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J-GLOBAL ID：202102261675773726   整理番号：21A2325231

走化性および血管新生成長因子間質由来因子1αのための徐放性ナノ-ゲルデリバリーシステムの開発【JST・京大機械翻訳】

Development of a Sustained Release Nano-In-Gel Delivery System for the Chemotactic and Angiogenic Growth Factor Stromal-Derived Factor 1α

著者 (27件)： O’Dwyer Joanne (Drug Delivery & Advanced Materials Team, School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  O’Dwyer Joanne (Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  O’Dwyer Joanne (Trinity Centre for Biomedical Engineering, Trinity College Dublin (TCD), Dublin 2, Ireland) ,  Cullen Megan (Drug Delivery & Advanced Materials Team, School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  Fattah Sarinj (Drug Delivery & Advanced Materials Team, School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  Fattah Sarinj (Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  Fattah Sarinj (SFI Research Centre for Medical Devices (CURAM), National University of Ireland Galway (NUIG) & Royal College of Surgeons in Ireland (RCSI), Galway and Dublin, Ireland) ,  Murphy Robert (Department of Chemistry, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  Stefanovic Smiljana (Drug Delivery & Advanced Materials Team, School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  Stefanovic Smiljana (Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  Stefanovic Smiljana (Department of Chemistry, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  Kovarova Lenka (R & D Department, Contipro, Dolni Dobrouc 401, 561 02 Dolni Dobrouc, Czech Republic) ,  Kovarova Lenka (Faculty of Chemistry, Institute of Physical Chemistry, Brno University of Technology, Purkynova 464/118, 612 00 Brno, Czech Republic) ,  Pravda Martin (R & D Department, Contipro, Dolni Dobrouc 401, 561 02 Dolni Dobrouc, Czech Republic) ,  Velebny Vladimir (R & D Department, Contipro, Dolni Dobrouc 401, 561 02 Dolni Dobrouc, Czech Republic) ,  Heise Andreas (SFI Research Centre for Medical Devices (CURAM), National University of Ireland Galway (NUIG) & Royal College of Surgeons in Ireland (RCSI), Galway and Dublin, Ireland) ,  Heise Andreas (Department of Chemistry, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  Heise Andreas (The SFI Centre for Advanced Materials and Bioengineering Research (AMBER), National University of Ireland Galway (NUIG), Royal College of Surgeons in Ireland (RCSI) & Trinity College Dublin (TCD), Dublin, Ireland) ,  Duffy Garry P. (Trinity Centre for Biomedical Engineering, Trinity College Dublin (TCD), Dublin 2, Ireland) ,  Duffy Garry P. (SFI Research Centre for Medical Devices (CURAM), National University of Ireland Galway (NUIG) & Royal College of Surgeons in Ireland (RCSI), Galway and Dublin, Ireland) ,  Duffy Garry P. (The SFI Centre for Advanced Materials and Bioengineering Research (AMBER), National University of Ireland Galway (NUIG), Royal College of Surgeons in Ireland (RCSI) & Trinity College Dublin (TCD), Dublin, Ireland) ,  Duffy Garry P. (Anatomy, School of Medicine, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway (NUIG), Galway, Ireland) ,  Cryan Sally Ann (Drug Delivery & Advanced Materials Team, School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  Cryan Sally Ann (Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland) ,  Cryan Sally Ann (Trinity Centre for Biomedical Engineering, Trinity College Dublin (TCD), Dublin 2, Ireland) ,  Cryan Sally Ann (SFI Research Centre for Medical Devices (CURAM), National University of Ireland Galway (NUIG) & Royal College of Surgeons in Ireland (RCSI), Galway and Dublin, Ireland) ,  Cryan Sally Ann (The SFI Centre for Advanced Materials and Bioengineering Research (AMBER), National University of Ireland Galway (NUIG), Royal College of Surgeons in Ireland (RCSI) & Trinity College Dublin (TCD), Dublin, Ireland)
資料名： Pharmaceutics (Web)  (Pharmaceutics (Web))
巻： 12  号： 6  ページ： 513  発行年： 2020年 
JST資料番号： U7258A  ISSN： 1999-4923  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： Stromal-Derived Factor 1(SDF)は,創傷治癒,心筋梗塞および整形外科再生アプローチを含む,広い範囲の臨床分野での応用に対し有意な可能性を持つ,血管新生,走化性蛋白質である。しかし,SDFの26分のin vivo半減期は,現在までその臨床的翻訳を制限した。本研究では,SDFの持続的局所デリバリーを促進するために,チラミン修飾ヒアルロン酸ヒドロゲル(HATA)に組み込むことができるPGASDFナノ粒子を生産するために,星状または線状ポリ(グルタミン酸)(PGA)ポリペプチドの使用を検討した。PGASDFナノ粒子製剤の物理化学的性質と生体適合性をHATAヒドロゲルへの取り込み前に広範囲に特性化した。ナノインゲルシステムから放出されるSDFの生物活性を,マトリゲル,スクラッチおよびTranswell移動アッセイで測定した。星形および線状PGAは,粒径が255305nmおよびほぼ完全なSDF錯化のSDFナノ粒子形成を促進した。Star-PGASDFは優れた生体適合性を示し,HATAゲルに取り込まれ,in vitroで35日間持続SDF放出を促進した。遊離SDFは,スクラッチアッセイでギャップ閉鎖を有意に改善し,HUVECトランスウェル移動の2.8倍増加と,未処理細胞と比較して12時間でのマトリゲルアッセイでの全細管長の1.5倍増加を生じた。全体として,生物医学応用の範囲に適応できるナノインゲルシステムからの生物活性SDFの持続的デリバリーのための新規プラットフォームシステムを提示した。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 半減期 ,  *ゲル ,  錯体生成 ,  ポリペプチド ,  *走化性 ,  タンパク質 ,  生物活性 ,  ヒドロゲル ,  整形外科 ,  生体適合性 ,  in vitro実験 ,  *血管新生 ,  創傷治癒 ,  ナノ粒子
準シソーラス用語： マトリゲル , 【Automatic Indexing@JST】

