文献

J-GLOBAL ID：202102279774027489   整理番号：21A1471008

遺伝性心臓病における予測遺伝子検査の心理社会的影響:予測研究【JST・京大機械翻訳】

Psychosocial Impact of Predictive Genetic Testing in Hereditary Heart Diseases: The PREDICT Study

著者 (51件)： Bordet Celine (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Brice Sandrine (Sorbonne Universite, INSERM, Institut Pierre Louis d’Epidemiologie et de Sante Publique, F75013 Paris, France) ,  Maupain Carole (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Maupain Carole (APHP, department of cardiology, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Maupain Carole (ACTION Study Group, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Gandjbakhch Estelle (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Gandjbakhch Estelle (APHP, department of cardiology, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Gandjbakhch Estelle (ACTION Study Group, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Gandjbakhch Estelle (Sorbonne Universite, INSERM, UMRS 1166 and ICAN Institute for Cardiometabolism and Nutrition, 75013 Paris, France) ,  Isidor Bertrand (Department of Genetics, Nantes University Hospital, 44000 Nantes, France) ,  Palmyre Aurelien (APHP, department of Genetics, Ambroise Pare University Hospital, 92100 Boulogne-Billancourt, France) ,  Moerman Alexandre (Department of Genetics, Lille University Hospital, Jeanne de Flandre Hospital, 59000 Lille, France) ,  Toutain Annick (Department of Medical Genetics, Tours University Hospital, 37044 Tours, France) ,  Akloul Linda (Department of Medical Genetics, Rennes University Hospital, 35000 Rennes, France) ,  Brehin Anne-Claire (Normandie University, UNIROUEN, Inserm U1245 and Rouen University Hospital, Department of Genetics and Reference Center for Developmental Disorders, Normandy Center for Genomic and Personalized Medicine, F 76000 Rouen, France) ,  Sawka Caroline (Medical Genetics Unit, FHU TRANSLAD and GIMI Institute, Dijon University Hospital, 21000 Dijon, France) ,  Rooryck Caroline (Department of Medical Genetics, CHU Bordeaux, Bordeaux, France, F-33000 Bordeaux, France) ,  Schaefer Elise (Department of Genetics, Strasbourg University Hospital, Institut de Genetique Medicale d’Alsace, 67200 Strasbourg, France) ,  Nguyen Karine (Department of Medical Genetics, APHM, Timone Hospital, Marseille Medical Genetics, Aix Marseille University, 13000 Marseille, France) ,  Deguine Delphine Dupin (Department of Medical Genetics, Toulouse University Hospital, 31300 Toulouse, France) ,  Rouzier Cecile (Department of Medical Genetics, Universite Cote d’Azur, CHU, Inserm, CNRS, IRCAN, 06000 Nice, France) ,  Billy Gipsy (Department of Medical Genetics, Centre Hospitalo-Universitaire Grenoble Alpes, 38700 Grenoble, France) ,  Sene Krystelle (Clinical Genetics Unit, University Hospital, Guadeloupe University Hospital, 97159 Guadalupe Island, France) ,  Denjoy Isabelle (APHP, Department of cardiology, Referral Center for hereditary heart disease, Bichat Hospital, 75018 Paris, France) ,  Leheup Bruno (Department of Medical Genetics, University Hospital, 54042 Nancy, France) ,  Planes Marc (Department of Medical Genetics, University Hospital Morvan, 29200 Brest, France) ,  Mazzella Jean-Michael (APHP, Department of Medical Genetics, Hopital Europeen Georges Pompidou, 75015 Paris, France) ,  Staraci Stephanie (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Hebert Melanie (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Boette Elsa Le (Department of Genetics, Saint Brieuc Hospital, 22000 Saint-Brieuc, France) ,  Michon Claire-Cecile (Filiere nationale de sante