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J-GLOBAL ID：202102264207107828   整理番号：21A3170346

飲用水殺菌副産物と卵巣予備量への曝露の尿中バイオマーカー:中国における横断的研究【JST・京大機械翻訳】

Urinary biomarkers of exposure to drinking water disinfection byproducts and ovarian reserve: A cross-sectional study in China

著者 (26件)： Deng Yan-Ling (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Deng Yan-Ling (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Luo Qiong (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Luo Qiong (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Liu Chong (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Liu Chong (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Zeng Jia-Yue (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Zeng Jia-Yue (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Lu Ting-Ting (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Lu Ting-Ting (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Shi Tian (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Shi Tian (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Cui Fei-Peng (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Cui Fei-Peng (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Yuan Xiao-Qiong (Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095, Jiefang Avenue, Wuhan, Hubei, PR China) ,  Miao Yu (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Miao Yu (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Zhang Min (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Zhang Min (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Chen Pan-Pan (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Chen Pan-Pan (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Li Yu-Feng (Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095, Jiefang Avenue, Wuhan, Hubei, PR China) ,  Lu Wen-Qing (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Lu Wen-Qing (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Zeng Qiang (Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China) ,  Zeng Qiang (Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China)
資料名： Journal of Hazardous Materials  (Journal of Hazardous Materials)
巻： 421  ページ： Null  発行年： 2022年 
JST資料番号： B0362A  ISSN： 0304-3894  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 実験的研究は,殺菌副産物(DBPs)が胞状卵胞成長の阻害とステロイド産生の破壊を含む卵巣毒性を引き起こすことができるが,ヒトの証拠が不足していることを示している。飲料水DBPsへの曝露の尿バイオマーカーが卵巣貯蔵と関連するかどうかを検討した。本研究は,2018年12月から2020年1月までの中国,武漢の不妊クリニックに通院する956人の女性を含んだ。卵胞数(AFC),卵巣容積(OV),抗Mullerianホルモン(AMH),卵胞刺激ホルモン(FSH)を卵巣予備能の指標として測定した。尿中ジクロロ酢酸(DCAA)とトリクロロ酢酸(TCAA)を飲料水DBP曝露の潜在的バイオマーカーとして評価した。多変量線形およびPoisson回帰モデルを適用して,尿DCAAおよびTCAA濃度の卵巣予備指標との関連を推定した。尿中DCAAとTCAAレベルの上昇は,総AFCの減少(-5.98%;95%CI:-10.30%,DCAAで-1.44%,および-12.98%;95%CI:-17.00%,TCAAで-1.70%)で,右AFCで,前者は右AFCでのみ観察されたが,左AFCでは観察されず,後者は右AFCと左AFCで推定された。さらに,尿中TCAAレベル上昇はAMH低下と単調に関連していた(-14.09%;95%CI:-24.79%,-186%)。これらの負の関係は,連続変数としてモデル化された曝露バイオマーカーに対してまだ観察された。本知見は,飲料水DBPへの曝露が卵巣予備能の減少と関連することを示唆する。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ヒト ,  ホルモン ,  *卵巣 ,  卵胞 ,  女性 ,  *飲用水 ,  FSH【ホルモン】 ,  回帰モデル ,  ステロイド産生 ,  *バイオマーカー ,  脂肪族塩素化合物 ,  脂肪族カルボン酸
準シソーラス用語： *消毒副生成物 ,  胞状卵胞 ,  卵巣予備能 ,  連続変数 , 【Automatic Indexing@JST】

著者キーワード (5件)： 殺菌副産物 ,  ジクロロ酢酸 ,  トリクロロ酢酸 ,  卵巣予備能 ,  女性の生殖健康

分類 (2件)： その他の汚染原因物質  (SB05040W) ,  用水の化学的処理  (SC02040E)

物質索引 (1件)： トリクロロ酢酸

タイトルに関連する用語 (7件)： 飲用水 ,  殺菌副産物 ,  卵巣 ,  曝露 ,  尿中バイオマーカー ,  中国 ,  研究