著者キーワード (7件)： 血管新生 ,  間質由来因子 ,  持続放出 ,  ナノ粒子 ,  ヒドロゲル ,  走化性 ,  蛋白質デリバリー

分類 (2件)： 生物薬剤学(基礎)  (GY01021U) ,  医用素材  (GA05040H)

引用文献 (63件)：

• Holmes, W.D.; Consler, T.G.; Dallas, W.S.; Rocque, W.J.; Willard, D.H. Solution Studies of Recombinant Human Stromal-Cell-Derived Factor-1. Protein Expr. Purif. 2001, 21, 367-377.
• Walentowicz-Sadlecka, M.; Sadlecki, P.; Bodnar, M.; Marszalek, A.; Walentowicz, P.; Sokup, A.; Wilińska-Jankowska, A.; Grabiec, M. Stromal Derived Factor-1 (SDF-1) and Its Receptors CXCR4 and CXCR7 in Endometrial Cancer Patients. PLoS ONE 2014, 9, e84629.
• Ho, T.K.; Shiwen, X.; Abraham, D.; Tsui, J.; Baker, D. Stromal-Cell-Derived Factor-1 (SDF-1)/CXCL12 as Potential Target of Therapeutic Angiogenesis in Critical Leg Ischaemia. Cardiol. Res. Pract. 2012, 2012, 143209. Available online: http://www.ncbi.nlm.nih.gov/pubmed/22462026 (accessed on 9 June 2019).
• Liu, X.; Duan, B.; Cheng, Z.; Jia, X.; Mao, L.; Fu, H.; Che, Y.; Ou, L.; Liu, L.; Kong, D. SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion. Protein Cell 2011, 2, 845-854.
• Song, M.; Jang, H.; Lee, J.; Kim, J.H.; Kim, S.H.; Sun, K.; Park, Y. Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP. Biomaterials 2014, 35, 2436-2445.

タイトルに関連する用語 (9件)： 走化性 ,  血管新生 ,  成長因子 ,  間質 ,  因子 ,  徐放性 ,  ゲル ,  デリバリーシステム ,  開発