; citation_id=CR1
• Biochemistry.; Phosphorylation of Serine 51 in Initiation Factor 2α (eIF2α) Promotes Complex Formation between eIF2α(P) and eIF2B and Causes Inhibition in the Guanine Nucleotide Exchange Activity of eIF2B†; A Sudhakar, A Ramachandran, S Ghosh, EH Seyed, JK Randal, VAR Kolluru; 39; 42; 2000; 12929-12938; citation_id=CR2
• Cold Spring Harb Perspect Biol; New insights into translational regulation in the endoplasmic reticulum unfolded protein response; GD Pavitt, R David; 4; 6; 2012; 1-9; citation_id=CR3
• Biochim Biophys Acta; Cap-dependent, scanning-free translation initiation mechanisms; O Haimov, H Sinvani, R Dikstein; 1849; 11; 2015; 1313-1318; citation_id=CR4
• J Virol; Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules; M Hilda, R Margarito, CF Arias, L Susana; 82; 3; 2008; 1496; citation_id=CR5

タイトルに関連する用語 (4件)： ウイルス感染 ,  宿主 ,  eIF2α ,  役割