文献

J-GLOBAL ID：202102252631420690   整理番号：21A2858715

染色体9p21遺伝子座と血管造影冠動脈疾患負荷との関連:協調的Meta分析【JST・京大機械翻訳】

Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden A Collaborative Meta-Analysis

著者 (58件)： Chan Kenneth (William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom) ,  Patel Riyaz S. (William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom) ,  Patel Riyaz S. (Department of Medicine, Cardiff University, Cardiff, United Kingdom) ,  Patel Riyaz S. (Department of Medicine, Emory University School of Medicine, Atlanta, Georgia) ,  Newcombe Paul (MRC biostatistics unit, Cambridge, United Kingdom) ,  Nelson Christopher P. (Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom) ,  Qasim Atif (Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania) ,  Epstein Stephen E. (Cardiovascular Research Institute, MedStar Health Research Institute, Washington Hospital Center, Washington DC) ,  Burnett Susan (Cardiovascular Research Institute, MedStar Health Research Institute, Washington Hospital Center, Washington DC) ,  Vaccarino Viola L. (Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia) ,  Zafari A. Maziar (Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia) ,  Shah Svati H. (Center for Human Genetics, Department of Medicine, Duke University, Durham, North Carolina) ,  Anderson Jeffrey L. (Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah) ,  Carlquist John F. (Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah) ,  Hartiala Jaana (Center for Human Genetics, Department of Medicine, Duke University, Durham, North Carolina) ,  Allayee Hooman (Center for Human Genetics, Department of Medicine, Duke University, Durham, North Carolina) ,  Hinohara Kunihiko (Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Lee Bok-Soo (Division of Cardiology, Samsung Medical Center, Sung Kyun Kwan University School of Medicine, Seoul, Korea) ,  Erl Anna (German Heart Centre Munich, Munich, Germany) ,  Ellis Katrina L. (Christchurch Cardioendocrine Research Group, Department of Medicine, University of Otago, Christchurch, New Zealand) ,  Goel Anuj (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) ,  Schaefer Arne S. (Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany) ,  El Mokhtari Nour Eddine (Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany) ,  El Mokhtari Nour Eddine (Klinik fuer Innere Medizin, Kreiskrankenhaus Rendsburg, Rendsburg, Germany) ,  Goldstein Benjamin A. (Department of Medicine, Stanford University of Medicine, Stanford, California) ,  Hlatky Mark A. (Department of Medicine, Stanford University of Medicine, Stanford, California) ,  Go Alan S. (Division of Research, Kaiser Permanente, Oakland, California) ,  Shen Gong-Qing (Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio) ,  Gong Yan (University of Florida, Health Science Center, Gainesville, Florida) ,  Pepine Carl (University of Florida, Health Science Center, Gainesville, Florida) ,  Laxton Ross C. (William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom) ,  Whittaker John C. (London School of Hygiene and Tropical Medicine, London, United Kingdom) ,  Tang W.H. Wilson (London School of Hygiene and Tropical Medicine, London, United Kingdom) ,  Johnson Julie A. (University of Florida, Health Science Center, Gainesville, Florida) ,  Wang Qing K. (Department of Molecular Cardiology, Center for Cardiovascular Genetics, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio) ,  Assimes Themistocles L. (Department of Medicine, Stanford University of Medicine, Stanford, California) ,  Nothlings Ute (The Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, Ohio; Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, and PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany) ,  Farrall Martin (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) ,  Farrall Martin (Department of Preventive Medicine, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California) ,  Farrall Martin (Department of Preventive Medicine, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California) ,  Watkins Hugh (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom) ,  Watkins Hugh (Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom) ,  Richards A. Mark (Christchurch Cardioendocrine Research Group, Department of Medicine, University of Otago, Christchurch, New Zealand) ,  Cameron Vicky A. (Christchurch Cardioendocrine Research Group, Department of Medicine, University of Otago, Christchurch, New Zealand) ,  Muendlein Axel (Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria) ,  Drexel Heinz (Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria) ,  Koch Werner (German Heart Centre Munich, Munich, Germany) ,  Park Jeong Euy (Division of Cardiology, Samsung Medical Center, Sung Kyun Kwan University School of Medicine, Seoul, Korea) ,  Kimura Akinori (Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Shen Wei-feng (Department of Cardiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China) ,  Simpson Iain A. (Wessex Regional Cardiac Unit, Southampton University Hospital, Southampton, United Kingdom) ,  Hazen Stanley L. (The Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, Ohio; Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, and PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany) ,  Horne Benjamin D. (Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah) ,  Hauser Elizabeth R. (Center for Human Genetics, Department of Medicine, Duke University, Durham, North Carolina) ,  Quyyumi Arshed A. (Department of Medicine, Emory University School of Medicine, Atlanta, Georgia) ,  Reilly Muredach P. (Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania) ,  Samani Nilesh J. (Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, United Kingdom) ,  Ye Shu (William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom)
資料名： Journal of the American College of Cardiology  (Journal of the American College of Cardiology)
巻： 61  号： 9  ページ： 957-970  発行年： 2013年 
JST資料番号： C0559C  ISSN： 0735-1097  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 本研究では,9p21遺伝子座との相関関係を確認した。1)血管造影冠状動脈疾患(CAD)負荷;2)CADの根底にある個人における心筋梗塞(MI)。染色体9p21変異体は冠状動脈性心疾患と強固に関連しているが,リスクの機構には疑問が残っており,特に遺伝子座が冠動脈アテローム負荷またはプラーク不安定性に寄与するかどうかについて疑問が残っている。CAD(臨床または血管造影)と9p21遺伝子型に沿ったMI状態の両方に関する情報を有する33,673人の被験者から成る21研究の協力を確立した。血管造影CADの存在および負荷,CADの根底にあるMI症例,およびすべての被験者の糖尿病状態に関する各コホートについて,タブリックデータを提供した。最初に,血管造影的に定義された症例と対照被験者(プールオッズ比[OR]:1.31,95%信頼区間[CI]:1.20から1.43)と9p21とCADの間の関連を確認した。血管造影CAD(n=20,987)の被験者の間で,ランダム効果モデルは,単一血管疾患(OR:1.10,95%CI:1.04~1.17)/リスク対立遺伝子のそれらと比較して,多血管CADとの関連を同定した。遺伝子型モデルは,ヘテロ接合キャリアで1.15,95%CI:1.04から1.26,ホモ接合キャリアでOR:1.23,95%CI:1.08から1.39のORを示した。最後に,両方の症例(n=17,791)と対照被験者(n=15,882)がCAD(OR:0.99,95%CI:0.95~1.03)/リスク対立遺伝子の根底にあるとき,9p21と一般的MIの間に有意な関連はなかった。9p21遺伝子座は,CADのより大きな負荷との説得力のある関連を示すが,基礎となるCADの存在下ではMIとは関連しない。これは,9p21遺伝子座が主にアテローム性動脈硬化表現型を仲介するという仮説に更なる重みを加える。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ヘテロ接合 ,  *血管 ,  遺伝子型 ,  糖尿病 ,  表現型 ,  心筋梗塞 ,  対立遺伝子 ,  プラーク ,  冠動脈硬化症 ,  *冠動脈疾患 ,  母集団 ,  ロバスト性 ,  *血管造影 ,  一塩基多型
準シソーラス用語： 被験者 , 【Automatic Indexing@JST】

著者キーワード (6件)： 9p21 ,  血管造影 ,  冠動脈疾患 ,  メタ分析 ,  心筋梗塞 ,  単一ヌクレオチド多型

分類 (3件)： 循環系の基礎医学  (GJ01020K) ,  循環系の疾患  (GJ03000C) ,  遺伝的変異  (EC01030Y)

タイトルに関連する用語 (5件)： 遺伝子座 ,  血管造影 ,  冠動脈疾患 ,  協調 ,  分析