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J-GLOBAL ID：202102246215191474   整理番号：21A0160297

5歳のX連鎖Alport症候群(X-LAS)患者からの尿由来人工多能性幹細胞系の発生【JST・京大機械翻訳】

Generation of an urine-derived induced pluripotent stem cell line from a 5-year old X-linked Alport syndrome (X-LAS) patient

著者 (13件)： Guo Xiaoling (Center of Scientific Research, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China) ,  Guo Xiaoling (Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Ji Weiping (Department of General Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China) ,  Niu Chao (Center of Scientific Research, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China) ,  Niu Chao (Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Ding Yinjuan (Center of Scientific Research, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China) ,  Ding Yinjuan (Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China) ,  Chen Zhanguo (Department of Clinical Laboratory, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China) ,  Chen Congde (Center of Scientific Research, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China) ,  Tong Hongfei (Department of General Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China) ,  Han Zhao (Department of Neurology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China) ,  Chu Maoping (Center of Scientific Research, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China) ,  Chu Maoping (Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China)
資料名： Stem Cell Research (Web)  (Stem Cell Research (Web))
巻： 49  ページ： Null  発行年： 2020年 
JST資料番号： U7041A  ISSN： 1873-5061  資料種別： 逐次刊行物 (A)
記事区分： 短報  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： コラーゲンIV型α5鎖(COL4A5)の遺伝子変異は,末期腎疾患X連鎖Alport症候群(X-LAS)に遺伝性血尿症をもたらす。半接合性COL4A5遺伝子突然変異p.G1443V(c.4298G>T)を有する5歳の男性X-LAS患者の尿細胞を,OCT4,SOX2,c-MYC,およびKLF4 Yamanaka因子を含むSendaiウイルスリプログラミングキットで多能性幹細胞(iPSC)を誘発するために再プログラムした。生成したiPSC系統WMUi015-Aは,多能性マーカーを安定に発現し,正常核型(46,XY)を維持し,in vitroで3つの胚層に分化能を有した。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 遺伝 ,  突然変異 ,  分化 ,  汎用性 ,  男性 ,  核型 ,  血尿 ,  in vitro実験 ,  遺伝子変異 ,  *多能性幹細胞 ,  *iPS細胞
準シソーラス用語： *Alport症候群 ,  ESRD ,  KLF4 ,  COL4A5遺伝子 , 【Automatic Indexing@JST】

分類 (2件)： 発生と分化  (EJ16020W) ,  遺伝子発現  (EC02040Q)

タイトルに関連する用語 (5件)： Alport症候群 ,  LAS ,  患者 ,  尿 ,  人工多能性幹細胞