文献

J-GLOBAL ID：202102261475867343   整理番号：21A0159967

酸化グラフェンへの血液曝露は非ヒト霊長類におけるアナフィラキシー死を引き起こす可能性がある【JST・京大機械翻訳】

Blood exposure to graphene oxide may cause anaphylactic death in non-human primates

著者 (29件)： Lin Yunfeng (State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) ,  Zhang Yu (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Zhang Yu (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Li Jiang (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Li Jiang (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Kong Huating (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Kong Huating (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Yan Qinglong (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Yan Qinglong (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Zhang Jichao (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Zhang Jichao (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Li Wei (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Li Wei (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Ren Ning (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Ren Ning (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Cui Yunzhi (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Cui Yunzhi (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Zhang Tao (State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) ,  Cai Xiaoxiao (State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) ,  Li Qian (School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 20024...) ,  Li Aiguo (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Li Aiguo (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Shi Jiye (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Shi Jiye (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Wang Lihua (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Wang Lihua (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Zhu Ying (Bioimaging Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China) ,  Zhu Ying (Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China) ,  Fan Chunhai (School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 20024...)
資料名： Nano Today  (Nano Today)
巻： 35  ページ： Null  発行年： 2020年 
JST資料番号： W3114A  ISSN： 1748-0132  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： グラフェン酸化物(GO)の毒物学的評価は,大規模工業生産と臨床翻訳の可能性の文脈の下で活発に追求されてきた。それにもかかわらず,GOの安全性は,特に高哺乳類における毒物学的プロファイルの欠如により,主に議論されている。ここでは,最大安全開始用量下のGOへの血液曝露が,非ヒト霊長類を含む哺乳類の偶発的死を引き起こすことを示した。免疫グロブリンEと重度の肺損傷の上昇レベルが死亡動物で見出され,GO誘導急性アナフィラキシー反応を示唆した。注目すべきことに,著者らは,単層カーボンナノチューブとナノダイヤモンドを含む2つの他の炭素ナノ材料のアナフィラキシー反応と死を観察しなかった。この違いは,二次元GO材料の長いin vivo循環時間から生じる可能性がある。したがって,本研究では,グラフェンおよび他のナノ材料の過敏症リスクを評価する緊急の必要性を強調した。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *アナフィラキシー ,  過敏症 ,  *死 ,  ヒト ,  *霊長類 ,  免疫グロブリンE ,  二次元 ,  毒物学 ,  工業生産 ,  単層カーボンナノチューブ ,  ナノ材料 ,  *グラフェン
準シソーラス用語： ナノダイヤモンド ,  *酸化グラフェン ,  カーボンナノ材料 , 【Automatic Indexing@JST】

著者キーワード (6件)： 酸化グラフェン(GO) ,  血液曝露 ,  非ヒト霊長類 ,  アナフィラキシー死 ,  免疫グロブリンE ,  重症肺損傷

分類 (1件)： 炭素とその化合物  (YB02060D)

タイトルに関連する用語 (6件)： 酸化グラフェン ,  血液曝露 ,  ヒト ,  霊長類 ,  アナフィラキシー ,  可能性