文献

J-GLOBAL ID：202102282848592965   整理番号：21A0073302

メラノーマにおけるCD147蛋白質の標的分解【JST・京大機械翻訳】

Targeted degradation of CD147 proteins in melanoma

著者 (35件)： Zhou Zhe (The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Zhou Zhe (Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Zhou Zhe (Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Zhou Zhe (National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Long Jing (The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Long Jing (Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Long Jing (Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Long Jing (National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Wang Yuan (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China) ,  Li YaYun (The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Li YaYun (Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Li YaYun (Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Li YaYun (National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Zhang Xu (The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Zhang Xu (Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Zhang Xu (Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Zhang Xu (National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Tang Ling (The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Tang Ling (Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Tang Ling (Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Tang Ling (National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Chang Qi (Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China) ,  Chen Zhuo (Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China) ,  Hu GaoYun (Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China) ,  Hu Shuo (Department of Nuclear Medicine, XiangYa Hospital, Central South University, Changsha, Hunan, China) ,  Hu Shuo (Key Laboratory of Biological Nanotechnology of National Health Commission, Changsha, Hunan, China) ,  Li QianBin (Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China) ,  Peng Cong (The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Peng Cong (Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Peng Cong (Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Peng Cong (National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Chen Xiang (The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Chen Xiang (Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Chen Xiang (Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China) ,  Chen Xiang (National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China)
資料名： Bioorganic Chemistry  (Bioorganic Chemistry)
巻： 105  ページ： Null  発行年： 2020年 
JST資料番号： E0823A  ISSN： 0045-2068  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： CD147は膜貫通糖蛋白質であり,免疫グロブリンスーパーファミリーのメンバーは黒色腫細胞で強く発現する。CD147は腫瘍発生において重要な役割を持つ。したがって,それは黒色腫の有望な薬物標的である。本稿では,天然物のプソイドラリン酸B(PAB)に由来するキメラ(PROTACs)を標的化する最初のCD147蛋白質分解の発見を報告する。代表的化合物6aはCD147の分解を効果的に誘導し,in vitroおよびin vivoで黒色腫細胞を阻害した。6aは,癌ネットワークにおけるCD147の動的役割の獲得機能研究に用いられる分子生物学研究ツールキットの新規なタイプとして,または,分子生物学研究ツールキットの一部として使用することができた。Copyright 2021 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： ネットワーク ,  タンパク質 ,  糖タンパク質 ,  キメラ ,  天然材料 ,  分子生物学 ,  タンパク質分解 ,  ターゲティング ,  *黒色腫 ,  in vitro実験 ,  腫瘤形成
準シソーラス用語： ツールキット ,  免疫グロブリンスーパーファミリー ,  *CD147抗原 ,  黒色腫細胞 , 【Automatic Indexing@JST】

著者キーワード (5件)： CD147 ,  PROTAC ,  劣化 ,  プソイドラリン酸B ,  黒色腫

分類 (1件)： 酵素一般  (EB09010D)

タイトルに関連する用語 (5件)： メラノーマ ,  CD147 ,  蛋白質 ,  標的 ,  分解