文献

J-GLOBAL ID：202102266418389463   整理番号：21A0829738

マウス肺発達の中期および初期偽腺段階間の線維芽細胞増殖因子受容体2bシグナリングによって誘発される重複および異なる生物活性および転写標的の証拠【JST・京大機械翻訳】

Evidence for Overlapping and Distinct Biological Activities and Transcriptional Targets Triggered by Fibroblast Growth Factor Receptor 2b Signaling between Mid- and Early Pseudoglandular Stages of Mouse Lung Development

著者 (19件)： Jones Matthew R. (Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China) ,  Jones Matthew R. (Cardio-Pulmonary Institute, Institute of Lung Health and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giesse...) ,  Lingampally Arun (Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China) ,  Lingampally Arun (Cardio-Pulmonary Institute, Institute of Lung Health and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giesse...) ,  Wu Jin (International Collaborative Center on Growth Factor Research, Life Science Institute, Wenzhou University, Wenzhou 325035, China) ,  Sedighi Jamschid (Cardio-Pulmonary Institute, Institute of Lung Health and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giesse...) ,  Ahmadvand Negah (Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China) ,  Ahmadvand Negah (Cardio-Pulmonary Institute, Institute of Lung Health and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giesse...) ,  Wilhelm Jochen (Cardio-Pulmonary Institute, Institute of Lung Health and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giesse...) ,  Vazquez-Armendariz Ana Ivonne (Cardio-Pulmonary Institute, Institute of Lung Health and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giesse...) ,  Herold Susanne (Cardio-Pulmonary Institute, Institute of Lung Health and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giesse...) ,  Chen Chengshui (Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China) ,  Zhang Jin-San (Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China) ,  Zhang Jin-San (International Collaborative Center on Growth Factor Research, Life Science Institute, Wenzhou University, Wenzhou 325035, China) ,  Bellusci Saverio (Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China) ,  Bellusci Saverio (Cardio-Pulmonary Institute, Institute of Lung Health and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giesse...) ,  Chao Cho-Ming (Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China) ,  Chao Cho-Ming (Cardio-Pulmonary Institute, Institute of Lung Health and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, 35392 Giesse...) ,  Chao Cho-Ming (Division of General Pediatrics and Neonatology, University Children’s Hospital Giessen,Justus-Liebig-University, 35392 Giessen, Germany)
資料名： Cells (Web)  (Cells (Web))
巻： 9  号： 5  ページ： 1274  発行年： 2020年 
JST資料番号： U7155A  ISSN： 2073-4409  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 分岐形態形成は,Rument木から分岐する過程を受ける肺のような器官に共通する基本的な発達様式である。しかし,分岐器官の形成の基礎となる正確な分子および細胞塩基はまだ不明である。初期発生時の線維芽細胞成長因子受容体2b(Fgfr2b)シグナル伝達の不活性化は,肺非発生を導くため,後期発生段階でこの経路の分析を防ぎ,トランスジェニックマウスを用いて,肺発生の中期偽腺段階に対応する胚日(E)14.5でFgfr2bリガンドを不活性化するFgfr2bの可溶性型の発現を誘導した。上皮に富む46の遺伝子から成るFgfr2bシグナル伝達シグネチャを同定したが,その幾つかは,E12.5で以前に同定されたFgfr2bシグナル伝達シグネチャとは異なっていた。結果は,E14.5でのFgfr2bシグナリングが,主に増殖と肺胞2型細胞(AT2)分化を制御することを示す。加えて,E14.5でのFgfr2bシグナリングの阻害は,欠損した肺胞系統形成を伴い,E18.5で形態学的および細胞障害を生じる。さらなる研究は,肺発生の連続的段階(頭蓋/嚢/肺胞)でのFgfr2bシグナル伝達の役割と,損傷後のホメオスタシスと再生および修復の間,解明されなければならない。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 遺伝子 ,  上皮 ,  *線維芽細胞 ,  肺胞 ,  分化 ,  ホメオスタシス ,  形態形成 ,  *生物活性 ,  トランスジェニックマウス ,  細胞情報伝達 ,  モルフォロジー
準シソーラス用語： リガンド ,  細胞障害 ,  初期胚発生 ,  頭蓋 , 【Automatic Indexing@JST】

著者キーワード (4件)： 肺の発達 ,  Fgf ,  Fgfr2b ,  偽腺

分類 (1件)： 発生と分化  (EJ16020W)

引用文献 (25件)：

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• Warburton, D.; El-Hashash, A.; Carraro, G.; Tiozzo, C.; Sala, F.; Rogers, O.; De Langhe, S.; Kemp, P.J.; Riccardi, D.; Torday, J.; et al. Lung Organogenesis. In Current Topics in Developmental Biology; 2010; Volume 90, pp. 73-158.
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• Cardoso, W.V.; Lü, J. Regulation of early lung morphogenesis: Questions, facts and controversies. Development 2006, 133, 1611-1624.

タイトルに関連する用語 (12件)： マウス ,  肺 ,  発達 ,  中期 ,  初期 ,  段階 ,  シグナリング ,  誘発 ,  生物活性 ,  転写 ,  標的 ,  証拠