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J-GLOBAL ID：202102249431963844   整理番号：21A0073784

マルチオミクスは,軽度および中等度のCOVID-19間の鋭い疾患状態シフトを解決する【JST・京大機械翻訳】

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

著者 (71件)： Su Yapeng (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Chen Daniel (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Yuan Dan (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Yuan Dan (Department of Bioengineering, University of Washington, Seattle, WA 98105, USA) ,  Lausted Christopher (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Choi Jongchan (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Dai Chengzhen L. (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Voillet Valentin (Cape Town HVTN Immunology Laboratory, Hutchinson Centre Research Institute of South Africa, NPC (HCRISA), Cape Town 8001, South Africa) ,  Voillet Valentin (Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Duvvuri Venkata R. (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Scherler Kelsey (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Troisch Pamela (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Baloni Priyanka (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Qin Guangrong (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Smith Brett (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Kornilov Sergey A. (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Rostomily Clifford (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Xu Alex (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Li Jing (Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Dong Shen (Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Rothchild Alissa (Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, WA 98109, USA) ,  Zhou Jing (Isoplexis Corporation, Branford, CT 06405, USA) ,  Murray Kim (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Edmark Rick (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Hong Sunga (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Heath John E. (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Earls John (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Zhang Rongyu (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Xie Jingyi (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Li Sarah (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Roper Ryan (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Jones Lesley (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Zhou Yong (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Rowen Lee (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Liu Rachel (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Mackay Sean (Isoplexis Corporation, Branford, CT 06405, USA) ,  O’Mahony D. Shane (Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA) ,  O’Mahony D. Shane (Providence St. Joseph Health, Renton, WA 98057, USA) ,  Dale Christopher R. (Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA) ,  Dale Christopher R. (Providence St. Joseph Health, Renton, WA 98057, USA) ,  Wallick Julie A. (Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA) ,  Wallick Julie A. (Providence St. Joseph Health, Renton, WA 98057, USA) ,  Algren Heather A. (Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA) ,  Algren Heather A. (Providence St. Joseph Health, Renton, WA 98057, USA) ,  Zager Michael A. (Center for Data Visualization, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Wei Wei (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Price Nathan D. (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Huang Sui (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Subramanian Naeha (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Subramanian Naeha (Department of Global Heath, and Department of Immunology, University of Washington, Seattle, WA 98109, USA) ,  Wang Kai (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Magis Andrew T. (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Hadlock Jenn J. (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Hood Leroy (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Hood Leroy (Providence St. Joseph Health, Renton, WA 98057, USA) ,  Aderem Alan (Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, WA 98109, USA) ,  Bluestone Jeffrey A. (Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA) ,  Lanier Lewis L. (Department of Microbiology and Immunology, University of California, San Francisco, and Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA) ,  Greenberg Philip D. (Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Greenberg Philip D. (Departments of Immunology and Medicine, University of Washington, Seattle, WA 98109, USA) ,  Gottardo Raphael (Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Gottardo Raphael (Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA) ,  Gottardo Raphael (Department of Statistics, University of Washington, Seattle, WA 98195, USA) ,  Davis Mark M. (Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Davis Mark M. (Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Davis Mark M. (The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Goldman Jason D. (Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA) ,  Goldman Jason D. (Providence St. Joseph Health, Renton, WA 98057, USA) ,  Goldman Jason D. (Division of Allergy & Infectious Diseases, University of Washington, Seattle, WA 98109, USA) ,  Heath James R. (Institute for Systems Biology, Seattle, WA 98109, USA) ,  Heath James R. (Department of Bioengineering, University of Washington, Seattle, WA 98105, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 183  号： 6  ページ： 1479-1495.e20  発行年： 2020年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 著者らは,診断後の感染の最初の週の間に採取した連続採血から,疾患重症度のすべてのレベルを示す139のCOVID-19患者の臨床測定,免疫細胞,および血漿マルチオミクスの統合分析を提示する。軽度と中等度の疾患の間の主要なシフトを同定し,その点で,炎症シグナリングの上昇は,特定のクラスの代謝物と代謝過程の消失を伴う。中程度の疾患でのこのストレスを受けた血漿環境の中で,複数の異常な免疫細胞表現型が現れ,疾患重症度の増加と共に増幅する。SARS-CoV-2に応答して異なる免疫細胞クラスがどのように協調するかを捉えるために,単一軸に120,000の免疫特徴を凝縮した。この免疫応答軸は,血液凝固の臨床計量と軽度と中等度の疾患の間の鋭い転移で,主要な血漿組成変化に独立して整列する。本研究は,中等度の疾患が治療介入のための最も効果的な設定を提供するかもしれないことを示唆する。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *血漿 ,  炎症 ,  血液凝固 ,  代謝産物 ,  表現型 ,  免疫反応
準シソーラス用語： 免疫細胞 ,  重症度 ,  *オミックス , 【Automatic Indexing@JST】

著者キーワード (10件)： 免疫応答 ,  マルチオミクス ,  COVID-19 ,  感染症 ,  プロテオミクス ,  メタボロミクス ,  単一細胞TCR-seq ,  単一細胞RNA-seq ,  CITE-seq ,  単一細胞セクレトーム

分類 (3件)： 免疫性疾患・アレルギー性疾患一般  (GD04010C) ,  細胞生理一般  (EF02010S) ,  遺伝的変異  (EC01030Y)

タイトルに関連する用語 (3件)： マルチオミクス ,  疾患 ,  シフト