文献

J-GLOBAL ID：202102238992844307   整理番号：21A0201323

小児脳腫瘍のMajor組織型全体にわたる統合プロテオゲノミクス特性化【JST・京大機械翻訳】

Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer

著者 (120件)： Petralia Francesca (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Tignor Nicole (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Reva Boris (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Koptyra Mateusz (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Koptyra Mateusz (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Chowdhury Shrabanti (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Rykunov Dmitry (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Krek Azra (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Ma Weiping (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Zhu Yuankun (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Zhu Yuankun (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Ji Jiayi (Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Ji Jiayi (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Calinawan Anna (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Whiteaker Jeffrey R. (Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Colaprico Antonio (Department of Public Health Science, University of Miami Miller School of Medicine, Miami, FL 33136, USA) ,  Stathias Vasileios (Department of Pharmacology, Institute for Data Science and Computing, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33146, USA) ,  Omelchenko Tatiana (Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  Song Xiaoyu (Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Song Xiaoyu (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Raman Pichai (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Raman Pichai (Department of Bioinformatics and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Raman Pichai (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Guo Yiran (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Guo Yiran (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Brown Miguel A. (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Brown Miguel A. (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Ivey Richard G. (Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Szpyt John (Thermo Fisher Scientific Center for Multiplexed Proteomics, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA) ,  Guha Thakurta Sanjukta (Thermo Fisher Scientific Center for Multiplexed Proteomics, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA) ,  Gritsenko Marina A. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Weitz Karl K. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Lopez Gonzalo (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Kalayci Selim (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Guemues Zeynep H. (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Yoo Seungyeul (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  da Veiga Leprevost Felipe (Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA) ,  Chang Hui-Yin (Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA) ,  Krug Karsten (Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02412, USA) ,  Katsnelson Lizabeth (Institute for Systems Genetics; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA) ,  Wang Ying (Institute for Systems Genetics; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA) ,  Kennedy Jacob J. (Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Voytovich Uliana J. (Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Zhao Lei (Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Gaonkar Krutika S. (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Gaonkar Krutika S. (Department of Bioinformatics and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Gaonkar Krutika S. (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Ennis Brian M. (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Ennis Brian M. (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Zhang Bo (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Zhang Bo (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Baubet Valerie (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Baubet Valerie (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Tauhid Lamiya (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Tauhid Lamiya (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Lilly Jena V. (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Lilly Jena V. (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Mason Jennifer L. (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Mason Jennifer L. (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Farrow Bailey (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Farrow Bailey (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Young Nathan (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Young Nathan (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Leary Sarah (Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Leary Sarah (Cancer and Blood Disorders Center, Seattle Children’s Hospital, Seattle, WA 98105, USA) ,  Leary Sarah (Department of Pediatrics, University of Washington, Seattle, WA 98195, USA) ,  Moon Jamie (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Petyuk Vladislav A. