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J-GLOBAL ID：202102262279566664   整理番号：21A0099573

神経発達障害の危険因子としての先進父親年齢:トランスレーショナル研究【JST・京大機械翻訳】

Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study

著者 (45件)： Krug Axel (Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany) ,  Krug Axel (Center for Mind, Brain and Behavior, Marburg, Germany) ,  Krug Axel (Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany) ,  Wohr Markus (Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University Marburg, Marburg, Germany) ,  Wohr Markus (Center for Mind, Brain and Behavior, Marburg, Germany) ,  Wohr Markus (Laboratory for Behavioral Neuroscience, Department of Biology, Faculty of Science, University of Southern Denmark, Odense, Denmark) ,  Seffer Dominik (Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University Marburg, Marburg, Germany) ,  Rippberger Henrike (Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University Marburg, Marburg, Germany) ,  Sungur A. OEzge (Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University Marburg, Marburg, Germany) ,  Sungur A. OEzge (Center for Mind, Brain and Behavior, Marburg, Germany) ,  Dietsche Bruno (Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany) ,  Stein Frederike (Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany) ,  Sivalingam Sugirthan (Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany) ,  Forstner Andreas J. (Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany) ,  Forstner Andreas J. (Centre for Human Genetics, University of Marburg, Marburg, Germany) ,  Forstner Andreas J. (Department of Psychiatry (UPK), University of Basel, Basel, Switzerland) ,  Forstner Andreas J. (Department of Biomedicine, University of Basel, Basel, Switzerland) ,  Forstner Andreas J. (Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland) ,  Witt Stephanie H. (Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany) ,  Dukal Helene (Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany) ,  Streit Fabian (Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany) ,  Maaser Anna (Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany) ,  Heilmann-Heimbach Stefanie (Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany) ,  Andlauer Till F. M. (Max Planck Institute of Psychiatry, Munich, Germany) ,  Andlauer Till F. M. (Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany) ,  Andlauer Till F. M. (Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany) ,  Herms Stefan (Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany) ,  Herms Stefan (Centre for Human Genetics, University of Marburg, Marburg, Germany) ,  Herms Stefan (Department of Biomedicine, University of Basel, Basel, Switzerland) ,  Herms Stefan (Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland) ,  Hoffmann Per (Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany) ,  Hoffmann Per (Centre for Human Genetics, University of Marburg, Marburg, Germany) ,  Hoffmann Per (Department of Biomedicine, University of Basel, Basel, Switzerland) ,  Hoffmann Per (Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland) ,  Rietschel Marcella (Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany) ,  Nothen Markus M. (Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany) ,  Nothen Markus M. (Centre for Human Genetics, University of Marburg, Marburg, Germany) ,  Lackinger Martin (Biochemisch-Pharmakologisches Centrum, Institut fuer Physiologische Chemie, Philipps-University Marburg, Marburg, Germany) ,  Schratt Gerhard (Biochemisch-Pharmakologisches Centrum, Institut fuer Physiologische Chemie, Philipps-University Marburg, Marburg, Germany) ,  Schratt Gerhard (Lab of Systems Neuroscience, Department of Health Science and Technology, Institute for Neuroscience, Swiss Federal Institute of Technology, Zurich, Switzerland) ,  Koch Michael (Department of Neuropharmacology, Brain Research Institute, Centre for Cognitive Sciences, University of Bremen, Bremen, Germany) ,  Schwarting Rainer K. W. (Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University Marburg, Marburg, Germany) ,  Schwarting Rainer K. W. (Center for Mind, Brain and Behavior, Marburg, Germany) ,  Kircher Tilo (Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany) ,  Kircher Tilo (Center for Mind, Brain and Behavior, Marburg, Germany)
資料名： Molecular Autism (Web)  (Molecular Autism (Web))
巻： 11  号： 1  ページ： 1-19  発行年： 2020年 
JST資料番号： U7526A  ISSN： 2040-2392  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 進行性父親年齢(APA)は自閉症と統合失調症を含むいくつかの神経発達障害の危険因子である。このリスクを与える潜在的メカニズムはほとんど理解されていない。ここでは,健康な被験者(N=677)において,人格形質schizotypyと神経症が父親年齢と相関することを示した。年齢は,右前頭前と右内側側頭皮質における灰白質容積(VBM,N=342)とさらに正に関連した。これら2つの領域を接続する線維路(DTI,N=222)の完全性は父親年齢と正相関した。ヒトにおけるゲノムワイドメチル化分析はAPA個体において異なるメチル化を示し,APAをエピジェネティック機構に結びつけた。対応する表現型を著者らのラットモデルで得た。APAラットは,社会的コミュニケーション欠損を示し,対照と比較し,より少ない社会的超音波発声を示した。さらに,それらは,初期発達中のより高い不安とともに,行動の反復および立体型パターンを示した。神経生物学的レベルで,マイクロRNAmiR-132とmiR-134は,APAに依存してラットとヒトで異なって調節される。本研究は,APAと種間の社会的行動の間の関連を示す。それらは,神経可塑性を調節するマイクロRNAおよび/または後成的変化の発現の変化により駆動され,社会的相互作用に関与するネットワークである脳形態学的変化および前頭海馬連結性をもたらす。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ネットワーク ,  神経症 ,  メチル化 ,  統合失調症 ,  ヒト ,  表現型 ,  ラット ,  海馬 ,  側頭葉 ,  自閉症 ,  *危険因子 ,  *父親 ,  エピジェネティクス ,  神経可塑性
準シソーラス用語： *神経発達障害 , 【Automatic Indexing@JST】

著者キーワード (5件)： 高度父親年齢(APA) ,  拡散張力イメージング(DTI) ,  ボクセルベースの形態計測(VBM) ,  社会行動 ,  超音波発声

分類 (1件)： 遺伝的変異  (EC01030Y)

引用文献 (111件)：

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タイトルに関連する用語 (5件)： 神経発達障害 ,  危険因子 ,  父親 ,  年齢 ,  トランスレーショナル研究