CARDIOGEN, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Babonneau Marie-Lise (Filiere nationale de sante CARDIOGEN, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Curjol Angelique (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Bekhechi Amine (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Mansouri Rafik (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Raji Ibticem (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Pruny Jean-Francois (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Pruny Jean-Francois (APHP, Department of cardiology, Referral Center for hereditary heart disease, Bichat Hospital, 75018 Paris, France) ,  Fressart Veronique (APHP, UF Molecular Cardiogenetics and Myogenetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Ader Flavie (APHP, UF Molecular Cardiogenetics and Myogenetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Ader Flavie (Faculte de Pharmacie Paris Descartes, Departement 3, 75006 Paris, France) ,  Richard Pascale (APHP, UF Molecular Cardiogenetics and Myogenetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Richard Pascale (Sorbonne Universite, INSERM, UMRS 1166 and ICAN Institute for Cardiometabolism and Nutrition, 75013 Paris, France) ,  Montcel Sophie Tezenas du (Sorbonne Universite, INSERM, Institut Pierre Louis d’Epidemiologie et de Sante Publique, AP-HP, Hopitaux Universitaires Pitie-Salpetriere-Charles Foix, F75013 Paris, France) ,  Gargiulo Marcela (Sorbonne Universite, INSERM, Institut Pierre Louis d’Epidemiologie et de Sante Publique, AP-HP, Hopitaux Universitaires Pitie-Salpetriere-Charles Foix, F75013 Paris, France) ,  Gargiulo Marcela (Institut of Myologie, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Charron Philippe (APHP, Referral Center for hereditary heart disease, Department of Genetics, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Charron Philippe (ACTION Study Group, Pitie-Salpetriere University Hospital, 75013 Paris, France) ,  Charron Philippe (Sorbonne Universite, INSERM, UMRS 1166 and ICAN Institute for Cardiometabolism and Nutrition, 75013 Paris, France) ,  Charron Philippe (APHP, department of Genetics, Ambroise Pare University Hospital, 92100 Boulogne-Billancourt, France) ,  Charron Philippe (Filiere nationale de sante CARDIOGEN, Pitie-Salpetriere University Hospital, 75013 Paris, France)
資料名： Journal of Clinical Medicine (Web)  (Journal of Clinical Medicine (Web))
巻： 9  号： 5  ページ： 1365  発行年： 2020年 
JST資料番号： U7214A  ISSN： 2077-0383  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： 予測遺伝子検査(PGT)は遺伝性心臓病のリスクで無症候性関連者に提供されるが,結果開示の影響はほとんど研究されていない。著者らは,前向きコホート(PCo:n=264)に3回投与し,遡及的コホート(RCo:n=253)に1回投与する517人の成人における自己報告アンケート(状態Trait Anxiety Inventoryを含む)を用いて,遺伝性心臓病におけるPGTの心理社会的影響を評価した。PGTを受ける主な動機は,疑いのある子供とその子供を除去することであった。不安のレベルは,試験前と結果(p<0.0001)の間で増加し,結果(PCo)の後,ベースラインに戻った,そして,4.4年(RCo)で適度に上昇した。うつ病の病歴または高いベースライン不安を有する被験者は,PGT結果(それぞれp=0.004およびp<0.0001)後に不安を発症しそうであった。被験者の12.4%(PCo)と18.7%(RCo)で,専門的および/または家族生活の好ましくない変化を観察した。PGTに関するレグレットはほとんど発現しなかった(0.8%RCo,2.3%PCo)。医療上の利益は主要な動機ではなく,事前/事後のコウンセリングの役割を強調する。PGTが専門家チームによって実行されたとき,陰性影響は中程度であったが,慎重な管理は,遺伝的検査結果にかかわらず,被験者の特定のカテゴリーにおいて必要であった。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *遺伝 ,  *心臓病 ,  子供 ,  うつ病 ,  アンケート ,  母集団 ,  基準線 ,  心筋症 ,  単回投与 ,  *前向きコホート研究
準シソーラス用語： *遺伝子検査 ,  被験者 , 【Automatic Indexing@JST】

著者キーワード (7件)： 遺伝性心疾患 ,  予測遺伝学的試験 ,  心理学 ,  社会 ,  心筋症 ,  不安 ,  苦痛

分類 (3件)： 精神科の臨床医学一般  (GR01030T) ,  代謝異常・栄養性疾患一般  (GD05010J) ,  臨床腫よう学一般  (GE03010Y)

引用文献 (33件)：

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タイトルに関連する用語 (7件)： 遺伝 ,  心臓病 ,  予測 ,  遺伝子検査 ,  心理 ,  社会的影響 ,  研究