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Nazarian Javad (Children’s National Research Institute, George Washington University School of Medicine, Washington, DC 20010, USA) ,  Nazarian Javad (Department of Oncology, Children’s Research Center, University Children’s Hospital Zuerich, Zuerich 8032, Switzerland) ,  Adappa Nithin D. (Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Palmer James N. (Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA 19104, USA) ,  Lober Robert M. (Department of Neurosurgery, Dayton Children’s Hospital, Dayton, OH 45404, USA) ,  Rivero-Hinojosa Samuel (Children’s National Research Institute, George Washington University School of Medicine, Washington, DC 20010, USA) ,  Wang Liang-Bo (Department of Medicine, Washington University in St. Louis, St. Louis, MO 631110, USA) ,  Wang Liang-Bo (McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA) ,  Wang Joshua M. (Institute for Systems Genetics; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA) ,  Broberg Matilda (Institute for Systems Genetics; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA) ,  Chu Rosalie K. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Moore Ronald J. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Monroe Matthew E. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Zhao Rui (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Smith Richard D. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Zhu Jun (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Robles Ana I. (Office of Cancer Clinical Proteomics Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA) ,  Mesri Mehdi (Office of Cancer Clinical Proteomics Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA) ,  Boja Emily (Office of Cancer Clinical Proteomics Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA) ,  Hiltke Tara (Office of Cancer Clinical Proteomics Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA) ,  Rodriguez Henry (Office of Cancer Clinical Proteomics Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA) ,  Zhang Bing (Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA) ,  Zhang Bing (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA) ,  Zhang Bing (Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA) ,  Schadt Eric E. (Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA) ,  Mani D.R. (Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02412, USA) ,  Ding Li (Department of Medicine, Washington University in St. Louis, St. Louis, MO 631110, USA) ,  Ding Li (McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA) ,  Ding Li (Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA) ,  Iavarone Antonio (Institute for Cancer Genetics, Department of Neurology, Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA) ,  Wiznerowicz Maciej (Poznan University of Medical Sciences, 61-701 Poznan, Poland) ,  Wiznerowicz Maciej (International Institute for Molecular Oncology, 61-203 Poznan, Poland) ,  Schuerer Stephan (Department of Pharmacology, Institute for Data Science and Computing, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33146, USA) ,  Chen Xi S. (Department of Public Health Science, University of Miami Miller School of Medicine, Miami, FL 33136, USA) ,  Chen Xi S. (Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA) ,  Heath Allison P. (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Heath Allison P. (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Rokita Jo Lynne (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Rokita Jo Lynne (Department of Bioinformatics and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Rokita Jo Lynne (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Nesvizhskii Alexey I. (Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA) ,  Nesvizhskii Alexey I. (Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA) ,  Fenyo David (Institute for Systems Genetics; Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA) ,  Rodland Karin D. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Rodland Karin D. (Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97221, USA) ,  Liu Tao (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA) ,  Gygi Steven P. (Thermo Fisher Scientific Center for Multiplexed Proteomics, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA) ,  Paulovich Amanda G. (Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Resnick Adam C. (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Resnick Adam C. (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Storm Phillip B. (Center for Data-Driven Discovery in Biomedicine, Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Storm Phillip B. (Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 183  号： 7  ページ： 1962-1985.e31  発行年： 2020年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 小児脳癌の7つの組織学的型,すなわち低悪性度神経膠腫(n=93),上衣腫(32),高悪性度神経膠腫(25),髄芽腫(22),神経節膠腫(18),頭蓋咽頭腫(16),および非定型奇形腫様腫瘍(12)にわたる218の腫瘍の全ゲノム配列決定,RNA配列決定,およびプロテオミクスとホスホプロテオミクスプロファイリングを含む包括的プロテオゲノミクス分析を報告する。プロテオミクスデータは,組織学的境界をスパンする共通の生物学的テーマを同定し,1つの組織学的タイプに使用される治療が,類似のプロテオミクス特徴を共有する他の腫瘍に効果的に適用できることを示唆する。免疫景観特性化は,診断中および診断内の多様な腫瘍微小環境を明らかにする。プロテオミクスデータは,トランスクリプトミクスデータで明らかではない体細胞変異とコピー数変動(CNV)の機能的影響をさらに明らかにする。キナーゼ-基質会合および共発現ネットワーク分析は,腫瘍形成の重要な生物学的機構を同定する。これは,基礎小児脳腫瘍生物学を明らかにし,合理的な治療選択を知らせるため,従来の組織学的境界を横切る最初の大規模プロテオゲノミクス分析である。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： RNA【核酸】 ,  *腫瘍 ,  子供 ,  神経膠腫 ,  奇形腫 ,  コピー数 ,  上衣腫 ,  髄芽腫 ,  腫瘤形成 ,  プロテオミクス
準シソーラス用語： トランスクリプトーム解析 ,  ゲノム配列 ,  共発現 ,  キナーゼ ,  *プロテオゲノミクス , 【Automatic Indexing@JST】

著者キーワード (10件)： 小児脳腫瘍 ,  プロテオミクスクラスタ ,  翻訳後修飾 ,  キナーゼ活性スコア ,  キナーゼ基質調節 ,  腫瘍微小環境 ,  BRAF変化 ,  CTNNB1突然変異 ,  再発性対原発性腫瘍 ,  CPTAC

分類 (2件)： 基礎腫よう学一般  (GE02010R) ,  神経系の腫よう  (GN04000V)

タイトルに関連する用語 (5件)： 小児脳腫瘍 ,  組織型 ,  統合 ,  プロテオゲノミクス ,  特性化