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J-GLOBAL ID：202102248765408788   整理番号：21A0281204

miR-429-3p/LPIN1AxisはPPARγ経路を介してニワトリ腹部脂肪沈着を促進する【JST・京大機械翻訳】

miR-429-3p/LPIN1 Axis Promotes Chicken Abdominal Fat Deposition via PPARγ Pathway

著者 (36件)： Chao Xiaohuan (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Chao Xiaohuan (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Chao Xiaohuan (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Guo Lijin (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Guo Lijin (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Guo Lijin (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Wang Qi (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Wang Qi (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Wang Qi (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Huang Weiling (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Huang Weiling (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Huang Weiling (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Liu Manqing (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Liu Manqing (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Liu Manqing (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Luan Kang (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Luan Kang (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Luan Kang (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Jiang Jinqi (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Jiang Jinqi (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Jiang Jinqi (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Lin Shudai (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Lin Shudai (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Lin Shudai (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Nie Qinghua (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Nie Qinghua (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Nie Qinghua (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Luo Wen (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Luo Wen (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Luo Wen (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Zhang Xiquan (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Zhang Xiquan (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Zhang Xiquan (College of Animal Science, South China Agricultural University, Guangzhou, China) ,  Luo Qingbin (Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, South China Agricultural University, Guangzhou, China) ,  Luo Qingbin (Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China) ,  Luo Qingbin (College of Animal Science, South China Agricultural University, Guangzhou, China)
資料名： Frontiers in Cell and Developmental Biology (Web)  (Frontiers in Cell and Developmental Biology (Web))
巻： 8  ページ： 595637  発行年： 2020年 
JST資料番号： U7062A  ISSN： 2296-634X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： ブロイラーにおける腹部脂肪沈着の調節機構を探究するために,100日齢Sanhuangニワトリ(n=12)を,腹部脂肪比サイズに従って高脂肪および低脂肪群に分けた。12の腹部脂肪組織から分離した全RNAを,miRNAとmRNA配列決定のために使用した。miRNAとmRNA配列決定の結果は,miR-429-3pが高脂肪ニワトリで高度に発現する一方,LPIN1発現は下方制御されたことを明らかにした。さらに,miR-429-3pは前脂肪細胞増殖と分化を促進するが,LPIN1は逆効果を発揮することを明らかにした。特に,miR-429-3p/LPIN1軸がPPARγ経路活性化を促進し,脂肪生成の進行と密接に関連することを見出した。結論として,著者らの結果は,新規miR-429-3p/LPIN1軸が脂肪生成の調節に関与し,ブロイラーニワトリにおける腹部脂肪形質の育種の改善において誘導的役割を持つかもしれないという証拠を提供する。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： RNA【核酸】 ,  mRNA ,  ブロイラー ,  リポゲネシス ,  ダウンレギュレーション ,  内臓脂肪 ,  *PPARγ
準シソーラス用語： マイクロRNA ,  脂肪前駆細胞 ,  *腹部脂肪 ,  トータルRNA ,  *脂肪沈着 , 【Automatic Indexing@JST】

著者キーワード (5件)： RNA-Seq ,  miR-429-3p/LPIN1軸 ,  前脂肪細胞増殖 ,  前脂肪細胞分化 ,  PPARγ経路抽象

分類 (2件)： 遺伝子発現  (EC02040Q) ,  鶏  (FD03020F)

引用文献 (47件)：

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タイトルに関連する用語 (7件)： MIR ,  PPARγ ,  経路 ,  ニワトリ ,  腹部脂肪 ,  沈着 ,  促進