文献

J-GLOBAL ID：202102262605900772   整理番号：21A1903434

リポ多糖外側コアトランスフェラーゼ遺伝子pcgDとhptEはアヒルにおけるPasteurella multocidaの病原性に異なって寄与する【JST・京大機械翻訳】

The lipopolysaccharide outer core transferase genes pcgD and hptE contribute differently to the virulence of Pasteurella multocida in ducks

著者 (48件)： Zhao Xinxin (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Zhao Xinxin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Zhao Xinxin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Shen Hui (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Liang Sheng (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Zhu Dekang (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Zhu Dekang (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Zhu Dekang (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Wang Mingshu (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Wang Mingshu (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Wang Mingshu (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Jia Renyong (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Jia Renyong (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Jia Renyong (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Chen Shun (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Chen Shun (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Chen Shun (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Liu Mafeng (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Liu Mafeng (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Liu Mafeng (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Yang Qiao (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Yang Qiao (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Yang Qiao (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Wu Ying (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Wu Ying (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Wu Ying (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Zhang Shaqiu (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Zhang Shaqiu (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Zhang Shaqiu (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Huang Juan (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Huang Juan (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Huang Juan (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Ou Xumin (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Ou Xumin (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Ou Xumin (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Mao Sai (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Mao Sai (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Mao Sai (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Gao Qun (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Gao Qun (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Gao Qun (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Zhang Ling (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Liu Yunya (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Yu Yanling (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Pan Leichang (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Cheng Anchun (Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China) ,  Cheng Anchun (Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, China) ,  Cheng Anchun (Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China)
資料名： Veterinary Research (Web)  (Veterinary Research (Web))
巻： 52  号： 1  ページ： 1-13  発行年： 2021年 
JST資料番号： U7558A  ISSN： 1297-9716  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： Pasteurella multocidaに起因するFowlコレラは,家禽産業に大きな経済的負担を及ぼす。リポ多糖類(LPS)はニワトリにおけるP.multocida遺伝子型L1株の増殖に必須であり,完全長LPS構造に対する特異的切断は細菌毒性を減弱できる。ここでは,アヒル血清に対する細菌耐性,外膜透過性およびアヒルにおける病原性における外部コアトランスフェラーゼ遺伝子pcgDおよびhptEの役割をさらに分析した。2つのP.multocida変異体ΔpcgDとΔhptEを構築し,銀染色により,それらがすべて切断LPSプロファイルを生成することを確認した。pcgDまたはhptEの不活性化はアヒル血清および外膜透過性に対する細菌感受性に影響しなかったが,アヒルにおける毒性をある程度減少させた。高用量接種の後,ΔpcgDは血液と脾臓で顕著に低下したコロニー形成レベルを示したが,肺と肝臓ではそうではなく,野生型株と比較して脾臓と肝臓で損傷を減少させた。対照的に,ΔhptE負荷は血液中でのみ減少し,ΔhptE感染は脾臓病変を減少させたが,重度の肝病変を誘導した。さらに,野生型株と比較して,ΔpcgDは経口または筋肉内チャレンジで有意に減少したが,ΔhptEは経口感染でのみ毒性低下を示した。したがって,pcgD欠失はアヒルにおいてより大きな病原性減衰を引き起こし,P.multocida感染定着および生存におけるpcgDの重要な役割を示した。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 細菌 ,  *遺伝子 ,  遺伝子型 ,  感受性 ,  血清 ,  コレラ ,  脾臓 ,  *リポ多糖類 ,  *アヒル ,  家禽 ,  *病原性 ,  *Pasteurella ,  野生型 ,  脾臓疾患
準シソーラス用語： コロニー形成 , 【Automatic Indexing@JST】

著者キーワード (6件)： Pasteurella multocida ,  LPS ,  外核 ,  pcgD ,  hptE ,  病原性

分類 (5件)： 微生物生理一般  (EG03051L) ,  酵素一般  (EB09010D) ,  糖質・糖鎖一般  (EB06010I) ,  微生物の生化学  (EG03020N) ,  微生物感染の生理と病原性  (EG03053T)

引用文献 (43件)：

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タイトルに関連する用語 (7件)： リポ多糖 ,  コア ,  トランスフェラーゼ ,  遺伝子 ,  アヒル ,  Pasteurella ,  病原性