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J-GLOBAL ID：202102242449289181   整理番号：21A0070710

肺動脈高血圧におけるトランスクリプトームプロファイルは疾患重症度と関連し,新規候補遺伝子を同定する【JST・京大機械翻訳】

Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes

著者 (31件)： Romanoski Casey E. (Department of Cellular and Molecular Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Qi Xinshuai (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Sangam Shreya (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Sangam Shreya (Department of Medicine, Indiana University, Indianapolis, IN, USA) ,  Vanderpool Rebecca R. (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Stearman Robert S. (Department of Medicine, Indiana University, Indianapolis, IN, USA) ,  Conklin Austin (Department of Cellular and Molecular Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Gonzalez-Garay Manuel (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Rischard Franz (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Ayon Ramon J. (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Wang Jian (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Wang Jian (State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, Guangzhou Medical University, Guangzhou, China) ,  Wang Jian (Department of Medicine, University of California, San Diego, La Jolla, CA, USA) ,  Simonson Tatum (Department of Medicine, University of California, San Diego, La Jolla, CA, USA) ,  Babicheva Aleksandra (Department of Medicine, University of California, San Diego, La Jolla, CA, USA) ,  Shi Yinan (Department of Medicine, Indiana University, Indianapolis, IN, USA) ,  Tang Haiyang (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Tang Haiyang (State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, Guangzhou Medical University, Guangzhou, China) ,  Makino Ayako (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Makino Ayako (Department of Medicine, University of California, San Diego, La Jolla, CA, USA) ,  Makino Ayako (Department of Physiology, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Kanthi Yogendra (Division of Intramural Research National Heart, Lung and Blood Institute Bethesda, Maryland, USA) ,  Kanthi Yogendra (Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA) ,  Geraci Mark W. (Department of Medicine, Indiana University, Indianapolis, IN, USA) ,  Garcia Joe G.N. (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Garcia Joe G.N. (Department of Physiology, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Yuan Jason X.-J. (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Yuan Jason X.-J. (Department of Medicine, University of California, San Diego, La Jolla, CA, USA) ,  Yuan Jason X.-J. (Department of Physiology, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Desai Ankit A. (Department of Medicine, College of Medicine, The University of Arizona, Tucson, AZ, USA) ,  Desai Ankit A. (Department of Medicine, Indiana University, Indianapolis, IN, USA)
資料名： Pulmonary Circulation  (Pulmonary Circulation)
巻： 10  号： 4  ページ： 2045894020968531  発行年： 2020年 
JST資料番号： W5378A  ISSN： 2045-8932  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： RNAeqを用いて,著者らは,肺高血圧症重症度の4つの指数と最も相関する61の遺伝子ベースの循環トランスクリプトミクスプロファイルを同定した。独立したデータセットにおいて,13/61(21%)遺伝子は,肺動脈高血圧症例の肺組織において対照に対して差次的に発現し,肺動脈高血圧発生に関与する可能性のある新規候補遺伝子を強調した。Copyright The Author(s) 2020 Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *遺伝子 ,  肺高血圧症 ,  *トランスクリプトーム
準シソーラス用語： *候補遺伝子 , 【Automatic Indexing@JST】

著者キーワード (4件)： 肺動脈高血圧 ,  トランスクリプトームプロファイリング ,  PBMC ,  RNAseq

分類 (3件)： 循環系の疾患  (GJ03000C) ,  循環系疾患の薬物療法  (GJ05020M) ,  循環系疾患の外科療法  (GJ05030X)

タイトルに関連する用語 (4件)： 肺動脈高血圧 ,  疾患重症度 ,  候補遺伝子 ,  同定