文献

J-GLOBAL ID：202102250157439679   整理番号：21A0460577

ヒトおよびマウス脳におけるSARS-CoV-2の神経侵入【JST・京大機械翻訳】

Neuroinvasion of SARS-CoV-2 in human and mouse brain

著者 (60件)： Song Eric (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Zhang Ce (Department of Genetics, Yale School of Medicine, New Haven, CT) ,  Zhang Ce (Department of Neuroscience, Yale School of Medicine, New Haven, CT) ,  Israelow Benjamin (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Israelow Benjamin (Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT) ,  Lu-Culligan Alice (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Prado Alba Vieites (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Skriabine Sophie (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Lu Peiwen (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Weizman Orr-El (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Liu Feimei (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Liu Feimei (Department of Biomedical Engineering, Yale University, New Haven, CT) ,  Dai Yile (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Szigeti-Buck Klara (Department of Comparative Medicine, Yale School of Medicine, New Haven, CT) ,  Yasumoto Yuki (Department of Comparative Medicine, Yale School of Medicine, New Haven, CT) ,  Wang Guilin (Yale Center for Genome Analysis, West Haven, CT) ,  Castaldi Christopher (Yale Center for Genome Analysis, West Haven, CT) ,  Heltke Jaime (Yale Center for Genome Analysis, West Haven, CT) ,  Ng Evelyn (Yale Center for Genome Analysis, West Haven, CT) ,  Wheeler John (Yale Center for Genome Analysis, West Haven, CT) ,  Alfajaro Mia Madel (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Alfajaro Mia Madel (Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT) ,  Levavasseur Etienne (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Fontes Benjamin (Yale Environmental Health and Safety, Yale University, New Haven, CT) ,  Ravindra Neal G. (Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT) ,  Ravindra Neal G. (Department of Computer Science, Yale University, New Haven, CT) ,  Van Dijk David (Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT) ,  Van Dijk David (Department of Computer Science, Yale University, New Haven, CT) ,  Mane Shrikant (Department of Genetics, Yale School of Medicine, New Haven, CT) ,  Mane Shrikant (Yale Center for Genome Analysis, West Haven, CT) ,  Gunel Murat (Department of Genetics, Yale School of Medicine, New Haven, CT) ,  Gunel Murat (Department of Neuroscience, Yale School of Medicine, New Haven, CT) ,  Gunel Murat (Department of Neurosurgery, Yale School of Medicine, New Haven, CT) ,  Ring Aaron (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Kazmi Syed A. Jaffar (Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA) ,  Zhang Kai (Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA) ,  Wilen Craig B. (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Wilen Craig B. (Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT) ,  Horvath Tamas L. (Department of Comparative Medicine, Yale School of Medicine, New Haven, CT) ,  Plu Isabelle (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Plu Isabelle (Assistance Publique Hopitaux de Paris, Hopital Pitie-Salpetriere, Departement de Neuropathologie, Paris, France) ,  Haik Stephane (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Haik Stephane (Yale Environmental Health and Safety, Yale University, New Haven, CT) ,  Haik Stephane (Assistance Publique Hopitaux de Paris, Hopital Pitie-Salpetriere, Departement de Neuropathologie, Paris, France) ,  Haik Stephane (Assistance Publique Hopitaux de Paris, Hopital Pitie-Salpetriere, Cellule nationale de reference des maladies de Creutzfeldt-Jakob, Paris, France) ,  Thomas Jean-Leon (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Thomas Jean-Leon (Department of Neurology, Yale School of Medicine, New Haven, CT) ,  Louvi Angeliki (Department of Neuroscience, Yale School of Medicine, New Haven, CT) ,  Louvi Angeliki (Department of Neurosurgery, Yale School of Medicine, New Haven, CT) ,  Farhadian Shelli F. (Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT) ,  Farhadian Shelli F. (Department of Neurology, Yale School of Medicine, New Haven, CT) ,  Huttner Anita (Department of Pathology, Yale School of Medicine, New Haven, CT) ,  Seilhean Danielle (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Seilhean Danielle (Assistance Publique Hopitaux de Paris, Hopital Pitie-Salpetriere, Departement de Neuropathologie, Paris, France) ,  Renier Nicolas (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Bilguvar Kaya (Department of Genetics, Yale School of Medicine, New Haven, CT) ,  Bilguvar Kaya (Yale Center for Genome Analysis, West Haven, CT) ,  Iwasaki Akiko (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Iwasaki Akiko (Department of Molecular, Cellular, and Developmental Biology, Yale School of Medicine, New Haven, CT) ,  Iwasaki Akiko (Howard Hughes Medical Institute, Chevy Chase, MD)
資料名： Journal of Experimental Medicine  (Journal of Experimental Medicine)
巻： 218  号： 3  ページ： Null  発行年： 2021年 
JST資料番号： A0937B  ISSN： 0022-1007  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： COVID-19は主に呼吸器疾患と考えられているが,SARS-CoV-2は中枢神経系(CNS)を含む多臓器系に影響する。しかし,CNS感染の結果に関するコンセンサスはない。ここでは,脳に感染するSARS-CoV-2の能力を調べるために,3つの独立したアプローチを用いた。最初に,ヒト脳オルガノイドを用いて,感染および隣接ニューロンにおける代謝変化を伴う感染の明らかな証拠を観察した。しかし,I型インターフェロン応答の証拠は検出されなかった。神経感染は,ACE2を抗体で遮断するか,またはCOVID-19患者から脳脊髄液を投与することにより防止できることを証明した。第2に,ヒトACE2を過剰発現するマウスを用い,in vivoでSARS-CoV-2神経浸潤を示した。最後に,COVID-19で死亡した患者からの剖検において,皮質ニューロンにおいてSARS-CoV-2を検出し,最小免疫細胞浸潤を伴う感染と関連する病理学的特徴を記録した。これら結果は,SARS-CoV-2の神経浸潤能およびSARS-CoV-2によるニューロンの直接感染の予想外の結果の証拠を示す。Please refer to the version of record for the copyright holder. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ニューロン ,  抗体 ,  呼吸器疾患 ,  髄液 ,  中枢神経系 ,  *ヒト ,  細胞浸潤 ,  オルガノイド ,  アンギオテンシン変換酵素2 ,  過剰発現 ,  体液
準シソーラス用語： 神経浸潤 , 【Automatic Indexing@JST】

分類 (1件)： ウイルス感染の生理と病原性  (EG04042Y)

引用文献 (43件)：

• Amin. Building Models of Brain Disorders with Three-Dimensional Organoids. Neuron. 2018, 100, 389. doi:10.1016/j.neuron.2018.10.007
• Baig. Potential neuroinvasive pathways of SARS-CoV-2: Deciphering the spectrum of neurological deficit seen in coronavirus disease-2019 (COVID-19). J. Med. Virol. 2020, 92, 1845. doi:10.1002/jmv.26105
• Blanco-Melo. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Cell. 2020, 181, 1036. doi:10.1016/j.cell.2020.04.026
• Bullen. Infectability of human BrainSphere neurons suggests neurotropism of SARS-CoV-2. ALTEX. 2020, 37, 665. doi:10.14573/altex.2006111
• Cakir. Engineering of human brain organoids with a functional vascular-like system. Nat. Methods. 2019, 16, 1169. doi:10.1038/s41592-019-0586-5

タイトルに関連する用語 (6件)： ヒト ,  マウス ,  脳 ,  SARS-CoV-2 ,  神経 ,  侵入