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J-GLOBAL ID：202102234494393518   整理番号：21A0159080

SARS-CoV-2に対するヒト肺胞2型細胞の作用性細胞病原性宿主応答【JST・京大機械翻訳】

Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2

著者 (82件)： Hekman Ryan M. (Center for Network Systems Biology, Boston University, Boston, MA, USA) ,  Hekman Ryan M. (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Hume Adam J. (Department of Microbiology, Boston University School of Medicine, Boston, MA, USA) ,  Hume Adam J. (National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA) ,  Goel Raghuveera Kumar (Center for Network Systems Biology, Boston University, Boston, MA, USA) ,  Goel Raghuveera Kumar (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Abo Kristine M. (Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA) ,  Abo Kristine M. (The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA) ,  Huang Jessie (Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA) ,  Huang Jessie (The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA) ,  Blum Benjamin C. (Center for Network Systems Biology, Boston University, Boston, MA, USA) ,  Blum Benjamin C. (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Werder Rhiannon B. (Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA) ,  Werder Rhiannon B. (The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA) ,  Suder Ellen L. (Department of Microbiology, Boston University School of Medicine, Boston, MA, USA) ,  Suder Ellen L. (National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA) ,  Paul Indranil (Center for Network Systems Biology, Boston University, Boston, MA, USA) ,  Paul Indranil (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Phanse Sadhna (Center for Network Systems Biology, Boston University, Boston, MA, USA) ,  Youssef Ahmed (Center for Network Systems Biology, Boston University, Boston, MA, USA) ,  Youssef Ahmed (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Youssef Ahmed (Bioinformatics Program, Boston University, Boston, MA, USA) ,  Alysandratos Konstantinos D. (Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA) ,  Alysandratos Konstantinos D. (The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA) ,  Padhorny Dzmitry (Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA) ,  Padhorny Dzmitry (Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, USA) ,  Ojha Sandeep (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Mora-Martin Alexandra (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Kretov Dmitry (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Ash Peter E.A. (Department of Pharmacology, Boston University School of Medicine, Boston, MA, USA) ,  Verma Mamta (Department of Pharmacology, Boston University School of Medicine, Boston, MA, USA) ,  Zhao Jian (Department of Electrical and Computer Engineering, Boston University, Boston, MA, USA) ,  Patten J.J. (Department of Microbiology, Boston University School of Medicine, Boston, MA, USA) ,  Patten J.J. (National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA) ,  Villacorta-Martin Carlos (Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA) ,  Bolzan Dante (Department of Computer Science, University of Miami, Miami, FL, USA) ,  Perea-Resa Carlos (Department of Molecular Biology, Harvard Medical School, Boston, MA, USA) ,  Bullitt Esther (Department of Physiology and Biophysics, Boston University, Boston, MA, USA) ,  Hinds Anne (The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA) ,  Tilston-Lunel Andrew (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Varelas Xaralabos (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Farhangmehr Shaghayegh (Donnelly Centre, University of Toronto, Toronto, ON, Canada) ,  Farhangmehr Shaghayegh (Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada) ,  Braunschweig Ulrich (Donnelly Centre, University of Toronto, Toronto, ON, Canada) ,  Kwan Julian H. (Center for Network Systems Biology, Boston University, Boston, MA, USA) ,  Kwan Julian H. (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  McComb Mark (Center for Network Systems Biology, Boston University, Boston, MA, USA) ,  McComb Mark (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  McComb Mark (Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, USA) ,  Basu Avik (Center for Network Systems Biology, Boston University, Boston, MA, USA) ,  Basu Avik (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Saeed Mohsan (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Saeed Mohsan (National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA) ,  Perissi Valentina (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Burks Eric J. (Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA) ,  Layne Matthew D. (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Connor John H. (Department of Microbiology, Boston University School of Medicine, Boston, MA, USA) ,  Connor John H. (National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA) ,  Davey Robert (Department of Microbiology, Boston University School of Medicine, Boston, MA, USA) ,  Davey Robert (National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA) ,  Cheng Ji-Xin (Department of Biomedical Engineering, Boston University, Boston, MA, USA) ,  Wolozin Benjamin L. (Department of Pharmacology, Boston University School of Medicine, Boston, MA, USA) ,  Blencowe Benjamin J. (Donnelly Centre, University of Toronto, Toronto, ON, Canada) ,  Blencowe Benjamin J. (Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada) ,  Wuchty Stefan (Department of Computer Science, University of Miami, Miami, FL, USA) ,  Wuchty Stefan (Department of Biology, University of Miami, Miami, FL, USA) ,  Wuchty Stefan (Miami Institute of Data Science and Computing, Miami, FL, USA) ,  Lyons Shawn M. (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Kozakov Dima (Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA) ,  Kozakov Dima (Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, USA) ,  Cifuentes Daniel (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Blower Michael (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Blower Michael (Department of Molecular Biology, Harvard Medical School, Boston, MA, USA) ,  Kotton Darrell N. (Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA) ,  Kotton Darrell N. (The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA) ,  Wilson Andrew A. (Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, USA) ,  Wilson Andrew A. (The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA) ,  Muehlberger Elke (Department of Microbiology, Boston University School of Medicine, Boston, MA, USA) ,  Muehlberger Elke (National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA) ,  Emili Andrew (Center for Network Systems Biology, Boston University, Boston, MA, USA) ,  Emili Andrew (Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA) ,  Emili Andrew (Department of Biology, Boston University, Boston, MA, USA)
資料名： Molecular Cell  (Molecular Cell)
巻： 80  号： 6  ページ： 1104-1122.e9  発行年： 2020年 
JST資料番号： W1167A  ISSN： 1097-2765  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 重症急性呼吸器症候群コロナウイルス2(SARS-CoV-2)のヒト感染,COVID-19パンデミックの原因病原体は,大きな健康と社会経済的危機を示す。ウイルスは肺胞上皮2型細胞(AT2s)に感染し,肺損傷と障害ガス交換をもたらすが,感染と病理を駆動する機序は不明である。気-液界面(ALI)でSARS-CoV-2に感染した誘導多能性幹細胞由来AT2s(iAT2s)の定量的ホスホプロテオーム調査を行った。経時変化分析は,シグナル伝達,RNAプロセシング,翻訳,代謝,核完全性,蛋白質輸送,および細胞骨格-微小管組織を含む多様な宿主系の迅速なリモデリングを明らかにし,細胞周期停止,遺伝毒性ストレス,および先天性免疫をもたらした。形質転換細胞株からの類似データとの比較は,SARS-CoV-2によって隠された呼吸特異的過程を明らかにし,著者らのiAT2ALIシステムにおける標的小分子スクリーニングにおける高いヒット率によって検証された潜在的新規治療手段を強調した。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 界面 ,  *肺胞 ,  ヒト ,  ウイルス感染症 ,  微小管 ,  *病原性 ,  病原体 ,  小分子 ,  スクリーニング ,  細胞骨格 ,  病理 ,  細胞情報伝達 ,  自然免疫
準シソーラス用語： コロナウイルス ,  *SARSウイルス ,  ホスホプロテオーム , 【Automatic Indexing@JST】

著者キーワード (10件)： 肺細胞 ,  感染症 ,  SARS-CoV-2 ,  COVID-19 ,  質量分析 ,  ホスホプロテオミクス ,  経路 ,  病因 ,  抗ウイルス薬 ,  時間経過

分類 (1件)： ウイルス感染の生理と病原性  (EG04042Y)

タイトルに関連する用語 (7件)： SARS-CoV-2 ,  ヒト ,  肺胞 ,  細胞 ,  性細胞 ,  病原性 ,  宿主応答