文献

J-GLOBAL ID：202102238384246542   整理番号：21A0099848

細菌病原体は結腸直腸癌における腫瘍抑制遺伝子の宿主結腸上皮細胞プロモーター過剰メチル化を駆動する【JST・京大機械翻訳】

Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer

著者 (33件)： Xia Xiaoxuan (Division of Biostatistics, Centre for Clinical Research and Biostatistics, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China) ,  Wu William Ka Kei (Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Wu William Ka Kei (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Wong Sunny Hei (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Wong Sunny Hei (State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Liu Dabin (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Liu Dabin (State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Kwong Thomas Ngai Yeung (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Kwong Thomas Ngai Yeung (State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Nakatsu Geicho (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Nakatsu Geicho (State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Yan Pearlly S. (Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, USA) ,  Chuang Yu-Ming (Department of Biomedical Sciences, National Chung Cheng University, Chia-Yi, Taiwan, Republic of China) ,  Chan Michael Wing-Yan (Department of Biomedical Sciences, National Chung Cheng University, Chia-Yi, Taiwan, Republic of China) ,  Coker Olabisi Oluwabukola (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Coker Olabisi Oluwabukola (State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Chen Zigui (Department of Microbiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Yeoh Yun Kit (Department of Microbiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Zhao Liuyang (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Zhao Liuyang (State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Wang Xiansong (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Wang Xiansong (State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Cheng Wing Yin (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Cheng Wing Yin (State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Chan Matthew Tak Vai (Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Chan Matthew Tak Vai (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Chan Paul Kay Sheung (Department of Microbiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Sung Joseph Jao Yiu (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Sung Joseph Jao Yiu (State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Wang Maggie Haitian (Division of Biostatistics, Centre for Clinical Research and Biostatistics, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong, Special Administrative Region of China) ,  Yu Jun (Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Yu Jun (State Key Laboratory of Digestive Diseases, Institute of Digestive Diseases, CUHK-Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China) ,  Yu Jun (Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, Special Administrative Region of China)
資料名： Microbiome (Web)  (Microbiome (Web))
巻： 8  号： 1  ページ： 1-13  発行年： 2020年 
JST資料番号： U7333A  ISSN： 2049-2618  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 腫瘍サプレッサー遺伝子(TSG)の変化したミクロビオーム組成と異常なプロモーター過メチル化は,結腸直腸癌(CRC)の2つの重要な特徴である。ここでは,33の組織生検(5つの正常結腸粘膜組織,4対の腺腫および腺腫-隣接組織,および10対のCRCおよびCRC-隣接組織)における同時16S rRNA遺伝子配列決定およびメチル-CpG結合ドメインに基づく捕獲配列決定を行い,TSGプロモーター過メチル化とCRC関連細菌の間の有意な関連を同定し,続いてメチル化関連細菌の機能的検証を行った。Fusobacterium nucleatumとHungatella hathewayiを,2つのメチル化調節細菌として同定した。bona fide TSGの標的分析は,H.hathewayとレンサ球菌属がCDX2とMLH1プロモーター過メチル化とそれぞれ有意に相関することを示した。細胞系と動物モデルによる機構的検証は,F.nucleatumとH.hathewayiがDNAメチルトランスフェラーゼをアップレギュレートすることを明らかにした。H.hathewayi接種はまた,無胚および従来のマウスにおける結腸上皮細胞増殖を促進した。著者らの統合的分析は,F.nucleatumとH.hathewayiによるDNAメチルトランスフェラーゼの誘導を通して,宿主細胞におけるTSGの以前に未知の後成的調節を明らかにし,CRC促進細菌として後者を確立した。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *細菌 ,  *メチル化 ,  *結腸 ,  腺腫 ,  結合部位 ,  *病原体 ,  DNAメチルトランスフェラーゼ ,  生検 ,  *上皮細胞 ,  大腸腫瘍 ,  *癌抑制遺伝子
準シソーラス用語： 動物モデル ,  DNAメチル化 ,  CpG ,  *結腸直腸癌 , 【Automatic Indexing@JST】

著者キーワード (5件)： 大腸癌 ,  Microbiota ,  DNAメチル化 ,  MBDCap-Seq ,  DNMT

分類 (1件)： 消化器の腫よう  (GH04000D)

引用文献 (56件)：

• CA Cancer J Clin.; Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries; F Bray, J Ferlay, I Soerjomataram, RL Siegel, LA Torre, A Jemal; 68; 6; 2018; 394-424; citation_id=CR1
• Therap Adv Gastroenterol.; Microbial dysbiosis and colon carcinogenesis: could colon cancer be considered a bacteria-related disease?; I Sobhani, A Amiot, Y Baleur, M Levy, ML Auriault, JT Nhieu, JC Delchier; 6; 3; 2013; 215-229; citation_id=CR2
• Semin Cancer Biol.; Clinical applications of gut microbiota in cancer biology; SH Wong, TNY Kwong, CY Wu, J Yu; 55; 2019; 28-36; citation_id=CR3
• Gut.; Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer; J Yu, Q Feng, SH Wong, D Zhang, QY Liang, Y Qin, L Tang, H Zhao, J Stenvang, Y Li, X Wang, X Xu, N Chen, WK Wu, J Al-Aama, HJ Nielsen, P Kiilerich, BA Jensen, Z Lan, H Jia, J Li, L Xiao, TY Lam, SC Ng, AS Cheng, VW Wong, FK Chan, X Xu, H Yang, L Madsen, C Datz, H Tilg, J Wang, N Brünner, K Kristiansen, M Arumugam, JJ Sung, J Wang; 66; 1; 2017; 70-78; citation_id=CR4
• Nat Commun.; Gut mucosal microbiome across stages of colorectal carcinogenesis; G Nakatsu, X Li, H Zhou, J Sheng, SH Wong, WK Wu, SC Ng, H Tsoi, Y Dong, N Zhang, Y He, Q Kang, L Cao, K Wang, J Zhang, Q Liang, J Yu, JJ Sung; 6; 2015; 8727; citation_id=CR5

タイトルに関連する用語 (8件)： 細菌 ,  病原体 ,  結腸直腸癌 ,  腫瘍抑制遺伝子 ,  宿主 ,  結腸 ,  上皮細胞 ,  プロモーター過剰メチル化