文献

J-GLOBAL ID：202102270071898145   整理番号：21A0156056

シルデナフィルはマウスにおける骨髄由来サプレッサー細胞の抑制により母体-胎児免疫耐性を損なう【JST・京大機械翻訳】

Sildenafil might impair maternal-fetal immunotolerance by suppressing myeloid-derived suppressor cells in mice

著者 (33件)： Jiang H.H. (Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Jiang H.H. (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Jiang H.H. (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Jiang H.H. (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Jiang H.H. (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Wang K.X. (Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Wang K.X. (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Wang K.X. (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Wang K.X. (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Wang K.X. (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Bi K.H. (Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Bi K.H. (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Bi K.H. (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Lu Z.M. (Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Lu Z.M. (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Lu Z.M. (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhang J.Q. (Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Zhang J.Q. (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhang J.Q. (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cheng H.R. (Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Cheng H.R. (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cheng H.R. (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhang M.Y. (Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Zhang M.Y. (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Zhang M.Y. (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Su J.J. (Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Su J.J. (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Su J.J. (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Y.X. (Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China) ,  Cao Y.X. (NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Y.X. (Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Y.X. (Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan Road, Hefei 230032, Anhui, China) ,  Cao Y.X. (Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China)
資料名： Journal of Reproductive Immunology  (Journal of Reproductive Immunology)
巻： 142  ページ： Null  発行年： 2020年 
JST資料番号： T0140A  ISSN： 0165-0378  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 免疫細胞の重要な集団としての骨髄由来サプレッサー細胞(MDSCs)は,T細胞機能を抑制し,Tヘルパー細胞(Th)1/Th2をTh2応答に分極させ,調節性T細胞(Tregs)を誘導し,従って妊娠中の免疫寛容を増強することを見出した。シルデナフィルは,移植失敗患者における貧弱な子宮内膜品質のために適用されてきた。それにもかかわらず,シルデナフィルはMDSCs依存性免疫抑制を減少できた。シルデナフィルがMDSCsを抑制することによって胚着床に影響を及ぼすかどうか。この疑問に取り組むため,マウスモデルを用いて,対照群(CG),シルデナフィル低用量群(LDG)および高用量群(HDG)からの末梢血および子宮内膜細胞における免疫細胞の量を検討した。両治療群は,CGからのそれらと比較して,マウス血液および子宮内膜から多形核(PMN)-MDSCsおよびTh2の顕著な欠損を示した。HDGからの子宮内膜におけるTregの頻度はCGよりも低かった。研究グループからの末梢と子宮におけるTh1/Th2比はCGからのそれらと比較して有意な増加を示した。関連性分析により,TregsのレベルはPMN-MDSCsのレベルと正に相関したが,Th1/Th2比は子宮におけるPMN-MDSCsの頻度と負に相関した。さらに,血液PMN-MDSCsと子宮内膜PMN-MDSCsの量の間には正の相関があった。これらの結果は,不良な子宮内膜受容性を有する患者に適用した場合,シルデナフィルの使用の賛否を慎重に知るべきであることを示唆する。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 子宮 ,  *胎児 ,  妊娠 ,  免疫トレランス ,  T細胞 ,  着床 ,  子宮内膜 ,  末梢血 ,  Th2細胞 ,  Th1細胞 ,  制御性T細胞
準シソーラス用語： Th1-Th2バランス ,  *母体 ,  免疫細胞 ,  マウスモデル , 【Automatic Indexing@JST】

著者キーワード (5件)： シルデナフィル ,  骨髄由来サプレッサー細胞 ,  調節性T細胞 ,  Th1/Th2 ,  母体胎児免疫トレランス

分類 (4件)： 腫ようの化学・生化学・病理学  (GE02030N) ,  生殖生理一般  (EJ15010E) ,  免疫反応一般  (ED03010T) ,  移植免疫  (ED03020E)

タイトルに関連する用語 (7件)： シルデナフィル ,  マウス ,  骨髄由来サプレッサー細胞 ,  母体 ,  胎児 ,  免疫 ,  耐性