文献

J-GLOBAL ID：202102239624626514   整理番号：21A0251260

心房細動のエキソームワイド関連研究により明らかになったTks5のL396R変異の機能的役割

Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation

著者 (11件)： Yang Xiaoxi (Department of Bio-information Pharmacology, Medical Research Institute, Tokyo Medical and Dental University) ,  Yang Xiaoxi (Department of Cardiovascular Medicine, The First Hospital of China Medical University) ,  Sasano Tetsuo (Department of Biofunctional Informatics, Graduate School of Medicine, Tokyo Medical and Dental University) ,  Sasano Tetsuo (Department of Cardiovascular Medicine, Graduate School of Medicine, Tokyo Medical and Dental University) ,  Ebana Yusuke (Department of Bio-information Pharmacology, Medical Research Institute, Tokyo Medical and Dental University) ,  Ebana Yusuke (Life Science and Bioethics Research Center, Tokyo Medical and Dental Science) ,  Takeuchi Jun K. (Department of Bio-information Pharmacology, Medical Research Institute, Tokyo Medical and Dental University) ,  Ihara Kensuke (Department of Bio-information Pharmacology, Medical Research Institute, Tokyo Medical and Dental University) ,  Yamazoe Masahiro (Department of Bio-information Pharmacology, Medical Research Institute, Tokyo Medical and Dental University) ,  Yamazoe Masahiro (Department of Biofunctional Informatics, Graduate School of Medicine, Tokyo Medical and Dental University) ,  Furukawa Tetsushi (Department of Bio-information Pharmacology, Medical Research Institute, Tokyo Medical and Dental University)
資料名： Circulation Journal  (Circulation Journal)
巻： 84  号： 12  ページ： 2148-2157(J-STAGE)  発行年： 2020年 
JST資料番号： F0908A  ISSN： 1346-9843  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： 背景:心房細動(AF)は最もよく見られる心臓不整脈であるが,...

シソーラス用語： ヒト ,...
準シソーラス用語： CCR2 ,...

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著者キーワード (3件)： 炎症 ,  マクロファージ ,  ポドソーム

分類 (2件)： 循環系の基礎医学  (GJ01020K) ,  細胞生理一般  (EF02010S)

引用文献 (27件)：

• 1. Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, et al. Worldwide epidemiology of atrial fibrillation: A Global Burden of Disease 2010 Study. Circulation 2014; 129: 837-847.
• 2. Sinner MF, Tucker NR, Lunetta KL, Ozaki K, Smith JG, Trompet S, et al. Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Circulation 2014; 130: 1225-1235.
• 3. Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, Tsunoda T, et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 2002; 32: 650-654.
• 4. Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, et al. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet 2017; 49: 946-952.
• 5. Ohnishi Y, Tanaka T, Ozaki K, Yamada R, Suzuki H, Nakamura Y. A high-throughput SNP typing system for genome-wide association studies. J Hum Genet 2001; 46: 471-477.

タイトルに関連する用語 (5件)： 心房細動 ,  エキソーム ,  研究 ,  変異 ,  役割