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J-GLOBAL ID：202102275570197668   整理番号：21A0542820

アミロイド持続時間は前臨床認知低下とタウPETと関連する【JST・京大機械翻訳】

Amyloid duration is associated with preclinical cognitive decline and tau PET

著者 (35件)： Koscik Rebecca L. (Wisconsin Alzheimer’s Institute, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Koscik Rebecca L. (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Betthauser Tobey J. (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Betthauser Tobey J. (Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Jonaitis Erin M. (Wisconsin Alzheimer’s Institute, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Jonaitis Erin M. (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Allison Samantha L. (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Allison Samantha L. (Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Allison Samantha L. (Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin) ,  Clark Lindsay R. (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Clark Lindsay R. (Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Clark Lindsay R. (Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin) ,  Hermann Bruce P. (Wisconsin Alzheimer’s Institute, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Hermann Bruce P. (Department of Neurology, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Cody Karly A. (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Cody Karly A. (Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Engle Jonathan W. (Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin) ,  Barnhart Todd E. (Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin) ,  Stone Charles K. (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Chin Nathaniel A. (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Chin Nathaniel A. (Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Carlsson Cynthia M. (Wisconsin Alzheimer’s Institute, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Carlsson Cynthia M. (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Carlsson Cynthia M. (Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Carlsson Cynthia M. (Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin) ,  Asthana Sanjay (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Asthana Sanjay (Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Asthana Sanjay (Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin) ,  Christian Bradley T. (Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Christian Bradley T. (Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin) ,  Christian Bradley T. (Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, Wisconsin) ,  Johnson Sterling C. (Wisconsin Alzheimer’s Institute, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Johnson Sterling C. (Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Johnson Sterling C. (Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin) ,  Johnson Sterling C. (Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin)
資料名： Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring  (Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring)
巻： 12  号： 1  ページ： e12007  発行年： 2020年 
JST資料番号： W3076A  ISSN： 2352-8729  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 序論:この研究は,年齢-異質アミロイド軌跡群を同定し,アミロイド陽性の年齢と期間(慢性)を推定し,認知低下とタウ負荷と関係した慢性性を検討するため,縦アミロイド陽電子放出断層撮影(PET)造影に対する新しいアルゴリズムを適用する。方法:認知単対参加者(n=257)は,4つのアミロイドPETスキャン(Pittsburgh化合物B,PiB)を受けた。グループベースの軌跡モデリングを,アミロイド陽性の年齢と慢性性を推定するためにBayes定理と組み合わせたアミロイド軌跡群を同定し,モデルするために縦走査(n=171)の参加者に適用した。慢性,認知,臨床進行,およびタウPET(MK-6240)の間の関係を回帰モデルを用いて調べた。結果:慢性性は,年齢および2成分アミロイド状態よりアミロイド負荷におけるより不均一性を説明した。慢性は,より迅速な認知低下,異常認知のリスク増加,およびより高い嗅内タウと関連していた。DISCUSSION:アミロイドの慢性性は,認知低下と神経原線維のもつれ発達に関するユニークな情報を提供し,前臨床Alzheimer病の調査に有用である。Copyright 2021 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： アルゴリズム ,  *アミロイド ,  回帰モデル ,  不均一性 ,  継続時間 ,  神経原線維 ,  Alzheimer病 ,  PET【トモグラフィー】 ,  バイオマーカー
準シソーラス用語： *認知障害 ,  慢性化 ,  アミロイドPET ,  タウPET , 【Automatic Indexing@JST】

著者キーワード (9件)： アルツハイマー病 ,  アルツハイマー病 ,  β-アミロイド ,  バイオマーカー ,  慢性性 ,  グループベース軌道モデリング ,  ポジトロンエミッショントモグラフィー ,  タウ ,  軌道モデリング

分類 (1件)： 神経系の診断  (GN02000H)

タイトルに関連する用語 (5件)： アミロイド ,  持続時間 ,  臨床 ,  認知低下 ,  タウPET