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J-GLOBAL ID：202102246071147536   整理番号：21A0804832

Meta分析はEμ-TCL1トランスジェニックマウスモデルにおける慢性リンパ性白血病進行の有意な性差を明らかにする【JST・京大機械翻訳】

Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Eμ-TCL1 Transgenic Mouse Model

著者 (14件)： Koch Maximilian (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Reinartz Sebastian (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Saggau Julia (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Knittel Gero (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Rosen Natascha (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Fedorchenko Oleg (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Thelen Lisa (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Barthel Romy (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Reinart Nina (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Seeger-Nukpezah Tamina (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Reinhardt Hans Christian (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Reinhardt Hans Christian (Clinic for Hematology, West German Cancer Center, University Hospital Essen, Essen, German Cancer Consortium (DKTK), 45147 Essen, Germany) ,  Hallek Michael (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany) ,  Nguyen Phuong-Hien (University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany)
資料名： Cancers (Web)  (Cancers (Web))
巻： 12  号： 7  ページ： 1980  発行年： 2020年 
JST資料番号： U7153A  ISSN： 2072-6694  資料種別： 逐次刊行物 (A)
記事区分： 短報  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： E-TCL1トランスジェニックマウスモデルは,慢性リンパ球性白血病(CLL)に対する最も広くかつ広範に使用されている動物モデルである。本報告では,300以上の個々のE-TCL1トランスジェニックマウスにおける白血病進行のメタ分析を行い,男性と比較して女性において有意に加速した疾患進行を発見した。この違いはTCL1導入遺伝子に加えてTp53の付加的欠失を伴う攻撃的CLLマウスモデルにも反映された。さらに,マウスCLL細胞の連続採用移植後,女性レシピエントは,男性レシピエントよりもCLLを早期に蓄積した。マウスモデルにおけるこの性関連不均衡は,ヒトCLL条件と著しく矛盾する。したがって,著者らの観察のために,著者らは,将来の研究におけるE-TCL1トランスジェニックコホートの実験計画と正確な記述における注意深い考察の両方を urった。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 実験計画法 ,  *性差 ,  *白血病 ,  ヒト ,  女性 ,  男性 ,  *トランスジェニックマウス ,  メタ分析
準シソーラス用語： 疾患進行 ,  *慢性リンパ性白血病 ,  動物モデル ,  導入遺伝子 ,  不均衡 ,  *マウスモデル , 【Automatic Indexing@JST】

著者キーワード (5件)： 慢性リンパ性白血病 ,  性差 ,  TCL1 ,  トランスジェニックマウスモデル ,  養子移植

分類 (1件)： 血液の腫よう  (GK04000M)

引用文献 (40件)：

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タイトルに関連する用語 (5件)： 分析 ,  トランスジェニックマウス ,  モデル ,  慢性リンパ性白血病 ,  性差